Caffeine increases the velocity of rapid eye movements in unfatigued humans

Connell, Charlotte; Thompson, Benjamin; Turuwhenua, Jason; Hess, Robert F.

doi:10.1007/s00213-017-4638-1

Cited by 16 publications

(14 citation statements)

References 47 publications

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“…The use of nervous system stimulants such as caffeine can have invigorating effects on humans and counter fatigue (Connell et al., 2017), which is why multiple included studies asked participants to refrain from caffeine before performing the fatigue measurement experiments. However, missing even a morning coffee by habitual caffeine drinkers can initiate withdrawal effects (Phillips‐Bute & Lane, 1997).…”

Section: Discussionmentioning

confidence: 99%

Mental fatigue measurement using eye metrics: A systematic literature review

Bafna

Hansen

2021

Psychophysiology

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Mental fatigue measurement techniques utilize one or a combination of the cognitive, affective, and behavioral responses of the body. Eye-tracking and electrooculography, which are used to compute eye-based features, have gained momentum with increases in accuracy and robustness of the lightweight equipment emerging in the markets and can be used for objective and continuous assessment of mental fatigue. The main goal of this systematic review was to summarize the various eye-based features that have been used to measure mental fatigue and explore the relation of eye-based features to mental fatigue. The review process, following the preferred reporting items for systematic reviews and meta-analyses, used the electronic databases Web of Science, Scopus, ACM digital library, IEEE Xplore, and PubMed. Of the 1,385 retrieved documents, 34 studies met the inclusion criteria, resulting in 21 useful eye-based features. Categorizing these into eight groups revealed saccades as the most promising category, with saccade mean and peak velocity providing quick access to the cognitive states within 30 min of fatiguing activity. Complex brain networks involving sympathetic and parasympathetic nervous systems control the relation of mental fatigue to tonic pupil size and have the potential to indicate mental fatigue in controlled experimental conditions. Other categories, like blinks, are derived from the field of sleep research and should be used with caution. Several limitations emerged in the analysis, including varied experimental methods, use of dim lighting during the experiment (that could possibly also induce sleepiness), and use of unclear data analysis techniques, thereby complicating comparisons between studies.

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Section: Discussionmentioning

confidence: 99%

Mental fatigue measurement using eye metrics: A systematic literature review

Bafna

Hansen

2021

Psychophysiology

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“…The healthy control population were not asked questions which would enable evaluation of fatigue, caffeine intake or mental health diagnoses. Such factors have the potential to effect oculomotor function, these potential confounders weren't recorded in the disease groups either, but should be considered in future studies as they have potential to impact oculomotor parameters [36,37].…”

Section: Discussionmentioning

confidence: 99%

Eye Movement Biomarkers Allow for the Definition of Phenotypes in Gaucher Disease

Donald

Tan

Chakrapani

et al. 2020

Preprint

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Background Neurological forms of Gaucher disease, the inherited disorder of b-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with Enzyme Replacement Therapy (ERT), however, molecules which cross the blood-brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of ‘type 3’ Gaucher disease. MethodsWe undertook a study to evaluate saccadic eye movements in Gaucher patients and to assess the role of the EyeSeeCam in measuring saccades. The EyeSeeCam is a video oculography device which was used to run a protocol of saccade measures. We studied 39 patients with non-neurological Gaucher disease (type 1), 21 patients with type 3 (neurological) disease and a series of 35 healthy controls. Mean saccade parameters were compared across disease subgroups. ResultsWe confirmed the saccadic abnormality in patients with type 3 Gaucher disease andidentified an unexpected subgroup of patients with type 1 Gaucher disease who demonstrated significant saccade parameter abnormalities. These patients also showed subtle neurological findings and shared aGBA1 variant. ConclusionsThis striking novel finding of a potentially attenuated type 3 Gaucher phenotype associated with a specific GBA1 variant and detectable saccadic abnormality prompts review of current disease classification. Further, this finding highlights the broad spectrum of neuronopathic Gaucher phenotypes relevant when designing inclusion criteria for clinical trials.

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“…The saccadic slowing identified in the GD-T1 group however would not be thought to reflect age-related saccadic changes given the significant number of young adults they were found in. Other potential confounders; fatigue, caffeine intake or mental health diagnoses which may affect oculomotor function were not controlled for in either healthy controls or disease groups; these should be considered in future studies as they have potential to impact oculomotor parameters [43,44].…”

Section: Limitationsmentioning

confidence: 99%

Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease

Donald

Tan

Chakrapani

et al. 2020

Orphanet J Rare Dis

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Background Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease are effectively treated with enzyme replacement therapy, however, molecules which cross the blood–brain barrier are still under investigation. Clinical trials of such therapeutics require robust, reproducible clinical endpoints to demonstrate efficacy and clear phenotypic definitions to identify suitable patients for inclusion in trials. The single consistent clinical feature in all patients with neuronopathic disease is the presence of a supranuclear saccadic gaze palsy, in the presence of Gaucher disease this finding serves as diagnostic of ‘type 3’ Gaucher disease. Methods We undertook a study to evaluate saccadic eye movements in Gaucher patients and to assess the role of the EyeSeeCam in measuring saccades. The EyeSeeCam is a video-oculography device which was used to run a protocol of saccade measures. We studied 39 patients with non-neurological Gaucher disease (type 1), 21 patients with type 3 (neurological) disease and a series of 35 healthy controls. Mean saccade parameters were compared across disease subgroups. Results We confirmed the saccadic abnormality in patients with type 3 Gaucher disease and identified an unexpected subgroup of patients with type 1 Gaucher disease who demonstrated significant saccade parameter abnormalities. These patients also showed subtle neurological findings and shared a GBA1 variant. Conclusions This striking novel finding of a potentially attenuated type 3 Gaucher phenotype associated with a specific GBA1 variant and detectable saccadic abnormality prompts review of current disease classification. Further, this finding highlights the broad spectrum of neuronopathic Gaucher phenotypes relevant when designing inclusion criteria for clinical trials.

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Caffeine increases the velocity of rapid eye movements in unfatigued humans

Cited by 16 publications

References 47 publications

Mental fatigue measurement using eye metrics: A systematic literature review

Mental fatigue measurement using eye metrics: A systematic literature review

Eye Movement Biomarkers Allow for the Definition of Phenotypes in Gaucher Disease

Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease

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