Caffeine induces neurobehavioral effects through modulating neurotransmitters

Alasmari, Fawaz

doi:10.1016/j.jsps.2020.02.005

Cited by 67 publications

(42 citation statements)

References 71 publications

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“…Thus, both in animal and human studies, changes in dopaminergic systems have been observed after caffeine exposure [ 201 ]. Different studies suggest that caffeine increases extracellular dopamine concentrations [ 202 ], as well as the expression of dopaminergic receptors [ 203 ] and transporters, which leads to an improvement of cognitive dysfunction and attention [ 204 ].…”

Section: Coffee and The Brain–gut Axismentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a complex mixture of thousands of bioactive compounds, and some of them have numerous potential health-promoting properties that have been extensively studied in the cardiovascular and central nervous systems, with relatively much less attention given to other body systems, such as the gastrointestinal tract and its particular connection with the brain, known as the brain–gut axis. This narrative review provides an overview of the effect of coffee brew; its by-products; and its components on the gastrointestinal mucosa (mainly involved in permeability, secretion, and proliferation), the neural and non-neural components of the gut wall responsible for its motor function, and the brain–gut axis. Despite in vitro, in vivo, and epidemiological studies having shown that coffee may exert multiple effects on the digestive tract, including antioxidant, anti-inflammatory, and antiproliferative effects on the mucosa, and pro-motility effects on the external muscle layers, much is still surprisingly unknown. Further studies are needed to understand the mechanisms of action of certain health-promoting properties of coffee on the gastrointestinal tract and to transfer this knowledge to the industry to develop functional foods to improve the gastrointestinal and brain–gut axis health.

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Section: Coffee and The Brain–gut Axismentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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“…Caffeine maintains a higher dopamine concentration especially in those brain areas linked with “attention.” Depending on the neurotransmitter system, caffeine can affect different brain areas with different functions (Meeusen et al, 2013 ). Usually, caffeine has delayed effect about 3–4 h of half-life (Knutti et al, 1981 , 1982 ; Nehlig, 2016 ), caffeine’s behavioral effects and the significant increase in psychomotor performance it causes have been documented in a large body of literature, in addition to improvements in attention- (Temido-Ferreira et al, 2019 ; Alasmari, 2020 ; Franceschini et al, 2020 ; Irwin et al, 2020 ; Jahrami et al, 2020 ), mood-, and vigor-based tasks (Dietz and Dekker, 2017 ; Shabir et al, 2018 ; Alasmari, 2020 ). Moreover, Beaumont et al ( 2005 ) found that the action of caffeine both shortened response times and reduced the number of errors on psychomotor tests, which indicates that caffeine has a global action on information processing and divided attention management (Beaumont et al, 2005 ; Wilhelmus et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Chen

Zhang

Yang

et al. 2020

Front. Behav. Neurosci.

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Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD. Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design. Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD. Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual's arousal level and accelerated response-related decisions, while subjects' higher-level recognition had limited improvement with prolonged awareness.

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“…Caffeine's main action mechanism is the antagonism of the A1, A2, and A3 adenosine receptors present in different areas of the CNS, including the nucleus accumbens, striatum, hypothalamus, cerebral cortex, hippocampus, olfactory bulb and tubercle (Salamone and Correa, 2012;Simoes et al 2016). This antagonism participates in inhibiting or exciting the G protein (pG) by altering phosphorylation of cyclic AMP and, as a result, modifying the flow of intracellular calcium (Kolahdouzan and Hamadeh, 2016) and the systems that modulate dopamine and glutamate release (Solinas et al 2002;Villanueva-García 2007;Villegas and Villanueva-García 2016;Lopes et al 2019;Alasmari et al 2020). The physiological effects of caffeine depend on the density of the receptors and the region of the CNS where they are found ( Figure 1).…”

Section: Pharmacodynamic Effects Of Caffeinementioning

confidence: 99%

“…This has been explained by the possible interaction of this receptor with memory and behavioral disorders. Caffeine may perform a neuroprotector function due to the increase in extracellular glutamate (Alasmari, 2020). Instilling caffeine at concentrations of 50 µM can facilitate synaptic transmission by 40% and reduce the amplitude of long-term J Anim Behav Biometeorol (2020) 8:298-307 potentializing by 35%, in association with phenomena of enhanced neuronal plasticity and the blocking of adenosine receptors (Lopes et al 2019).…”

Section: Effects In Neurodegenerative Diseasesmentioning

confidence: 99%

“…Caffeine readily crosses cell membranes, so when ingested it quickly reaches the CNS where it modifies cell processes, stimulates intellectual activity, inhibits sleep, or reduces fatigue (Fredholm et al 1999;Góngora et al 2005). Its mechanism can participate in neurobehavioral alterations by generating increased muscular activity and modulating cognition and anxiety (Hughes, 2016;Abu-Sa'da et al 2018;Alasmari, 2020). In the first two cases, therapeutic use benefits activities that entail intense physical performance or mental complexity (Southward et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Neurobehavioral and neuroprotector effects of caffeine in animal models

Villanueva-García

Mota-Rojas

Miranda-Cortés

et al. 2020

JABB

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This review aims to analyze and contrast the neurological effects associated with the use of caffeine on neurobehavior and neuroprotection in animal models. Caffeine belongs to the group of methylxanthines that exert a direct effect on adenosine receptors associated with inhibitory or excitatory G proteins, generating modification of cyclic AMP activity and intracellular calcium flow which produces alterations in the modulation system of the neurotransmitters dopamine and glutamate. The regulation of the neurotransmission systems generates protection against the inflammation of the central nervous system, by activation of the microglia and reinforcement of the blood-brain barrier. This drug will also restore cognition or prevent memory loss in Parkinson's or Alzheimer's diseases. It is important to establish new study models in other species to assess whether the behavior of the molecule is similar and to obtain other clinical applications in its behavioral and neuroprotective effects.

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Caffeine induces neurobehavioral effects through modulating neurotransmitters

Cited by 67 publications

References 71 publications

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Neurobehavioral and neuroprotector effects of caffeine in animal models

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