Caffeine effects on resting-state electrodermal levels in AD/HD suggest an anomalous arousal mechanism

Barry, Robert J.; Clarke, Adam R.; McCarthy, Rory; Selikowitz, Mark; MacDonald, Brett; Dupuy, Franca E.

doi:10.1016/j.biopsycho.2012.01.004

Cited by 28 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lower SCL during baseline RT performance indicated a lower tonic level of peripheral arousal in individuals with ADHD, consistent with accounts of hypoarousal (14, 15, 16, 21, 49). No group differences emerged for SCR amplitude.…”

Section: Discussionsupporting

confidence: 78%

“…Increased SCL indexes an increase in peripheral arousal, whereas increased SCR amplitude indicates a stronger, higher intensity arousal response (6). Although early studies of SC in ADHD yielded conflicting findings (10, 11, 12, 13), a number of more recent studies, benefiting from advancements in SC technique, report attenuated SCL in children with ADHD at rest and in task conditions, indicating hypoarousal (14, 15, 16, 17, 18, 19, 20, 21). However, discrepancies still remain because some studies report no differences in SCL between adults with and without ADHD (22, 23).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times

James

Cheung

Rijsdijk

et al. 2016

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

BackgroundCognitive theories of attention-deficit/hyperactivity disorder (ADHD) propose that high within-subject fluctuations of cognitive performance in ADHD, particularly reaction time (RT) variability (RTV), may reflect arousal dysregulation. However, direct evidence of arousal dysregulation and how it may account for fluctuating RTs in ADHD is limited. We used skin conductance (SC) as a measure of peripheral arousal and aimed to investigate its phenotypic and familial association with RTV in a large sample of ADHD and control sibling pairs.MethodsAdolescents and young adults (N = 292), consisting of 73 participants with ADHD and their 75 siblings, and 72 controls and their 72 siblings, completed the baseline (slow, unrewarded) and fast-incentive conditions of a RT task, while SC was simultaneously recorded.ResultsA significant group-by-condition interaction emerged for SC level (SCL). Participants with ADHD had decreased SCL, compared with controls, in the baseline condition but not the fast-incentive condition. Baseline SCL was negatively associated with RTV, and multivariate model fitting demonstrated that the covariance of SCL with RTV, and of SCL with ADHD, was mostly explained by shared familial effects.ConclusionsADHD is associated with decreased, but modifiable, tonic peripheral arousal. A shared familial cause underlies the relationship between arousal and RTV and between arousal and ADHD. Given the malleability of SCL, if our findings are replicated, it warrants further exploration as a potential treatment target for ADHD.

show abstract

Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times

James

Cheung

Rijsdijk

et al. 2016

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Our study indicates that this may be also the case for autonomic baseline arousal, which was suggested by only a few studies so far (Lawrence et al 2005;Barry et al 2012). In addition, we revealed that this autonomic hypoarousal in ADHD is also prevalent in response towards stimuli of varying content and arousal.…”

Section: Valence and Arousal Ratingsmentioning

confidence: 49%

“…One measure to refl ect autonomic baseline arousal is the assessment of the skin conductance level (SCL) which indicates sympathetic nervous system activity (Boucsein 1992). Concerning this autonomic baseline arousal, few studies observed that ADHD is associated with an overall reduced skin conductance activity (Satterfi eld and Dawson 1971;Lazzaro et al 1999;Barry et al 2012); however, there are also contradictory results revealing normal autonomic activity during rest (Iaboni et al 1997). Studies found that cortical hypoarousal seems to be normalized by MPH (Clarke et al 2003) and one study suggests that MPH, unmedicated patients were automatically members of the ADHD no MPH group.…”

Section: Introductionmentioning

confidence: 95%

Autonomic hypoactivity in boys with attention-deficit/hyperactivity disorder and the influence of methylphenidate

Conzelmann

Gerdes

Mucha

et al. 2013

The World Journal of Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…4,5 These changes are peripheral (SCL) and central (EEG) markers of a simple increase in arousal. 6 This caffeine/arousal perspective provides the conceptual context for investigations of how caffeine affects stimulus processing, which we track using task-dependent event-related potentials (ERPs).…”

Section: Introductionmentioning

confidence: 99%

Caffeine Effects on ERP Components and Performance in an Equiprobable Auditory Go/NoGo Task

Barry

Blasio

Cave

2014

Journal of Caffeine Research

Self Cite

View full text Add to dashboard Cite

Research has reliably demonstrated that caffeine produces a general increase in physiological arousal in humans, but we previously failed to obtain the expected arousal-based changes in manually quantified event-related potential (ERP) components in response to the stimuli in a simple Go/NoGo task. A single oral dose of caffeine (250 mg) was used in a randomized double-blind placebo-controlled repeated-measures cross-over study. Adult participants (=24) abstained from caffeine for 4 hours before each of two sessions, approximately 1 week apart. An equiprobable auditory Go/NoGo task was used, with a random mix of 75 tones at 1,000 Hz and 75 at 1,500 Hz. All tones were 50 ms duration (rise/fall time 5 ms) at 60 dB SPL, with a fixed stimulus-onset asynchrony of 1100 ms. Principal component analysis (a form of factor analysis) was used to quantify orthogonal ERP components. ERP components reflected the different sequential processing of each stimulus type in this paradigm, replicating previous results. Caffeine was associated with a reduction in reaction time and fewer omission errors. The major ERP effects of caffeine were apparent as a slightly enhanced Processing Negativity and larger P3b amplitudes to Go stimuli. There were few effects on components to NoGo stimuli. The results confirm our previous findings that caffeine improves aspects of the differential processing related to response production and task performance, but may be interpreted as supporting the simple amplification of ERP component amplitudes predicted by the general arousal induced by caffeine.

show abstract

Caffeine effects on resting-state electrodermal levels in AD/HD suggest an anomalous arousal mechanism

Cited by 28 publications

References 16 publications

Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times

Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times

Autonomic hypoactivity in boys with attention-deficit/hyperactivity disorder and the influence of methylphenidate

Caffeine Effects on ERP Components and Performance in an Equiprobable Auditory Go/NoGo Task

Contact Info

Product

Resources

About