Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans

Landolt, Hans‐Peter; Rétey, Julia V.; Tönz, Karin; Gottselig, Julie M.; Khatami, Ramin; Buckelmüller, Isabelle; Achermann, Peter

doi:10.1038/sj.npp.1300526

Cited by 183 publications

(150 citation statements)

References 33 publications

(60 reference statements)

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“…Numerous reports have corroborated that adenosine is a neuromodulator that is involved in sleep regulation Benington et al, 1995;Porkka-Heiskanen et al, 1997;Radulovacki et al, 1982Radulovacki et al, , 1985Satoh et al, 1996Satoh et al, , 1999Scammell et al, 2001;Schwierin et al, 1996;Strecker et al, 2000;Ticho and Radulovacki, 1991;Urade et al, 2003). It has recently been proposed that in humans, caffeine mimics the effects of a reduction in sleep homeostasis during prolonged wakefulness (Landolt et al, 2004). Recently, we suggested that the amount of SWS or homeostatic pressure during recovery daytime sleep is critical to 'override' the circadian waking signal (Gaudreau et al, 2001).…”

Section: Discussionmentioning

confidence: 90%

“…Moderate doses of caffeine reduce reaction time on performance tasks, improve subjective alertness, and diminish self-reported fatigue and sleepiness (Landolt et al, 2004;Reyner and Horne, 2000;Van Dongen et al, 2001;Walsh et al, 1990;Warburton, 1995;Wyatt et al, 2004). Consequently, caffeine is consumed at different times of the day and night to help counteract the effects of sleep deprivation and circadian phase misalignment (jet lag, night work) on vigilance.…”

Section: Introductionmentioning

confidence: 99%

“…In humans, one study has shown minimal effects of caffeine on nocturnal recovery sleep after 64 h of sleep deprivation (Beaumont et al, 2005). Using quantitative sleep electroencephalogram (EEG), a recent study by Landolt et al (2004) has shown that the administration of two doses of caffeine during a 40-h sleep deprivation significantly reduces EEG power in the 0.75-2.0 Hz band and enhances power in the 11.25-20.0 Hz range relative to placebo during recovery night. Only two human studies have evaluated the effects of caffeine on daytime recovery sleep following one night of sleep deprivation (LaJambe et al, 2005;Muehlbach and Walsh, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Carrier

Fernandez‐Bolaños

Robillard

et al. 2006

Neuropsychopharmacol

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Caffeine is often used to counteract sleepiness generated by sleep deprivation, jet lag, and shift-work, and is consumed at different times of day. Caffeine also has effects on sleep. However, little is known about the interaction between sleep deprivation, circadian timing, and caffeine consumption on sleep. In this study, we compared the effects of caffeine on nocturnal sleep initiated at habitual circadian time and on daytime recovery sleep. Thirty-four moderate caffeine consumers participated in both caffeine (200 mg) and placebo (lactose) conditions in a double-blind crossover design. Seventeen subjects followed their habitual sleep-wake cycle and slept in the laboratory during the night (Night), while 17 subjects were sleep deprived for one night and recovery sleep started in the morning (DayRec). All subjects received a capsule of 100 mg of caffeine (or placebo) 3 h before bedtime, and the remaining dose 1 h before bedtime. Compared to placebo, caffeine lengthened sleep latency, increased stage 1, and reduced stage 2 and slow-wave sleep (SWS) in both groups. However, caffeine reduced sleep efficiency more strongly in the DayRec group, and decreased sleep duration and REM sleep only in that group. The stronger effects of caffeine on daytime recovery sleep compared to nocturnal sleep are probably the consequence of the combined influence of increasing circadian wake propensity drive and the dissipation of homeostatic sleep pressure. We propose that the reduction of SWS by caffeine during daytime sleep increases the impact of the circadian wake signal on sleep. These results have implications for individuals using caffeine during night time. Neuropsychopharmacology (2007) 32, 964-972.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Carrier

Fernandez‐Bolaños

Robillard

et al. 2006

Neuropsychopharmacol

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“…Based on these previous studies with modafinil and d-amphetamine, as well as the effects of the stimulant caffeine (Landolt et al 2004), and the effects of sleep deprivation under placebo it can be concluded that a reduction of delta and theta and enhancement of alpha activity are part of an alerting EEG signature. The effects of MK-0249 on the EEG to a large extent encompass this alerting EEG signature.…”

