Caffeine and the Kidney: What Evidence Right Now?

Bolignano, Davide; Coppolino, Giuseppe; Barillà, Antonio; Campo, Susanna; Criseo, Manila; Tripodo, Donatella; Buemi, Michele

doi:10.1053/j.jrn.2007.02.006

Cited by 35 publications

(21 citation statements)

References 63 publications

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“…In another vein, it has been shown that some coffee components, especially phenolics (chlorogenic acid, ferulic acid), have a great antioxidant capacity [6], and the consumption of coffee is associated with a small reduction in mortality in women with hepatic disease and/or cirrhosis and shows a protective effect on the liver in hepatic cancer [7]. Additionally, caffeine increases the production of urine with water and electrolyte secretion patterns very similar to those seen with the thiazides [8]. The underlying mechanisms may depend on various factors such as dose, chronic exposure, genetic and enzymatic factors, among others.…”

Section: Introductionmentioning

confidence: 99%

Caffeine's Vascular Mechanisms of Action

Echeverri

Móntes

Cabrera

et al. 2010

International Journal of Vascular Medicine

164

159

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Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.

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Section: Introductionmentioning

confidence: 99%

Caffeine's Vascular Mechanisms of Action

Echeverri

Móntes

Cabrera

et al. 2010

International Journal of Vascular Medicine

164

159

View full text Add to dashboard Cite

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“…Nevertheless, the data has not shown a link to heat illness and increased risk of dehydration [12,13]. However, caffeine has diuretic as well as stimulant properties [14]. Hence, excessive use (particularly in combination with additional caffeine from exogenous supplements) among soldiers operating in desert environments in heavy clothing suggests the need for caution and its sensible use [2,15].…”

Section: Discussionmentioning

confidence: 99%

The Use of Exercise and Dietary Supplements Among British Soldiers in Afghanistan

Boos

Simms

Morris³

et al. 2011

J R Army Med Corps

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A significant proportion of the British servicemen employed on operations in Afghanistan who were sampled, admitted to current dietary and exercise supplement use whilst on deployment. The results of this small study suggest that their use on operations may be increasing. Smoking rates and caffeine consumption, on deployment, remain high in the British military. A larger detailed study with greater representation among soldiers deployed to forward operating bases would be helpful to fully appreciate the scale of supplement use.

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“…42 Methylxanthines, such as theophylline and caffeine, are known diuretics and act as adenosine receptor antagonists. 43 Theophylline has also been used in the treatment of asthma; however, because of its small therapeutic window and requirement for frequent monitoring of serum levels, it has been largely replaced by other bronchodilators. 44 …”

Section: Properties and Clinical Use Of Adenosinementioning

confidence: 99%