Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors

Babey, A. M.; Palmour, Roberta M.; Young, Simon N.

doi:10.1016/0304-3940(94)90879-6

Cited by 12 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others found that caffeine increased endogenous serum melatonin levels (Ursing et al, 2003), or serum melatonin levels following oral melatonin administration (Härtter et al, 2003), through competitively inhibiting hepatic melatonin breakdown by the cytochrome P450 isoform CYP1A2. In rats caffeine decreased melatonin levels in the presence of an adenosine receptor agonist, but no effect on melatonin levels was observed with caffeine by itself (Babey et al, 1994). However, another study determined that caffeine increased melatonin levels in rat by increasing the activity of the rate limiting enzyme of melatonin synthesis, serotonin N-acetyltransferase (Sabry, 1997).…”

Section: The Effect Of Caffeine On Serum Melatonin Levelsmentioning

confidence: 95%

Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

et al. 2012

View full text Add to dashboard Cite

Section: The Effect Of Caffeine On Serum Melatonin Levelsmentioning

confidence: 95%

Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

et al. 2012

View full text Add to dashboard Cite

“…Caffeine acts as an adenosine receptor antagonist. Adenosine increases intracellular cAMP levels via adenosine receptor, which increases the production of AANAT, the rate limiting enzyme in melatonin synthesis (53). Thus as adeosine receptors are blocked by caffeine, the synthesis of melatonin decreases.…”

Section: Dietary Compoundsmentioning

confidence: 99%

Dietary factors and fluctuating levels of melatonin

Peuhkuri

Sihvola²,

Korpela³

2012

Food & Nutrition Research

143

107

View full text Add to dashboard Cite

Melatonin is secreted principally by the pineal gland and mainly at nighttime. The primary physiological function is to convey information of the daily cycle of light and darkness to the body. In addition, it may have other health-related functions. Melatonin is synthesized from tryptophan, an essential dietary amino acid. It has been demonstrated that some nutritional factors, such as intake of vegetables, caffeine, and some vitamins and minerals, could modify melatonin production but with less intensity than light, the most dominant synchronizer of melatonin production. This review will focus on the nutritional factors apart from the intake of tryptophan that affect melatonin levels in humans. Overall, foods containing melatonin or promoting the synthesis of it by impacting the availability of tryptophan, as well those containing vitamins and minerals which are needed as co-factors and activators in the synthesis of melatonin, may modulate the levels of melatonin. Even so, the influence of daytime diet on the synthesis of nocturnal melatonin is limited, however, the influence of the diet seems to be more obvious on the daytime levels.

show abstract

“…Several previous studies have addressed that the regulation of pineal functions depends on a variety of first messengers including the nucleoside adenosine (Ebadi & Govitrapong, 1986). Studies of rat pinealocytes have shown that NECA stimulates cyclic AMP accumulation and melatonin synthesis by acting on A 2B ‐adenosine receptors which have been linked to the activation of adenylyl cyclase (Nikodijevic & Klein, 1989; Babey et al ., 1994). In cultured chicken pinealocytes, nonmetabolizable adenosine analogues exerted an inhibitory action on pineal melatonin production elicited by forskolin probably via the A 1 adenosine receptors (Falcon et al ., 1988a).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of adenosine receptors in PGT‐β mouse pineal gland tumour cells

Suh

Kim

Lee

et al. 2001

British J Pharmacology

View full text Add to dashboard Cite

1 The adenosine receptor in mouse pinealocytes was identi®ed and characterized using pharmacological and physiological approaches. 2 Expression of the two adenosine receptor subtypes A 2B and A 3 was detected in mouse pineal glands and PGT-b cells by polymerase chain reaction and nucleotide sequencing. 6 These data suggest the presence of both A 2B and A 3 adenosine receptors in mouse pineal tumour cells and that the A 2B receptor is positively coupled to adenylyl cyclase whereas the A 3 receptor is negatively coupled to adenylyl cyclase and also coupled to phospholipase C.

show abstract

Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors

Cited by 12 publications

References 12 publications

Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

Dietary factors and fluctuating levels of melatonin

Pharmacological characterization of adenosine receptors in PGT‐β mouse pineal gland tumour cells

Contact Info

Product

Resources

About