Caffeine consumption improves motor and cognitive performances during dual tasking in middle-aged women

Laatar, Rabeb; Waer, Fatma Ben; Rebai, Haithem; Sahli, Sonia

doi:10.1016/j.bbr.2021.113437

Cited by 5 publications

(6 citation statements)

References 56 publications

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“…Caffeine can be found in over sixty different plants, which usually contain other methylxanthines as well [ 5 , 6 ]. It has been used as a traditional beverage for thousands of years [ 7 , 8 ] and it is currently a very popular [ 9 , 10 ] physical [ 11 , 12 ] and cognitive [ 13 , 14 ] performance enhancer, although its immoderate consumption is related to some side effects [ 15 , 16 , 17 ]. Caffeine after oral intake is readily and completely absorbed from the small intestine [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Jeliński¹,

Cysewski²

2022

IJMS

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Solubility of active pharmaceutical ingredients is an important aspect of drug processing and formulation. Although caffeine was a subject of many studies aiming to quantify saturated solutions, many applied solvents suffer from not being environmentally friendly. This work fills this gap by presenting the results of solubility measurements in choline chloride natural deep eutectic solvents, ccNADES, comprising one of seven of the following polyalcohols: glycerol, sorbitol, xylitol, glucose, sucrose, maltose and fructose. The ratio of ccNADES components was optimized for maximizing caffeine solubility at room temperature. Additionally, temperature dependent solubility was measured for the first four systems exhibiting the highest solubility potential, both in their neat forms and in mixtures with water. Results were used for intermolecular interactions assessments using the COSMO-RS-DARE approach, which led to a perfect match between experimental and computed solubility values. An important methodological discussion was provided for an appropriate definition of the systems. Surprising linear trends were observed between the values of fitting parameters and water-ccNADES composition. In addition, comments on selection of the values of the fusion thermodynamic parameters were provided, which led to the conclusion that COSMO-RS-DARE solubility computations can effectively compensate for the inaccuracies of these important physicochemical properties.

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Section: Introductionmentioning

confidence: 99%

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Jeliński¹,

Cysewski²

2022

IJMS

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“…Although, according to our knowledge, there has not yet been a study evaluating caffeine effects on the balance and ambulatory performance of PwMS, previous studies have revealed caffeine’s potential benefits on balance and some aspects of gait performance in populations other than PwMS [ 28 – 30 , 62 , 63 ]. Notably, the results of these studies considerably vary by the study population’s age and sex.…”

Section: Discussionmentioning

confidence: 99%

“…Despite supportive evidence [ 18 – 20 , 23 , 24 , 28 – 30 ], to our knowledge, the potential effect of caffeine on balance and mobility in PwMS has not yet been studied. In this pilot single-arm phase II clinical trial we evaluated the potential effectiveness of caffeine ingestion on balance and mobility (i.e., static and dynamic balance, functional mobility, and patient’s reported ambulatory disability) among PwMS.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown caffeine’s potential benefits on various neurological disorders, including seizure, Alzheimer’s disease, Parkinson’s disease, stroke, and MS [ 18 – 25 ], possibly by reducing neuroinflammation and oxidative stress and increasing neurogenesis [ 26 , 27 ]. Specifically, research has highlighted the positive effects of caffeine on the ambulatory performance of non-MS populations [ 28 – 30 ], as well as on selected aspects of MS, including attention and disease progression [ 18 – 24 ]. Aligned with caffeine’s impact on the central nervous system, skeletal muscles [ 31 ], the ambulatory performance of non-MS populations [ 28 – 30 ], and specific aspects of MS [ 18 – 20 , 23 , 24 ], potentially favorable effects on balance and mobility in PwMS could also be anticipated.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, research has highlighted the positive effects of caffeine on the ambulatory performance of non-MS populations [ 28 – 30 ], as well as on selected aspects of MS, including attention and disease progression [ 18 – 24 ]. Aligned with caffeine’s impact on the central nervous system, skeletal muscles [ 31 ], the ambulatory performance of non-MS populations [ 28 – 30 ], and specific aspects of MS [ 18 – 20 , 23 , 24 ], potentially favorable effects on balance and mobility in PwMS could also be anticipated. Consequently, we hypothesized that caffeine might have the potential to improve balance and mobility impairments as debilitating aspects of MS.…”

Section: Introductionmentioning

confidence: 99%

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Potential efficacy of caffeine ingestion on balance and mobility in patients with multiple sclerosis: Preliminary evidence from a single-arm pilot clinical trial

Dadvar,

Jameie,

Azizmohammad Looha

et al. 2024

PLoS ONE

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Objectives Caffeine’s potential benefits on multiple sclerosis (MS), as well as on the ambulatory performance of non-MS populations, prompted us to evaluate its potential effects on balance, mobility, and health-related quality of life (HR-QoL) of persons with MS (PwMS). Methods This single-arm pilot clinical trial consisted of a 2-week placebo run-in and a 12-week caffeine treatment (200 mg/day) stage. The changes in outcome measures during the study period (weeks 0, 2, 4, 8, and 12) were evaluated using the Generalized Estimation Equation (GEE). The outcome measures were the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for self-reported ambulatory disability, Berg Balance Scale (BBS) for static and dynamic balance, Timed Up and Go (TUG) for dynamic balance and functional mobility, Multiple Sclerosis Impact Scale (MSIS-29) for patient’s perspective on MS-related QoL (MS-QoL), and Patients’ Global Impression of Change (PGIC) for subjective assessment of treatment efficacy. GEE was also used to evaluate age and sex effect on the outcome measures over time. (Iranian Registry of Clinical Trials, IRCT2017012332142N1). Results Thirty PwMS were included (age: 38.89 ± 9.85, female: 76.7%). Daily caffeine consumption significantly improved the objective measures of balance and functional mobility (BBS; P-value<0.001, and TUG; P-value = 0.002) at each study time point, and the subjective measure of MS-related QoL (MSIS-29; P-value = 0.005) two weeks after the intervention. Subjective measures of ambulatory disability (MSWS-12) and treatment efficacy (PGIC) did not significantly change. The effect of age and sex on the outcome measures were also assessed; significant sex-time interaction effects were found for MSWS-12 (P-value = 0.001) and PGIC (P-value<0.001). The impact of age on BBS scores increased as time progressed (P-value = 0.006). Conclusions Caffeine may enhance balance, functional mobility, and QoL in PwMS. Being male was associated with a sharper increase in self-reported ambulatory disability over time. The effects of aging on balance get more pronounced over time. Trial registration This study was registered with the Iranian Registry of Clinical Trials (Registration number: IRCT2017012332142N1), a Primary Registry in the WHO Registry Network.

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Caffeine and Anxiety-Like Behavior

Ribeiro‐Carvalho

Dutra-Tavares

Filgueiras

et al. 2022

Handbook of Substance Misuse and Addictions

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Caffeine consumption improves motor and cognitive performances during dual tasking in middle-aged women

Cited by 5 publications

References 56 publications

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

Potential efficacy of caffeine ingestion on balance and mobility in patients with multiple sclerosis: Preliminary evidence from a single-arm pilot clinical trial

Caffeine and Anxiety-Like Behavior

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