Caffeine and Cognitive Decline in Elderly Women at High Vascular Risk

Vercambre, Marie-Noël; Berr, Claudine; Ritchie, Karen; Kang, Jae H.

doi:10.3233/jad-122371

Cited by 54 publications

(41 citation statements)

References 42 publications

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“…Besides, caffeine can act against neurodegenerative changes in the brain via positive effects on serum lipids [47,48]. For another example, a recent observational study demonstrated that caffeine intake had a better cognitive maintenance in 2,475 elderly women with concomitant cardiovascular diseases or ≥3 coronary risk factors (i.e., diabetes, hypertension, hyperlipidemia, or obesity) [49]. …”

Section: Discussionmentioning

confidence: 99%

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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Background: Observational epidemiological studies such as cross-sectional, case-control, and cohort studies have reported inconsistent findings regarding the association between caffeine intake from coffee or tea and the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Methods: We searched PubMed and EMBASE in September 2014. Three evaluators independently extracted and reviewed articles, based on predetermined selection criteria. Results: Out of 293 articles identified through the search and bibliographies of relevant articles, 20 epidemiological studies from 19 articles, which involved 31,479 participants (8,398 in six cross-sectional studies, 4,601 in five case-control studies, and 19,918 in nine cohort studies), were included in the final analysis. The pooled odds ratio (OR) or relative risk (RR) of caffeine intake from coffee or tea for cognitive disorders (dementia, Alzheimer's disease, cognitive impairment, and cognitive decline) was 0.82 (95% confidence interval [CI], 0.67-1.01, I² = 63.2%) in a random-effects meta-analysis. In the subgroup meta-analysis by caffeine sources, the summary OR or RR of coffee intake was 0.83 (95% CI, 0.70-0.98; I² = 44.8%). However, in the subgroup meta-analysis by study design, the summary estimates (RR or OR) of coffee intake for cognitive disorders were 0.70 (95% CI, 0.50-0.98; I² = 42.0%) for cross-sectional studies, 0.82 (95% CI, 0.55-1.24; I² = 33.4%) for case-control studies, and 0.90 (95% CI, 0.59-1.36; I² = 60.0%) for cohort studies. Conclusions: This meta-analysis found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders.

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Section: Discussionmentioning

confidence: 99%

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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“…Findings from the Cardiovascular Health Study (CHS) on 4,809 participants aged 65 and older also suggested a modestly reduced rates of cognitive decline assessed with the modified MMSE (3MS) over a median follow up of 7.9 years for some, but not all, levels of coffee and tea consumption for women (57). Furthermore, for 2,475 women aged 65+ years in the Women's Antioxidant Cardiovascular Study, higher caffeine intake (approximately 4 cups of coffee/day) was related to moderately better cognitive maintenance over 5 years in older women with vascular disorders (60). Finally, also in the longitudinal component of the SLAS, a more frequent tea consumption of all kinds was associated with a lower risk of cognitive decline in a follow-up of 1-2 years (44), while in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), daily tea drinking was associated with better cognitive function measured by verbal fluency test during a 7-year followup period on 7,139 participants aged 80 to 115 years (59).…”

Section: Longitudinal Studiesmentioning

confidence: 99%

“…cross-sectional (41)(42)(43)(44)(45)(46)(47)(48)(49)(50) and longitudinal (44,(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61) populationbased studies suggested a protective effect of coffee, tea, or caffeine use against cognitive impairment/decline, although, the association was not found in all cognitive domains investigated ( Table 3). The findings on the association of coffee, tea, and caffeine consumption or plasma caffeine levels with incident MCI and its progression to dementia were too limited to draw any conclusion (55,61) (Table 3).…”

