Caffeine as an Active Adulterant: Implication for Drugs of Abuse Consumption

Scorza, Cecilia; Prieto, José Pedro; Fabius, Sara

doi:10.1007/978-3-030-67928-6_82-1

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…It is widely recognized as the most often taken pharmacologically active metabolite on a global scale. The molecule under consideration is a xanthine alkaloid, which exists in a white crystalline form [ [62] , [63] , [64] ]. It possesses a moderate bitterness and is recognized as a potent metabolic stimulant [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn

Hasan,

Haque,

Hoque

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn

Hasan,

Haque,

Hoque

et al. 2024

Heliyon

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“…Scientists have been fascinated by research in caffeine for decades. Caffeine ranks as one of the most frequently ingested active substances (Nawrot et al, 2003;Scorza et al, 2022). Apart from coffee, which serves as the commonest source, caffeine is usually present in prescription drugs, soft or energy drinks, gums, tea leaves, and stimulants (Mahoney et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats

Salami,

Kassim,

Allen

et al. 2023

ABS

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The study examines the impact of caffeine consumption during prepubertal development and recovery on the contractile function of the adult corpus cavernosum in Wistar rats. Prepubertal male rats consumed distilled water (vehicle) and caffeine (5 mg/kg). A third group consumed caffeine and was allowed a period of recovery. Cavernosa tissues were excised at adulthood, and their contractile functions in the presence of Ca2+, K+, indomethacin, glibenclamide, methyl blue, L-NAME, and sodium nitroprusside were assessed. K+-induced increase in contraction in the caffeine-treated group was similar to that in the recovery group. Ca2+ ions, however, increased contraction significantly in the caffeine group compared to the recovery group. Acetylcholine-mediated relaxation (%) was significantly higher in the recovery compared to the caffeine treated after incubation with indomethacin and methyl blue. Acetylcholine-mediated relaxation, however, was higher in caffeine as compared to the recovery group after incubation with glibenclamide and L-NAME. Relaxation in the presence of sodium nitroprusside was significantly reduced in recovery than in the caffeine-treated group. Prepubertal caffeine intake had an erectogenic effect on the cavernous tissues in the presence of glibenclamide, nifedipine, and L-NAME. Inhibitors of prostacyclin (indomethacin) and cGMP (methyl blue) militate caffeine-induced relaxation. Effects were reversed after recovery.

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Caffeine as an Active Adulterant: Implication for Drugs of Abuse Consumption

Cited by 2 publications

References 56 publications

Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn

Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn

Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats

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