Caffeine and hypertension

Robertson, David; Hollister, Alan S.; Kincaid, Dawn; Workman, Robert J.; Goldberg, Michael R.; Tung, Che‐Se; Smith, Bolton

doi:10.1016/0002-9343(84)90435-2

Cited by 85 publications

(43 citation statements)

References 17 publications

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“…Acutely administered caffeine increased plasma renin activity in experimental animals (Ohnishi et al, 1987) and in man (Robertson et al, 1978(Robertson et al, , 1981, probably through the antagonism of adenosine receptors on juxtaglomerular cells (Kuan et al, 1990). In some studies, however, no signi®cant effect of acute caffeine intake on plasma renin activity was observed (Passmore et al, 1987;Nussberger et al, 1990), or else the increase was attenuated after chronic administration of caffeine (Robertson et al, 1981(Robertson et al, , 1984Eggertsen et al, 1993). A decrease in plasma renin activity after an acute intake of coffee has also been reported (Smits et al, 1983(Smits et al, , 1986a.…”

Section: Renal Effectsmentioning

confidence: 91%

“…Most of the long-term studies were of normotensive subjects, and there is relatively little information on the long-term effects of caffeine in hypertensive patients (Robertson et al, 1984;MacDonald et al, 1991;Eggertsen et al, 1993;Rakic et al, 1999).…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

“…The pressor response has been reported as diminishing within a few days of the start of regular intake of caffeine (Robertson et al, 1981(Robertson et al, , 1984Ammon et al, 1983;Myers & Reeves, 1991). However, the tolerance may be partial, because in some studies caffeine was still able to elevate blood pressure during habitual consumption (Burr et al, 1989;Jeong & Dimsdale 1990;James 1994;Green & Suls, 1996).…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

“…The pressor effect has often been accompanied by a small decrease in the heart rate (Izzo et al, 1983;Smits et al, 1983Smits et al, , 1985Smits et al, , 1986aRobertson et al, 1984;Sung et al, 1994), or heart rate was not sign®cantly affected even after high doses of caffeine (Robertson et al, 1981;Ammon et al, 1983;Casiglia et al, 1992;Bender et al, 1997). The caffeineinduced lowering of the heart rate may be a re¯ectory bradycardic response to pressor action or a direct effect on the cardiac or sino-atrial node.…”

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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Objective: We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine. Design: The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words`coffee or caffeine' and`blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine. Results: Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory ®ndings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown. Conclusions:We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been suf®ciently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.

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Section: Renal Effectsmentioning

confidence: 91%

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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“…They also stimulate central noradrenergic activity (Berkowitz et al, 1970). In caffeine-naive subjects they produce a dose related increase in plasma noradrenaline (Robertson et al, 1978), although not in habitual caffeine users (Robertson et al, 1984). However, the most potent central effect is at the adenosine receptor site .…”

Section: Caffeinementioning

confidence: 99%

States of anxiety and their induction by drugs.

Lader¹,

Bruce²

1986

Brit J Clinical Pharma

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Syndromes of anxiety include generalized anxiety states, various forms of phobic disorder and panic attacks. It is unclear whether panic attacks are a separate syndrome from anxiety states or a more severe form. Drug‐induced states of anxiety should provide useful models of the mechanisms of anxiety and its treatment. High‐risk populations might be identifiable. Catecholamine infusions produce marked peripheral changes without fully reproducing the central feelings. Lactate infusions also produce anxiety‐like states lacking full credibility. Experience with the benzodiazepine‐receptor contragonists, the beta‐carbolines, is limited but panic states have been reproduced following their use. Caffeine produces an anxiety state in high dose and some panic states have been induced. The critical evaluation of drug‐induced anxiety states is a promising way of elucidating the mechanisms, psychological and physiological, associated with clinical anxiety.

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