Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9–10 year old children

Christensen, Zachary; Freedman, Edward G.; Foxe, John J.

doi:10.1016/j.neuropharm.2021.108479

Cited by 12 publications

(13 citation statements)

References 89 publications

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“…repeatedly reported the possible vulnerability to ASD-related behaviours in children descending from caffeine consuming mothers [ 109 , 110 ]. Moreover, Christensen et al [ 111 ] described several significant structural brain alterations and deleterious neurocognitive outcomes in children as being associated with caffeine consumption in pregnant women. Since the correlated changes were observed for the left corticospinal tract and left inferior fronto-occipital fasciculus (decreased neuronal density), it could be suggested that the gestational caffeine exposure interfered with the neurodevelopmental processes occurring in brain areas associated with working memory formation and visual stimuli perception [ 111 ].…”

Section: Autism and Schizophrenia Zebrafish Animal Modelsmentioning

confidence: 99%

“…Moreover, Christensen et al [ 111 ] described several significant structural brain alterations and deleterious neurocognitive outcomes in children as being associated with caffeine consumption in pregnant women. Since the correlated changes were observed for the left corticospinal tract and left inferior fronto-occipital fasciculus (decreased neuronal density), it could be suggested that the gestational caffeine exposure interfered with the neurodevelopmental processes occurring in brain areas associated with working memory formation and visual stimuli perception [ 111 ]. Also, some animal studies showed that gestational caffeine exposure could lead to hippocampal hyperexcitability and GABA neurons migration impairments [ 112 ].…”

Section: Autism and Schizophrenia Zebrafish Animal Modelsmentioning

confidence: 99%

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A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses

et al. 2022

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Neurodevelopmental disorders (NDDs) are complex disorders which can be associated with many comorbidities and exhibit multifactorial-dependent phenotypes. An important characteristic is represented by the early onset of the symptoms, during childhood or young adulthood, with a great impact on the socio-cognitive functioning of the affected individuals. Thus, the aim of our review is to describe and to argue the necessity of early developmental stages zebrafish models, focusing on NDDs, especially autism spectrum disorders (ASD) and also on schizophrenia. The utility of the animal models in NDDs or schizophrenia research remains quite controversial. Relevant discussions can be opened regarding the specific characteristics of the animal models and the relationship with the etiologies, physiopathology, and development of these disorders. The zebrafish models behaviors displayed as early as during the pre-hatching embryo stage (locomotor activity prone to repetitive behavior), and post-hatching embryo stage, such as memory, perception, affective-like, and social behaviors can be relevant in ASD and schizophrenia research. The neurophysiological processes impaired in both ASD and schizophrenia are generally highly conserved across all vertebrates. However, the relatively late individual development and conscious social behavior exhibited later in the larval stage are some of the most important limitations of these model animal species.

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Section: Autism and Schizophrenia Zebrafish Animal Modelsmentioning

confidence: 99%

Section: Autism and Schizophrenia Zebrafish Animal Modelsmentioning

confidence: 99%

A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses

et al. 2022

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“…After adjustment for potential confounders, maternal caffeine consumption reported at 22 weeks of gestation yielded no consistent associations with childhood neurodevelopment at any age. Christensen, et al 2021 Associations between maternal caffeine consumption and childhood neurodevelopment.…”

Section: Klebanoff and Keim 2015mentioning

confidence: 99%

“…Among a wide range of potential confounders, including marital status, ethnicity, employment status, and education level of one or both parents, maternal smoking and alcohol consumption have received particular attention. Of the nine human observational studies summarised in Table 1, all adjusted for cigarette smoking, and all but one [61] adjusted for alcohol consumption.…”

Section: Citationmentioning

confidence: 99%

Maternal caffeine consumption and childhood behavioural and neurocognitive development: A focused narrative review

