Caffeine and nicotine: A review of their joint use and possible interactive effects in tobacco withdrawal

Swanson, James A.; Lee, Jerry; Hopp, Joyce W.

doi:10.1016/0306-4603(94)90027-2

Cited by 160 publications

(122 citation statements)

References 106 publications

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“…It is known that smoking induces the enzyme cytochrome P450 1A2 (CYP1A2) (the main enzyme involved in caffeine metabolism), and therefore increases metabolism of caffeine 21, 22. It is also possible that constituents of coffee may have a pharmacological impact on the actions or metabolism of nicotine 1. Previous in‐vitro research has shown that caffeic acid and quercetin, compounds present in coffee, unrelated to caffeine, inhibit bovine cytochrome P450 2A6 (CYP2A6) enzyme activity 23.…”

Section: Discussionmentioning

confidence: 99%

“…Coffee consumption is associated with smoking 1, 2, 3. Observational studies show that coffee drinkers are more likely to be smokers than non‐consumers 2, 3 and smoke more heavily 1.…”

Section: Introductionmentioning

confidence: 99%

“…Observational studies show that coffee drinkers are more likely to be smokers than non‐consumers 2, 3 and smoke more heavily 1. This may arise via a number of possible mechanisms—constituents of coffee may have a pharmacological impact on the actions or metabolism of nicotine, or conditioning processes may lead to learned associations between the consumption of one and the other 1. Given the widespread use of coffee world‐wide, and the substantial health burden posed by cigarette smoking, determining the potential causal impact of coffee consumption on smoking behaviour is of clear public health importance.…”

Section: Introductionmentioning

confidence: 99%

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Does coffee consumption impact on heaviness of smoking?

et al. 2017

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Background and AimsCoffee consumption and cigarette smoking are strongly associated, but whether this association is causal remains unclear. We sought to: (1) determine whether coffee consumption influences cigarette smoking causally, (2) estimate the magnitude of any association and (3) explore potential mechanisms.DesignWe used Mendelian randomization (MR) analyses of observational data, using publicly available summarized data from the Tobacco and Genetics (TAG) consortium, individual‐level data from the UK Biobank and in‐vitro experiments of candidate compounds.SettingThe TAG consortium includes data from studies in several countries. The UK Biobank includes data from men and women recruited across England, Wales and Scotland.ParticipantsThe TAG consortium provided data on n ≤ 38 181 participants. The UK Biobank provided data on 8072 participants.MeasurementsIn MR analyses, the exposure was coffee consumption (cups/day) and the outcome was heaviness of smoking (cigarettes/day). In our in‐vitro experiments we assessed the effect of caffeic acid, quercetin and p‐coumaric acid on the rate of nicotine metabolism in human liver microsomes and cDNA‐expressed human CYP2A6.FindingsTwo‐sample MR analyses of TAG consortium data indicated that heavier coffee consumption might lead to reduced heaviness of smoking [beta = −1.49, 95% confidence interval (CI) = −2.88 to −0.09]. However, in‐vitro experiments found that the compounds investigated are unlikely to inhibit significantly the rate of nicotine metabolism following coffee consumption. Further MR analyses in UK Biobank found no evidence of a causal relationship between coffee consumption and heaviness of smoking (beta = 0.20, 95% CI = –1.72 to 2.12).ConclusionsAmount of coffee consumption is unlikely to have a major causal impact upon amount of cigarette smoking. If it does influence smoking, this is not likely to operate via effects of caffeic acid, quercetin or p‐coumaric acid on nicotine metabolism. The observational association between coffee consumption and cigarette smoking may be due to smoking impacting on coffee consumption or confounding.

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Section: Discussionmentioning

confidence: 99%

“…Coffee consumption is associated with smoking 1, 2, 3. Observational studies show that coffee drinkers are more likely to be smokers than non‐consumers 2, 3 and smoke more heavily 1.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does coffee consumption impact on heaviness of smoking?

et al. 2017

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“…As with the subjective ratings, cardiovascular measures did not differ between the maintenance phases. These observations are interesting given that epidemiological studies have shown that cigarette smokers consume more caffeine than nonsmokers (Istvan and Matarazzo, 1984;Swanson et al, 1994). Although previous studies have shown that caffeine can enhance the reinforcing effects of nicotine (Shoaib et al, 1999;Jones and Griffiths, 2003), no study has evaluated whether nicotine enhances the reinforcing effects of caffeine.…”

Section: Effects Of Nicotine Maintenance On Intravenous Caffeinementioning

confidence: 99%

“…Epidemiological studies have demonstrated a strong concordance between tobacco and caffeine use (Istvan and Matarazzo, 1984;Swanson et al, 1994), and preclinical and clinical studies have shown that chronic caffeine administration potentiates the stimulant and reinforcing effects of nicotine (Tanda and Goldberg, 2000;Jones and Griffiths, 2003).…”

Section: Introductionmentioning

confidence: 99%

Transdermal Nicotine Maintenance Attenuates the Subjective and Reinforcing Effects of Intravenous Nicotine, but not Cocaine or Caffeine, in Cigarette-Smoking Stimulant Abusers

Sobel

Sigmon

Griffiths

2004

Neuropsychopharmacol

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The effects of transdermal nicotine maintenance on the subjective, reinforcing, and cardiovascular effects of intravenously administered cocaine, caffeine, and nicotine were examined using double-blind procedures in nine volunteers with histories of using tobacco, caffeine, and cocaine. Each participant was exposed to two chronic drug maintenance phases (21 mg/day nicotine transdermal patch and placebo transdermal patch). Within each drug phase, the participant received intravenous injections of placebo, cocaine (15 and 30 mg/70 kg), caffeine (200 and 400 mg/70 kg), and nicotine (1.0 and 2.0 mg/70 kg) in mixed order across days. Subjective and cardiovascular data were collected before and repeatedly after drug or placebo injection. Reinforcing effects were also assessed after each injection with a Drug vs Money Multiple-Choice Form. Intravenous cocaine produced robust dose-related increases in subjective and reinforcing effects; these effects were not altered by nicotine maintenance. Intravenous caffeine produced elevations on several subjective ratings; nicotine maintenance did not affect these ratings. Under the placebo maintenance condition, intravenous nicotine produced robust dose-related subjective effects, with maximal increases similar to the high dose of cocaine; nicotine maintenance significantly decreased the subjective and reinforcing effects of intravenous nicotine. The results of the present study demonstrate that chronic nicotine maintenance produces tolerance to the effects of intravenous nicotine, but does not affect the subjective or reinforcing effects of cocaine or caffeine.

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Substance Use and Addictive Disorders: Caffeine

Meredith

Griffiths

2015

Psychiatry

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Caffeine and nicotine: A review of their joint use and possible interactive effects in tobacco withdrawal

Cited by 160 publications

References 106 publications

Does coffee consumption impact on heaviness of smoking?

Does coffee consumption impact on heaviness of smoking?

Transdermal Nicotine Maintenance Attenuates the Subjective and Reinforcing Effects of Intravenous Nicotine, but not Cocaine or Caffeine, in Cigarette-Smoking Stimulant Abusers

Substance Use and Addictive Disorders: Caffeine

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