Caffeine and risk of atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study

Frost, Lars; Vestergaard, Peter

doi:10.1093/ajcn/81.3.578

Cited by 122 publications

(85 citation statements)

References 20 publications

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“…Prospective studies have not found significant associations between coffee consumption and the risk of coronary heart disease [24,25]. Contrary to public belief, caffeine intake of 500-600 mg daily does not increase the risk, frequency, or severity of cardiac arrhythmias [26,27]. Indeed, there is a growing list of age-related diseases wherein habitual caffeine intake of 400-600 mg (4-6 cups of coffee) daily reduces the risk.…”

Section: Discussionmentioning

confidence: 99%

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

Arendash

Cao

2010

JAD

162

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Abstract. Epidemiologic studies have increasingly suggested that caffeine/coffee could be an effective therapeutic against Alzheimer's disease (AD). We have utilized a transgenic mouse model for AD in well-controlled studies to determine if caffeine and/or coffee have beneficial actions to protect against or reverse AD-like cognitive impairment and AD pathology. AD mice given caffeine in their drinking water from young adulthood into older age showed protection against memory impairment and lower brain levels of the abnormal protein (amyloid-β; Aβ) thought to be central to AD pathogenesis. Moreover, "aged" cognitively-impaired AD mice exhibited memory restoration and lower brain Aβ levels following only 1-2 months of caffeine treatment. We believe that the cognitive benefits of chronic caffeine administration in AD mice are due to caffeine itself, and not metabolites of caffeine; this, because our long-term administration of theophylline to AD mice provided no cognitive benefits. In acute studies involving AD mice, one oral caffeine treatment quickly reduced both brain and plasma Aβ levels -similarly rapid alterations in plasma Aβ levels were seen in humans following acute caffeine administration. "Caffeinated" coffee provided to AD mice also quickly decreased plasma Aβ levels, but not "decaffeinated" coffee, suggesting that caffeine is critical to decreasing blood Aβ levels. Caffeine appears to provide its disease-modifying effects through multiple mechanisms, including a direct reduction of Aβ production through suppression of both β-and γ-secretase levels. These results indicate a surprising ability of moderate caffeine intake (the human equivalent of 500 mg caffeine or 5 cups of coffee per day) to protect against or treat AD in a mouse model for the disease and a therapeutic potential for caffeine against AD in humans.

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Section: Discussionmentioning

confidence: 99%

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

Arendash

Cao

2010

JAD

162

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“…However, the ability of LCCs to open in response to much lower caffeine concentrations (e.g., 200 M) is pathophysiologically relevant. Heavy coffee drinkers can ingest an average of 1,000 mg of caffeine daily (14), which can bring their serum caffeine concentration close to toxic levels [Ͼ129 M (24)]. Such a toxic level can also be reached when someone accidentally uses an excessive amount of caffeine-containing substances (3).…”

Section: Effect Of Opening Caffeine-activated Lccsmentioning

confidence: 99%

Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance

Zhang¹,

Tuft²,

Lifshitz³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Caffeine-activated, large-conductance, nonselective cation channels (LCCs) have been found in the plasma membrane of isolated cardiac myocytes in several species. However, little is known about the effects of opening these channels. To examine such effects and to further understand the caffeine-activation mechanism, we carried out studies using whole-cell patch-clamp techniques with freshly isolated cardiac myocytes from rats and mice. Unlike previous studies, thapsigargin was used so that both the effect of opening LCCs and the action of caffeine were independent of Ca2+ release from intracellular stores. These Ca2+-permeable LCCs were found in a majority of the cells from atria and ventricles, with a conductance of ∼370 pS in rat atria. Caffeine and all its direct metabolic products (theophylline, theobromine, and paraxanthine) activated the channel, while isocaffeine did not. Although they share some similarities with ryanodine receptors (RyRs, the openings of which give rise to Ca2+ sparks), LCCs also showed some different characteristics. With simultaneous Ca2+ imaging and current recording, the localized fluorescence increase due to Ca2+ entry through a single opening of an LCC (SCCaFT) was detected. When membrane potential, instead of current, was recorded, SCCaFT-like fluorescence transients (indicating single LCC openings) were found to accompany membrane depolarizations. To our knowledge, this is the first report directly linking membrane potential changes to a single opening of an ion channel. Moreover, these events in cardiac cells suggest a possible additional mechanism by which caffeine and theophylline contribute to the generation of cardiac arrhythmias.

