Caffeic acid protects human trophoblast HTR-8/SVneo cells from H2O2-induced oxidative stress and genotoxicity

Kostic, S.; Vilotić, Aleksandra; Pirković, Andrea; Dekanski, Dragana; Borozan, Sunčica; Nacka-Aleksić, Mirjana; Vrzić-Petronijević, Svetlana; Krivokuća, Milica Jovanović

doi:10.1016/j.fct.2022.112993

Cited by 14 publications

(6 citation statements)

References 76 publications

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“…However, CA supplementation has been shown to improve the levels of these antioxidant enzymes, which is in agreement with the findings of Wan et al 8 A recent study also found that CA can protect HTR-8/SVneo cells from oxidative stress and genotoxicity induced by H 2 O 2 . 25 The obtained data revealed their promising antioxidant behaviour. In terms of mechanism, it has been shown that CA alleviates oxidative stress by regulating the Nrf2/HO-1 pathway, thus preventing colitis.…”

Section: Discussionmentioning

confidence: 83%

Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

et al. 2023

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Section: Discussionmentioning

confidence: 83%

Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

et al. 2023

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“…In vitro studies on human cells showed that CA increased antioxidant capacity in endometrial cells [39] and was also efficient in inhibiting the oxidative damage in human umbilical vein endothelial cells (HUVECs) [40]. The favorable effects of CA in trophoblast cells in both normal conditions and under increased oxidative stress was confirmed in the most recent study [41]. In that study, the investigated concentrations of CA were neither cytotoxic nor genotoxic.…”

Section: The Role Of Dietary Polyphenols In Early-pregnancy Eventsmentioning

confidence: 83%

“…Caffeic acid helped in the attenuation of DNA damage, protein and lipid peroxidation, and in the significant elevation of GSH concentration in human trophoblast HTR-8/SVneo cells following exposure to strong oxidant. All of these results indicate potential beneficial effects of food rich in CA for pregnancy disorders related to increased oxidative stress [41]. Besides these experiments, CA was also used for surface modification of zirconium dioxide nanoparticles (ZrO2 NPs) to attenuate NPs' toxicity, and the results indicated that hybrid NPs did not affect viability of HTR-8/SVneo cells [42].…”

Section: The Role Of Dietary Polyphenols In Early-pregnancy Eventsmentioning

confidence: 91%

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

et al. 2022

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Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.

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“…In our study, the results of non-toxic OM and OM-AgNPs on cells may be associated with the size and stability of the particles during characterization. In addition to these studies, some other pure compounds protected healthy cells from undesired effects of H 2 O 2 [42,43,44]. Plant extracts containing polyphenols have a protective effect on endothelial cells by inhibiting free radicals, DNA synthesis, regulating the cell cycle and increasing their viability [45].…”

Section: Cytotoxicitymentioning

confidence: 99%

Silver nanoparticles loaded with Origanum majorana leaves extracts attenuates the vascular endothelial cell senescence by inhibiting inflammation and oxidative stress

Alotaibi,

Salamatullah,

Pandurangan

et al. 2024

Preprint

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Background Aging is thought to be associated with vascular endothelial cell dysfunction or senescence upon oxidative stress. Hence, the need of therapeutic agent to protect cells from oxidative stress intracellularly without functional loss also with high bioavailability is the biggest challenge. Methods In the present study, we used AgNO3 serving as reducing and capping agents to synthesis silver nanoparticles (Ag-NPs) using commonly used aromatic plant (Mentha piperita, Mentha longifolia and Origanum majorana) extracts. The identification of phytochemical was carried out by Gas chromatography-Mass spectrometry (GC-MS). The analytical techniques including UV–vis absorption spectroscopy confirmed the formation of silver nanoparticles. FT-IR, identified the capping and reduction processes of functional groups in the Ag-NPs. SEM (Scanning electron microscopy), confirmed the uniform shape and size of the synthesized Ag-NPs. Results We found Origanum majorana (OM) effectively reduced with Ag-NPs and exhibited better nanoparticle-formation than the rest of the samples. Further, 2 mg/mL concentration of OM-Ag-NPs, the PDI results yielded evidence of good stability and dispersion. In addition, both the extracts and their corresponding Ag-NPs utilized to assesss their protective and beneficial effects on oxidative stress-induced HUVECs, which include nuclear damage, morphological changes associated with apoptosis, and alterations in gene expression levels. OM and its nanoparticles treated to HUVECs for 48 h increased vascular cells proliferation confirmed in MTT assay, observed with normal morphology, and mRNA expression levels confirmed the decrease of lipid peroxides (LPO), increasing antioxidants (SOD, GSK-3β, and GPx), increasing oxidative phosphorylating (CYP1a), and decreasing Tumor suppression (p53). Conclusion OM and its nanoparticles are considered to be beneficial for the prevention of H2O2 induced oxidative stress, it may be a promising preventive agent for endothelial cell senescence and aging.

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Caffeic acid protects human trophoblast HTR-8/SVneo cells from H2O2-induced oxidative stress and genotoxicity

Cited by 14 publications

References 76 publications

Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

Silver nanoparticles loaded with Origanum majorana leaves extracts attenuates the vascular endothelial cell senescence by inhibiting inflammation and oxidative stress

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