Section: )mentioning

confidence: 99%

Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

et al. 2011

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Rationale: Histamine and dopamine contribute to the maintenance of wakefulness.Objective: Exploratory analysis of the effects of 10 and 50 mg of MK-0249, a novel histamine subtype-3 receptor inverse agonist, and 200 mg of modafinil, a presumed dopaminergic compound, on EEG power spectra during sleep deprivation and subsequent recovery sleep. Methods: 25 healthy men were recruited to a double-blind placebocontrolled cross-over design. EEG power spectra, an electrophysiological marker of changes in sleepiness and vigilance, were obtained at the beginning of wake maintenance tests at 2 hourly intervals throughout a night and day of sleep deprivation, which is an established model of excessive sleepiness. Results: After placebo, sleep deprivation was associated with enhancements in delta, theta and reductions in alpha and beta activity.Following dosing at 02:00, MK-0249 and modafinil reduced delta and theta activity and enhanced alpha and beta activity, compared to placebo. During recovery sleep initiated at 21:00 h, latency to sleep onset, and number of awakenings were not different from placebo for any of the active treatments. Wake after sleep onset and stage 1 % was increased and total sleep time, SWS % and REM% were reduced after both doses of MK-0249. Compared to placebo, MK-0249 and the 50 mg dose in particular, reduced activity in some delta and theta/alpha frequencies and enhanced beta activity during NREM sleep and REM sleep.After modafinil, no changes were observed for power spectra during sleep. Conclusion: both MK-0249 and modafinil exert effects on the EEG which are consistent with wake promotion.

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“…The recording sessions were performed between 9 and 12 h in order to exclude an impact of circadian factors on the EEG. Subjects were advised to abstain from caffeinated beverages on the day of recording to avoid the caffeineinduced theta decrease in the EEG (Landolt et al, 2004). Before each recording, subjects were instructed to assume a comfortable position in a chair and were free to place their head on a chin-rest.…”

Section: Eeg Recording Sessionsmentioning

confidence: 99%

EEG alpha distinguishes between cuneal and precuneal activation in working memory

Michels¹,

et al. 2008

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EEG alpha distinguishes between cuneal and precuneal activation in working memory AbstractIn the literature on EEG during working memory (WM), the role of alpha power (8-13 Hz) during WM retention has remained unclear. We recorded EEG while 18 subjects retained sets of consonants in memory for 3 s; setsize (ss4, ss6, ss8) determines memory workload. Theta power (4-8 Hz) increased with workload in all subjects in middle frontal electrodes. Using ICA, the increase in theta could be attributed to one component whose generators were localized by sLORETA in the medial frontal gyrus. Alpha power in parietal electrode Pz showed a mean increase during retention as compared to prestimulus fixation (event-related synchronization, ERS). On an individual basis, alpha power increased with workload in 9 subjects (WL+ group) and decreased in 9 subjects (WL-group). The alpha increased in upper alpha for the WL+ group (mean: 10.4 Hz) and decreased in lower alpha for the WLgroup (mean: 8.9 Hz). Time-frequency representations show high alpha power early during retention for the WL+ group and high alpha power late during retention for the WL-group. sLORETA revealed maximal contrast for the WL+ group in the cuneus and for the WL-group in the precuneus. In subjects with WL+, alpha increase in the cuneus may reflect WM maintenance or active inhibition of task-irrelevant areas. In subjects with WL-, alpha decrease in the precuneus may reflect release of inhibition associated with attentional demands. Thus, alpha EEG characterizes two aspects of processing in the same WM task. EEG alpha distinguishes between cuneal and precuneal activation in working memoryLars In the literature on EEG during working memory (WM), the role of alpha power (8-13 Hz) during WM retention has remained unclear. We recorded EEG while 18 subjects retained sets of consonants in memory for 3 s; setsize (ss4, ss6, ss8) determines memory workload.Theta power (4-8 Hz) increased with workload in all subjects in middle frontal electrodes. Using ICA, the increase in theta could be attributed to one component whose generators were localized by sLORETA in the medial frontal gyrus.Alpha power in parietal electrode Pz showed a mean increase during retention as compared to prestimulus fixation (event-related synchronization, ERS). On an individual basis, alpha power increased with workload in 9 subjects (WL+ group) and decreased in 9 subjects (WL− group). The alpha increased in upper alpha for the WL+ group (mean: 10.4 Hz) and decreased in lower alpha for the WL− group (mean: 8.9 Hz). Time-frequency representations show high alpha power early during retention for the WL+ group and high alpha power late during retention for the WL− group. sLORETA revealed maximal contrast for the WL+ group in the cuneus and for the WL− group in the precuneus.In subjects with WL+, alpha increase in the cuneus may reflect WM maintenance or active inhibition of task-irrelevant areas. In subjects with WL−, alpha decrease in the precuneus may reflect release of inhibition associated with attention...

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Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans

Cited by 183 publications

References 33 publications

Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

EEG alpha distinguishes between cuneal and precuneal activation in working memory

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