Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men

Moisey, Lesley L.; Kacker, Sita; Bickerton, Andrea C; Robinson, Lindsay E.; Graham, Terry E.

doi:10.1093/ajcn/87.5.1254

Cited by 105 publications

(92 citation statements)

References 36 publications

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“…Although speculative, plasma glucose may remain unchanged in fasting conditions, despite decreases in insulin production, if peripheral insulin sensitivity increases and/or hepatic glucose output decreases. A previous study showed in 10 patients that CC impairs postprandial glucose and insulin sensitivity compared with DC (Moisey et al, 2008). On the contrary, CC impairs insulin secretion in the fasting state.…”

Section: Discussionmentioning

confidence: 92%

“…Information with regard to the metabolic and cardiovascular effects of coffee has been conflicting (Greenberg et al, 2006;Bonita et al, 2007;Klatsky et al, 2008). Short-term studies on the acute effects of coffee intake have generally reported detrimental cardiovascular and metabolic influences (Mahmud and Feely, 2001;Moisey et al, 2008;Riksen et al, 2009). In some instances, epidemiological studies have indicated that regular consumption of coffee is associated with lower risk of cardiovascular disease and type 2 diabetes (Silletta et al, 2007;Larsson et al, 2008;Odegaard et al, 2008;van Woundenbergh et al, 2008;Van Dam and Hu, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Acute effects of coffee on endothelial function in healthy subjects

et al. 2010

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Background/Objectives: Coffee is the most widely consumed beverage in the world, but its effect on the cardiovascular system has not been fully understood. Coffee contains caffeine and antioxidants, which may influence endothelial function, both of which have not yet been investigated. The objective of this study was to investigate the acute effects of coffee on endothelial function measured by brachial artery flow-mediated dilation (FMD). Subjects/Methods: A total of 20 (10 males and 10 females) healthy non-obese subjects underwent a double-blind, crossover study. Subjects ingested one cup of caffeinated (CC) and one cup of decaffeinated (DC) Italian espresso coffee in random order at 5-to 7-day intervals. Results: Following CC ingestion, FMD decreased progressively and significantly (mean±s.e.m.: 0 min, 7.7±0.6; 30 min, 6.3 ± 0.7; 60 min, 6.0 ± 0.8%; ANOVA (analysis of variance), Po0.05), but it did not significantly increase after DC ingestion (0 min, 6.9±0.6; 30 min, 8.1±0.9; 60 min, 8.5±0.9%; P ¼ 0.115). Similarly, CC significantly increased both systolic and diastolic blood pressure; this effect was not observed after DC ingestion. Blood glucose concentrations remained unchanged after ingestion of both CC and DC, but insulin (0 min, 15.8±0.9; 60 min, 15.0±0.8 mU/ml; Po0.05) and C-peptide (0 min, 1.25 ± 0.09; 60 min, 1.18 ± 0.09 ng/ml; Po0.01) blood concentrations decreased significantly only after CC ingestion. Conclusions: CC acutely induced unfavorable cardiovascular effects, especially on endothelial function. In the fasting state, insulin secretion is also likely reduced after CC ingestion. Future studies will determine whether CC has detrimental clinically relevant effects, especially in unhealthy subjects.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Acute effects of coffee on endothelial function in healthy subjects

et al. 2010

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“…In the past few years, several epidemiological studies point toward a protective role for coffee in the development of type 2 diabetes (Van Dam and Feskens 2002;Van Dam et al 2006), contrasting with reports that caffeine can lower insulin sensitivity when administered acutely (Keijzers et al 2002;Moisey et al 2008). The primary mechanism proposed for the protective role of caffeine in the development of type 2 diabetes was weight loss attributed to increased thermogenesis, lipolysis, and fat oxidation induced by this xanthine (Lopez-Garcia et al 2006;Van Dam et al 2006;Zheng et al 2004;Jeukendrup and Randell 2011) via sympathetic nervous system (SNS) activation (Dulloo et al 1992;Graham et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

Ribeiro¹,

Sacramento²,

Conde³

2012

AGE

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The role of caffeine consumption on insulin action is still under debate. The hypothesis that chronic caffeine intake reverses aging-induced insulin resistance in the rat was tested in this work. The mechanism by which caffeine restores insulin sensitivity was also investigated. Six groups of rats were used: 3 months old (3 M), 3 months old caffeine-treated (3MCaf), 12 months old (12 M), 12 months old caffeine-treated (12MCaf), 24 months old (24 M), and 24 months old caffeinetreated (24MCaf). Caffeine was administered in drinking water (1 g/l) during 15 days. Insulin sensitivity was assessed by means of the insulin tolerance test. Blood pressure, body weight, visceral and total fat, fasting glycemia and insulinemia, plasma nonesterified fatty acids (NEFA), total antioxidant capacity (TAC), cortisol, nitric oxide, and catecholamines were monitored. Skeletal muscle Glut4 and 5′-AMP activated protein kinase (AMPK) protein expression and activity were also assessed. Aged rats exhibited diminished insulin sensitivity accompanied by hyperinsulinemia and normoglycemia, increased visceral and total fat, decreased TAC and plasma catecholamines, and also decreased skeletal muscle Glut4 and AMPK protein expression. Chronic caffeine intake restored insulin sensitivity and regularized circulating insulin and NEFA in both aging models. Caffeine neither modified skeletal muscle AMPK expression nor activity in aged rats; however, it decreased visceral and total fat in 12 M rats and it restored skeletal muscle Glut4 expression to control values in 24 M rats. We concluded that chronic caffeine intake reverses aging-induced insulin resistance in rats by decreasing NEFA production and also by increasing Glut4 expression in skeletal muscle.

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“…The acute effect of coffee may be different if consumed within a meal or before the meal, and if it is decaffeinated or caffeinated coffee. It has been shown that caffeinated coffee elicited acute insulin insensitivity when ingested around one hour before a carbohydrate meal compared to decaffeinated coffee (Moisey et al, 2008). Additionally, co-ingestion of caffeinated coffee with a high carbohydrate meal increased the blood glucose response, without modifying postprandial insulin response.…”

Section: Impact Of Phytochemicals On Blood Glucose Regulationmentioning

confidence: 99%

Impact of Diet Composition on Blood Glucose Regulation

Russell

Baka

Björck

et al. 2013

Critical Reviews in Food Science and Nutrition

152

107

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Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary components on blood glucose levels. Included are the major macronutrients; carbohydrate, protein and fat, micronutrient vitamins and minerals, nonnutrient phytochemicals and additional foods including low-calorie sweeteners, vinegar, and alcohol. Based on the evidence presented in this review, it is clear that dietary components have significant and clinically relevant effects on blood glucose modulation. An integrated approach that includes reducing excess body weight, increased physical activity along with a dietary regime to regulate blood glucose levels will not only be advantages in T2DM management, but will benefit the health of the population and limit the increasing worldwide incidence of T2DM.

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Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men

Abstract: The ingestion of CC with either a high or low GI meal significantly impairs acute blood glucose management and insulin sensitivity compared with ingestion of DC. Future investigations are warranted to determine whether CC is a risk factor for insulin resistance.

Cited by 105 publications

References 36 publications

Acute effects of coffee on endothelial function in healthy subjects

Acute effects of coffee on endothelial function in healthy subjects

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

Impact of Diet Composition on Blood Glucose Regulation

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