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“…Previous studies have pointed out that caffeine overdose causes various kinds of arrhythmias, [1][2][3] including atrial tachycardia. 4) Josephson, et al 4) reported a case of paroxysmal atrial tachycardia in a 42-year-old man with asymptomatic aortic regurgitation, after increased amounts of coffee consumption (30 cups a day) in addition to tea and cola.…”

Section: Discussionmentioning

confidence: 99%

A Case of Atrial Tachycardia Sensitive to Increased Caffeine Intake

Kinugawa¹,

Kurita

Nohara

et al. 2011

Int. Heart J.

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SummaryA 33-year-old Japanese man with atrial tachycardia visited our clinic. He regularly consumed daily alcohol with cola, one cup of regular coffee, and a candy containing 0.7 mg of caffeine per tablet. After stopping his caffeine intake, his arrhythmia ameliorated. Since caffeine might be associated with his arrhythmia, a caffeine load test (equivalent to his daily intake of caffeine) was performed for 4 days. Atrial tachycardia time from a Holter recording was 44.2 minute/day before the caffeine load, compared with 215.2 minute/day during the caffeine load. Plasma caffeine concentration before and during caffeine loading was 3.1 mg/dL and 5.4 mg/dL, respectively. Caffeine use seemed to be an important factor for his atrial tachycardia, since his arrhythmia became worse during caffeine load testing and was ameliorated after the cessation of caffeine. (Int Heart J 2011; 52: 398-400) Key words: Atrial tachycardia, Caffeine, Holter monitoring, Caffeine load test C affeine intake is usually safe in most normal subjects and cardiac patients in terms of cardiac arrhythmias. However, there are patients who are caffeine-sensitive and who will experience an aggravation of ventricular or atrial arrhythmias. Reports have described a link between arrhythmia and caffeine use, but a true association between the two is often not demonstrated. In this case report, we present a unique case in that the exacerbation of atrial tachycardia was associated with his caffeine intake. We performed caffeine load test and demonstrated that his arrhythmia became apparent during modest intake of caffeine with non-toxic plasma levels. Case ReportA 33-year-old Japanese man visited our clinic for an arrhythmia work-up due to symptoms. The previous week he underwent surgery for a foreskin cyst under lumbar anesthesia after which he experienced recurrent palpitations associated with tachycardia in which heart rate was consistently over 100-110 beats per minute (bpm). Physical examination revealed no remarkable findings except for an irregular rapid heart beat. His BMI was 22.7, his blood pressure was 146/96 mmHg, and a chest X-ray showed no cardiomegaly. Echocardiogram revealed no organic heart disease and a left ventricular ejection fraction of 62.4%. A 12-lead ECG (Figure 1) revealed atrial tachycardia with a mean heart rate of 103 bpm. Further examination revealed a PP interval of 460 msec in V 1 lead. His heart rate decreased to 88 bpm upon application of carotid sinus massage. Subsequent 24-hour Holter monitoring showed frequent atrial tachycardia with heart rates consistently at 110 bpm or greater (Figure 2, upper panel left). The rapid heart rate continued all day as shown in the heart rate periodogram (Figure 2, upper panel right).Detailed anamnesis revealed eating habits that included daily consumption of caffeine that involved consumption of alcohol with cola (500 mL/day), one cup of regular coffee, and consumption of 20 tablets of candy containing 0.7 mg of caffeine per tablet (MINTIA Dry Hard: Asahi Food and Health Care Co., Ltd)....

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Caffeine and risk of atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study

Abstract: Consumption of caffeine was not associated with risk of atrial fibrillation or flutter.

Cited by 122 publications

References 20 publications

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance

A Case of Atrial Tachycardia Sensitive to Increased Caffeine Intake

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