James¹

2021

Arch Community Med Public Health

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Rationale:The majority of pregnant women regularly consume caffeine, a habit-forming substance of no nutritional value for mother or baby.Objectives: To examine evidence of association between maternal caffeine consumption and childhood behavioural and neurocognitive development, and to consider the soundness of current health guidance concerning the consumption of caffeine during pregnancy.Methods: Database searches identifi ed a large pool of peer-reviewed articles, which when culled for relevance yielded a modest corpus of animal and human research for inclusion in this focussed narrative review of potential caffeine-related threats to childhood behavioural and neurocognitive development.Results: High biological plausibility of potential harm from maternal caffeine exposure indicated by early animal research is confi rmed by more recent animal studies that sought to mimic human consumption patterns. Reported negative outcomes include increased neuronal network excitability and susceptibility to seizures in offspring, and disruptions to electrophysiological activity, learning, and memory. In contrast, human observational studies have yielded inconsistent fi ndings. Some studies have reported evidence of negative behavioural and neurocognitive outcomes, including hyperkinetic disorder, attention defi cit disorder, and intelligence level in preschool-and elementary-aged children. Other studies, however, reported no associations with maternal caffeine consumption for similar parameters.Conclusions: Current understanding of caffeine-related increased risk of harm for childhood development is limited due to inconsistent fi ndings from human research. However, persistent reports of possible negative outcomes indicate high priority need for further research. In the meantime, the cumulative scientifi c evidence supports advice to pregnant women and women contemplating pregnancy to avoid caffeine.

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“…Mimo że kawa działa prozdrowotnie na wielu płaszczyznach, nale ży zachować ostrożność w czasie ciąży. Najnowsze badania sugerują, że mimo iż spożywanie kofeiny podczas ciąży nie prowadzi do ostrych zaburzeń neuropsychiatrycznych, może zaburzać rozwój ścieżek neuronalnych i zmieniać organizację istoty białej w mózgu płodu, czego konsekwencją mogą być lekkie zaburzenia koncentracji lub nadaktywność w wieku szkolnym [45].…”

Section: Kofeina Czyli Naturalny Stymulantunclassified

Effect of nutrition on cognitive functions

Lis¹

2021

Med Og Nauk Zdr.

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Wprowadzenie i cel pracy. Procesy poznawcze warunkują prawidłowe funkcjonowanie organizmu, poprzez odbiór i analizę bodźców docierających ze środowiska. Odpowiednie żywienie stanowi podstawę profilaktyki deficytów poznawczych. Celem niniejszej pracy było opisanie wpływu diety na procesy poznawcze oraz związane z nimi zaburzenia. Metody przeglądu. W pracy dokonano analizy publikacji naukowych (m.in. metaanaliz, badań randomizowanych, przeglądów systematycznych) o tematyce medycznej i żywieniowej, z wyłączeniem case studies. Wyszukiwane przeprowadzono, korzystając z baz danych, takich jak PubMed, oraz korzystając z czasopism naukowych. Opis stanu wiedzy. Deficyty poznawcze objawiają się spadkiem wydajności i obniżeniem koncentracji. Najczęściej występują krótkotrwale i przemijają po ustaniu przyczyny. Mogą jednak stanowić objaw rozwijającej się choroby neurodegeneracyjnej. Wielość przyczyn powstawania zaburzeń poznawczych uniemożliwia całkowite ich wyeliminowanie lub zahamowanie. Czynnikami, na które mamy wpływ, są: masa ciała, żywność spożywana na co dzień, jakość mikroflory jelitowej oraz stosowane suplementy. Odpowiednio dobrana dieta, zawierająca m.in. witaminy z grupy B, przeciwutleniacze, produkty probiotyczne i nienasycone kwasy tłuszczowe, może tymczasowo poprawiać funkcje poznawcze oraz zapobiegać powstawaniu chorób neurodegeneracyjnych, które na dzień dzisiejszy są nieuleczalne. Obiecującą terapią uzupełniającą wydaje się być stosowanie probiotyków, jednak potwierdzenie tej tezy wymaga przeprowadzenia większej liczby badań. Podsumowanie. Kluczem do utrzymania sprawnych funkcji poznawczych jest kompleksowe dbanie o żywienie i zdrowy tryb życia. Skuteczność w zapobieganiu chorobom otępiennym jest szczególnie wysoka przed wystąpieniem pierwszych objawów. Odpowiednia dieta może zahamować rozwój chorób neurodegeneracyjnych, jednak nie wpływa na ich regresję.

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Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9–10 year old children

Cited by 12 publications

References 89 publications

A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses

A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses

Maternal caffeine consumption and childhood behavioural and neurocognitive development: A focused narrative review

Effect of nutrition on cognitive functions

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