Caffeine intake and the risk of incident kidney stones: a systematic review and meta-analysis

Zhao, Jiaxi; Huang, Yiqin; Yu, Xiaofeng

doi:10.1007/s11255-022-03295-1

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…Specifically, those in the highest category of caffeine intake exhibited a 32% reduction in risk (RR = 0.68; 95% CI: 0.61–0.75) compared to those with the lowest intake. This association persisted consistently across various subgroups, suggesting a protective effect of caffeine against the formation of kidney stones [ 73 ].…”

Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

“…Caffeine significantly affects the activity of the antidiuretic hormone, which leads to an increase in urine flow and a decrease in its maximum concentration. Additionally, caffeine inhibits the formation of calcium oxalate stones and reduces the adhesion of calcium oxalate crystals to the renal tubular epithelial cells’ surfaces [ 73 ]. In another study, Peerapen and Thongboonkerd provided in vitro evidence of caffeine’s protective mechanism against kidney stone formation.…”

Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

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The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

Balawender,

Łuszczki,

Mazur

et al. 2024

Nutrients

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Kidney stone disease has a multifactorial etiology, and evolving dietary habits necessitate continuous updates on the impact of dietary components on lithogenesis. The relationship between diseases influenced by lifestyle, such as obesity and diabetes, and kidney stone risk underscores the need for comprehensive lifestyle analysis. Effective management of kidney stones requires a multidisciplinary approach, involving collaboration among nutritionists, urologists, nephrologists, and other healthcare professionals to address the complex interactions between diet, lifestyle, and individual susceptibility. Personalized dietary therapy, based on each patient’s unique biochemical and dietary profile, is essential and necessitates comprehensive nutritional assessments. Accurate dietary intake evaluation is best achieved through seven-day, real-time dietary records. Key factors influencing urinary risk include fluid intake, dietary protein, carbohydrates, oxalate, calcium, and sodium chloride. Personalized interventions, such as customized dietary changes based on gut microbiota, may improve stone prevention and recurrence. Current research suggests individualized guidance on alcohol intake and indicates that tea and coffee consumption might protect against urolithiasis. There is potential evidence linking tobacco use and secondhand smoke to increased kidney stone risk. The effects of vitamins and physical activity on kidney stone risk remain unresolved due to mixed evidence. For diseases influenced by lifestyle, conclusive evidence on targeted interventions for nephrolithiasis prevention is lacking, though preliminary research suggests potential benefits. Management strategies emphasize lifestyle modifications to reduce recurrence risks, support rapid recovery, and identify predisposing conditions, highlighting the importance of these changes despite inconclusive data.

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Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

Balawender,

Łuszczki,

Mazur

et al. 2024

Nutrients

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show abstract

“…Studies showed that coffee is beneficial for some kidney-related diseases. In a systematic review and meta-analysis study, it was shown that a higher CAF intake may be associated with a lower risk of kidney stones [ 62 ]. In another systematic review and meta-analysis, it was revealed that coffee consumption may be associated with a lower risk of chronic kidney disease (CKD) [ 63 ].…”

Section: The Impact Of Coffee During Pregnancy and In Diseasesmentioning

confidence: 99%

The Epigenetic Effects of Coffee

Ding

Lau

2023

Molecules

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In this review, we discuss the recent knowledge regarding the epigenetic effects of coffee extract and the three essential active ingredients in coffee (caffeine, chlorogenic acid, and caffeic acid). As a popular beverage, coffee has many active ingredients which have a variety of biological functions such as insulin sensitization, improvement of sugar metabolism, antidiabetic properties, and liver protection. However, recent researches have shown that coffee is not only beneficial for human, but also bad, which may be due to its complex components. Studies suggest that coffee extract and its components can potentially impact gene expression via alteration of DNA methylation, histone modifications, and ncRNA expression; thus, exert long lasting impacts on the epigenome. More importantly, coffee consumption during pregnancy has been linked to multiple negative effects on offspring due to epigenetic modifications; on the other hand, it has also been linked to improvements in many diseases, including cancer. Therefore, understanding more about the epigenetic effects associated with coffee components is crucial to finding ways for improving human health.

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“…The association between coffee consumption and lower risk of CKD is also supported by other two studies [9] , [10] . In the context of kidney stone disease (nephrolithiasis), several lines of recent evidence have consistently shown the protective roles of caffeine against nephrolithiasis [11] , [12] , [13] , [14] , [15] . Although a previous study has demonstrated an acute effect of caffeine to increase urinary calcium excretion [16] , such effect is likely to be encountered by its diuretic and natriuretic activities (independent of renal tubular Na + /H + exchanger isoform 3 [17] ), resulting in lower risk of nephrolithiasis [12] .…”

Section: Introductionmentioning

confidence: 99%

Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells

Kanlaya,

Subkod,

Nanthawuttiphan

et al. 2023

Computational and Structural Biotechnology Journal

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Caffeine intake and the risk of incident kidney stones: a systematic review and meta-analysis

Cited by 6 publications

References 35 publications

The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

The Epigenetic Effects of Coffee

Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells

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