Caffeine Affects Cardiovascular and Neuroendocrine Activation at Work and Home

Lane, James D.; Pieper, Carl F.; Phillips-Bute, Barbara; Bryant, John E.; Kuhn, Cynthia M.

doi:10.1097/00006842-200207000-00009

Cited by 26 publications

(22 citation statements)

References 48 publications

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“…On the positive side, Gx was not associated with any measurable changes in blood pressure or heart rate as previously reported following the administration of bitter orange extract, 8 although this contrasts with the effects of caffeine. 34 The treatment formulation, combining the effects of EGCG and caffeine to stimulate b1-adrenoreptor activity seems logical given the link between this and resting metabolic rate. 31 It remains to be seen if chronic administration of Gx is effective in stimulating greater loss of weight, particularly if combined with regular exercise.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males

et al. 2006

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Objective: This study examined the acute effects of ingesting a widely used commercial formula containing extracts of bitter orange, green tea and guarana (Gx) on the metabolic rate and substrate utilisation in overweight, adult males at rest (study 1) and during treadmill walking (study 2). Subjects: Two different groups of 10 sedentary males with more than 20% body fat participated in studies 1 and 2. Design: In each study, subjects participated in two experimental trials during which they were given two 500 mg capsules containing either Gx or a placebo (P) in a counterbalanced double-blind manner. Doses of the main active ingredients were 6 mg of synephrine, 150 mg caffeine and 150 mg catechin polyphenols. Measurements: In study 1, subjects completed 7 h supine rest with baseline measures taken during the first hour, with expired gases, blood pressure, heart rate and venous blood being collected every 30 min for the remaining 6 h following ingestion of Gx or P. In study 2, subjects exercised for 60 min at 60% heart rate reserve following ingestion of Gx or P 1 h previously. Venous blood samples were collected twice at rest and at 5,10,15,20,30, 40, 50 and 60 min, with expired gas measurements taken at 4, 9, 14, 19, 29, 39, 49 and 59 min. In both studies, venous blood was analysed for NEFA, glycerol, glucose and lactate concentrations, while expired gases were used to calculate ATP production from carbohydrate and NEFA, as well as the total substrate utilised. Results and conclusion: The results did not show any significant effect of Gx ingestion on total ATP utilisation during 6 h rest or during 60 min treadmill walking. Changes were observed in the relative contributions of CHO and NEFA oxidation to ATP production in both studies, such that there was an increase in ATP production from CHO and a decrease from NEFA. The increase in CHO oxidation was shown to be as high as 30% at rest.

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Section: Discussionmentioning

confidence: 99%

Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males

et al. 2006

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“…It may exaggerate sympathetic adrenalmedullary responses to the stressful events of normal daily life. Repeated daily blood pressure elevations and increases in stress reactivity caused by caffeine consumption could contribute to an increased risk of coronary heart disease in the adult population ( Lane, 2002 (Jee et al, 1999;Klag et al, 2003).…”

Section: A Sizeable Portion (146%) Of the Study Population Were Casementioning

confidence: 99%

Prevalence of hypertension in a University Community in South West Nigeria

Erhun¹,

Olayiwola²,

Agbani³

et al. 2006

African Journal of Biomedical Research

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A worksite study of hypertension prevalence was carried out in a university community in Southwestern Nigeria. Overall crude prevalence was 21% in the respondent population. About 16% of these were already on treatment with medicines. The study established no significant (p>0.05) relationship between coffee consumption and hypertension. Prevalence was 32% in subjects with over 3 children, while among subjects with eye problem, diabetics and those who took local kola nuts and it was 18.6%, 1.9% and 7.4%, respectively. There is need for increased awareness of the disease and other cardiovascular risk factors within the populace and to encourage the possession or provision of self-measurement blood pressure devices.

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“…Although, the gender gap was wide, substance abuse generally is commoner among males than females [57]. There is a bidirectional relationship between substance abuse and hypertension i. e. substance abuse particularly alcohol can cause hypertension while hypertension, on the other hand, can precipitate substance abuse due to frustration [65][66][67]. However, the true relationship still remains difficult to establish in this study.…”

Section: Discussionmentioning

confidence: 88%

Pattern and Prevalence of Psychiatric Comorbidity in Patients with Essential Hypertension in Port Harcourt, Nigeria

Kennedy¹

2016

AJPN

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Essential hypertension, a non communicable disease, is assuming an epidemic dimension, of the nature of a communicable condition. It, predominantly affects the physical, social and psychological well-being of the middle to elderly age group, with the former incidentally contributing over 50% of Nigeria workforce, hence interfering with the nation's economic well-being . Although few of such studies have been done in this environment, hypertensionhas been variously cited to be commonly associated with psychiatric comorbidity. The aim of this study, therefore, was to determine the pattern and prevalence of psychiatric co-morbidity among subjects with essential hypertension attending the out patient clinic of the University of Port Harcourt Teacing Hospital (UPTH). In this cross-sectional study, following ethical approval from the appropriate committee of the hospital and informed consent from the participants, 360 subjects making up the study group were recruited based on the study's inclusion exclusion criteria, after a Pilot Study (In addition, the hypertensives were screened for HIV infection and also investigated for other chronic medical illnesses). Subjects were further administered with the study's instruments including the socio-demorgraphic questionnaire, GHQ-12 and WHOCIDI. The data were analyzed using the SPSS version 20. Confidence interval was set at 95% while P -value of less than 0.05 was considered statistically significant. The study found a 64.4% (n=232) rate of psychiatric comorbidity among the hypertensive patients with depressive illness the highest with 73(29.4%). This was followed by GAD with 16.1%, sexual dysfunction 9.0%, mixed anxiety and depression 7.8%, substance abuse 2.3%, dysthymia 0.3%, while panic without agoraphobia and personality disorders 0.9% each. Severity of hypertension correlated positively with psychiatric comorbidity. The study found that psychiatric comorbidity among the hypertensive patient is common in UPTH. It therefore becomes imperative that the intervention measures for chronic disorders of these natures should include a well planned, elaborate and articulated neuropsychiatric evaluation for an effective and holistic management of these patients.

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Caffeine Affects Cardiovascular and Neuroendocrine Activation at Work and Home

Cited by 26 publications

References 48 publications

Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males

Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males

Prevalence of hypertension in a University Community in South West Nigeria

Pattern and Prevalence of Psychiatric Comorbidity in Patients with Essential Hypertension in Port Harcourt, Nigeria

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