Caffeine effect in vestibular system

Ledesma, Alleluia Lima Losno; Barreto, Monique Antunes de Souza Chelminski; Bahmad, Fayez

doi:10.5935/0946-5448.20140011

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…On the basis of the literature we think that the most probable causes of a blocked GS in MD are sleep disorders, stress, 95 nicotine 95 and excitants abuse 96 water/salt balance dysregulation, 97 intestinal disorders. 98 On the basis of the Literature we think that the most probable causes of a blocked LS in MD are virus infections, 99 viral reactivations, 100 activation of viral inner ear epitopes, 101 systemic autoimmune diseases, 102 middle ear diseases, [103][104][105] allergies, 106 nasal disturbances, 107 food intolerances.…”

Section: Bridging the Gapmentioning

confidence: 99%

Bridging the gap between chronic cerebrospinal venous insufficiency and Ménière disease

Alpini

Bavera²,

Berardino

et al. 2016

Veins and Lymphatics

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Ménière disease (MD) is a chronic illness of the inner ear that affects a substantial number of patients every year worldwide. Because of a dearth of well-controlled studies, the medical and surgical management of MD remains quite empirical. The main reason is that it is very difficult to investigate patients affected with Certain MD due to the post-mortem criterion necessary for this diagnostic grade. Although Endolymphatic Hydrops (EH) is the worldwide accepted mechanism of MD, the causes that induce it are still not clear. In fact MD has been correlated mostly to a wide and different disturbances ranging from trauma to sleep disorders. It is nowadays sufficiently demonstrated that Chronic Cerebro Spinal Venous Insufficiency (CCSVI) is very frequent in MD. Even if CCSVI may potentially induce EH through a pure hydraulic mechanism CCSVI, per se does not explain how the various disorders correlated with MD may interact with CCSVI and provoke EH. The aim of this review is an attempt to approach MD into the context of the more recent findings about the global brain waste clearance system, to which inner ear is anatomically and functionally connected, in order to build a reasonable model of MD pathogenesis. The major part of the diseases correlated to MD may act on the inner ear disturbing the Glymphatic (GS) and/or Brain Lymphatic System (BLS) activity. The venous system interplays with GS and BLS. In this model CCSVI is considered more than a direct cause of MD rather the anatomical predisposition to develop the disease. In this model EH, and then MD, is the consequence of a failure of the compensation of the congenital venous abnormalities, anatomical compensation as collateral pathways and/or functional compensation as GS and BLS. In this model the major part of the disturbances correlated to MD and the various treatment proposed find their appropriate placement.

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Section: Bridging the Gapmentioning

confidence: 99%

Bridging the gap between chronic cerebrospinal venous insufficiency and Ménière disease

Alpini

Bavera²,

Berardino

et al. 2016

Veins and Lymphatics

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“…Given that caffeine has an excitatory effect on vestibular cells, 10 many studies have examined the relationship between caffeine consumption and the incidence of tinnitus. Although some reports have shown a positive relationship, 5 11 others failed to elucidate any association.…”

Section: Introductionmentioning

confidence: 99%

Does Caffeine Intake Increase the Incidence of Tinnitus? A Systematic Review

Aljuaid

Mirza

Habib

et al. 2020

Int Arch Otorhinolaryngol

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Introduction Excessive caffeine intake has been thought to be a contributory factor for tinnitus. However, there has been no systematic review to elucidate the causal relationship between caffeine intake and the incidence of tinnitus. Objectives We performed the current review aiming at evaluating the evidence from the current literature for the relationship between caffeine intake and the incidence of tinnitus. Data Synthesis Databases including PubMed, Scopus, and Google scholar were searched for relevant articles. A total of 142 studies were screened for eligibility, of which four articles met our inclusion criteria: two were prospective cohorts and two were cross-sectional studies. Although one study found no association between caffeine consumption and the incidence of tinnitus, an inverse relationship was reported by two population-based studies. Concerning patients with preexisting tinnitus, reduction of caffeine intake in a subset who consumed 150 ml to 300 ml/day of coffee yielded a favorable outcome in tinnitus severity. However, those with higher dose intake were less prone to have improvement in the severity of tinnitus. Conclusion Although the current review was inconclusive, it appears that the incidence of tinnitus in previously unaffected individuals might be prevented by a high dose of caffeine intake. However, in preexisting tinnitus, a high dose of caffeine may adversely interfere with the efficacy of caffeine reduction.

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