Section: The Journal Of Nutrition Health and Aging© J Nutr Health Agingmentioning

confidence: 99%

Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

Panza

Solfrizzi

Barulli

et al. 2015

The Journal of nutrition, health and aging

156

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A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer's disease (AD) and the symptoms of advanced AD may represent a unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression are becoming mandatory. Among possible reversible risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors were associated with the development of dementia and late-life cognitive disorders, opening new avenues for the prevention of these diseases. Among diet-associated factors, coffee is regularly consumed by millions of people around the world and owing to its caffeine content, it is the best known psychoactive stimulant resulting in heightened alertness and arousal and improvement of cognitive performance. Besides its short-term effect, some case-control and cross-sectional and longitudinal population-based studies evaluated the long-term effects on brain function and provided some evidence that coffee, tea, and caffeine consumption or higher plasma caffeine levels may be protective against cognitive impairment/decline and dementia. In particular, several cross-sectional and longitudinal population-based studies suggested a protective effect of coffee, tea, and caffeine use against late-life cognitive impairment/decline, although the association was not found in all cognitive domains investigated and there was a lack of a distinct dose-response association, with a stronger effect among women than men. The findings on the association of coffee, tea, and caffeine consumption or plasma caffeine levels with incident mild cognitive impairment and its progression to dementia were too limited to draw any conclusion. Furthermore, for dementia and AD prevention, some studies with baseline examination in midlife pointed to a lack of association, although other case-control and longitudinal population-based studies with briefer follow-up periods supported favourable effects of coffee, tea, and caffeine consumption against AD. Larger studies with longer follow-up periods should be encouraged, addressing other potential bias and confounding sources, so hopefully opening new ways for diet-related prevention of dementia and AD.

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“…An EFSA scientific panel concluded there was sufficient evidence to establish a causal relationship between caffeine and an increase in endurance performance, endurance capacity, alertness and attention, and a reduction in the perceived exertion/effort during exercise (EFSA 2011a(EFSA , 2011b. Caffeine has also been linked to a lower risk of Parkinson's disease (Qi & Li 2014) and a slower rate of age-related cognitive decline (Vercambre et al 2013). Reviews of the beneficial effects of human caffeine consumption are available elsewhere (Glade 2010;Heckman et al 2010;Shen 2012;Cano-Marquina et al 2013).…”

Section: Introductionmentioning

confidence: 98%

Energy drink consumption and impact on caffeine risk

Thomson¹,

Campbell

Cressey³

et al. 2014

Food Additives & Contaminants: Part A

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The impact of caffeine from energy drinks occurs against a background exposure from naturally occurring caffeine (coffee, tea, cocoa and foods containing these ingredients) and caffeinated beverages (kola-type soft drinks). Background caffeine exposure, excluding energy drinks, was assessed for six New Zealand population groups aged 15 years and over (n = 4503) by combining concentration data for 53 caffeine-containing foods with consumption information from the 2008/09 New Zealand Adult Nutrition Survey (ANS). Caffeine exposure for those who consumed energy drinks (n = 138) was similarly assessed, with inclusion of energy drinks. Forty-seven energy drink products were identified on the New Zealand market in 2010. Product volumes ranged from 30 to 600 ml per unit, resulting in exposures of 10-300 mg caffeine per retail unit consumed. A small percentage, 3.1%, of New Zealanders reported consuming energy drinks, with most energy drink consumers (110/138) drinking one serving per 24 h. The maximum number of energy drinks consumed per 24 h was 14 (total caffeine of 390 mg). A high degree of brand loyalty was evident. Since only a minor proportion of New Zealanders reported consuming energy drinks, a greater number of New Zealanders exceeded a potentially adverse effect level (AEL) of 3 mg kg(-1) bw day(-1) for caffeine from caffeine-containing foods than from energy drinks. Energy drink consumption is not a risk at a population level because of the low prevalence of consumption. At an individual level, however, teenagers, adults (20-64 years) and females (16-44 years) were more likely to exceed the AEL by consuming energy drinks in combination with caffeine-containing foods.

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Caffeine and Cognitive Decline in Elderly Women at High Vascular Risk

Cited by 54 publications

References 42 publications

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

Energy drink consumption and impact on caffeine risk

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