Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities

Salau, Veronica F.; Erukainure, Ochuko L.; Islam, Shahidul

doi:10.1007/s12011-020-02227-3

Cited by 30 publications

(24 citation statements)

References 59 publications

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“…This is further evidenced by the elevated cardiac MDA level ( Figure 1D ) which indicates a peroxidative effect on the cardiac lipids following the induction of oxidative cardiac injury. These altered activities and levels correspond with previous reports on the occurrence of oxidative stress after induction of oxidative injury in isolated hearts ( Erukainure et al, 2020a ; Salau et al, 2020b ). The onset of oxidative stress can be attributed to iron-catalyzed Fenton’s and Haber-Weiss reactions following the incubation of heart tissues with Fe 2+ .…”

Section: Discussionsupporting

confidence: 91%

“…acetylcholinesterase activities (Agunloye et al, 2019;Salau et al, 2020b). Purinergic enzyme activities have been reported to play an important role in the normal physiological activities of the heart.…”

Section: Discussionmentioning

confidence: 99%

“…A 100 µl of the cardiac tissue supernatant was incubated with 0.1 mM FeSO 4 (pro-oxidant) and different concentrations (30, 60, 120 and 240 μg/ml) of the DCM extract of T. oblongata at 37°C for 30 min according to previously published methods ( Erukainure et al, 2020a ; Salau et al, 2020b ). Reaction samples without the extract served as the negative control (untreated), while reaction sample without the pro-oxidant and extract served as the normal control.…”

Section: Methodsmentioning

confidence: 99%

“…Fatty acids (FAs) have been reported as a major energy source for the heart, as they are estimated to meet over 70% of the heart’s energy needs ( Drosatos and Schulze, 2013 ). Alteration in cardiac FAs and their metabolism leading to lipotoxicity has been implicated among the pathomechanism of cardiovascular dysfunctions ( Erukainure et al, 2020b ; Salau et al, 2020b ). Exacerbated activities of cardiac lipase and angiotensin-converting enzyme (ACE), as well as altered cardiac supply of triglycerides from the liver and accumulation of cholesterol in the heart are major contributing factors of lipotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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Turbina oblongata Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions

et al. 2021

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Cardiotoxicity leading to cardiovascular dysfunction and ultimately cardiac failure remains a major global health issue irrespective of race, age and country. Several factors including lipotoxicity, oxidative imbalance, exacerbated angiotensin-converting enzyme (ACE) activity and altered bioenergetics have been implicated in the pathophysiology of cardiovascular diseases. Turbina oblongata (E. Mey. ex Choisy) A. Meeuse is among the medicinal plants commonly used traditionally in the treatment and management of various ailments including cardiovascular dysfunctions in South Africa. In the present study, T. oblongata was investigated for its cardioprotective mechanism on oxidative-mediated cardiotoxicity by determining its effect on redox imbalance, purinergic and cholinergic dysfunction, and ACE activity as well as lipid dysmetabolism and pathways in iron-induced oxidative cardiac injury. Oxidative injury was induced ex vivo in freshly isolated heart by incubating with 0.1 mM FeSO4. Treatment was done by co-incubating with T. oblongata extract or gallic acid which served as the standard antioxidant. Induction of oxidative cardiac injury led to significant depleted levels of glutathione, triglyceride, HDL-cholesterol, superoxide, catalase and ENTPDase activities, with concomitant elevated levels of malondialdehyde, cholesterol, LDL-cholesterol, ACE, acetylcholinesterase, ATPase and lipase activities. These levels and activities were significantly reversed following treatment with T. oblongata. Induction of oxidative injury also caused alterations in lipid metabolites, with concomitant activation of beta oxidation of very long chain fatty acids, plasmalogen synthesis and mitochondrial beta-oxidation of long chain saturated fatty acids pathways. Some of the altered metabolites were restored following treatment with T. oblongata, with concomitant inactivation of beta oxidation of very long chain fatty acid pathway. These results indicate the cardioprotective effect of T. oblongata against oxidative-mediated cardiotoxicity. This is evidenced by its ability to mitigate lipotoxicity and modulate dysregulated cardiometabolic activities as portrayed by its antioxidative activity and suppressive effects on ACE, acetylcholinesterase and lipase activities, while modulating cardiac lipid dysmetabolism.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Turbina oblongata Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions

et al. 2021

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“…2015). This can be attributed to the reaction between NO and excess superoxide (O 2 •−) to yield peroxynitrite (ONOO − ) which is a potent nitroxative agent with pro‐inflammatory activities (Salau et al, 2019, Salau, Erukainure, & Islam, 2020). The increased NO level following oxidative brain injury induction (Figure 4) may indicate a reaction between NO and O 2 •− (arising from suppressed SOD activity) to yield ONOO − , thus insinuating a pro‐inflammatory activity in brain tissues that were untreated.…”

Section: Discussionmentioning

confidence: 99%

Modulatory effect of ursolic acid on neurodegenerative activities in oxidative brain injury: Anex vivostudy

et al. 2020

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Caffeic acid and its derivative caffeic acid phenethyl ester as potential therapeutic compounds for cardiovascular diseases: A systematic review

Nasimi Shad,

Akhlaghipour,

Babazadeh Baghan

et al. 2024

Archiv der Pharmazie

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Cardiovascular diseases (CVDs) contribute to major public health issues. Some studies have found that caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) may effectively prevent or treat CVDs. However, there is a major need to sum up our current understanding of the possible beneficial or detrimental effects of CA and CAPE on CVDs and related mechanisms. Therefore, this study aimed to summarize the data on this topic. A methodical search was carried out on key databases, including Pubmed, Google Scholar, Scopus, and Web of Science, from the beginning to June 2024. Studies were then assessed for eligibility based on inclusion and exclusion criteria. Treatment with CA and CAPE significantly and positively affected cardiovascular health in various aspects, including atherosclerotic diseases, myocardial infarction, hypertension, cardiac arrhythmias, and hypercoagulation state. Several mechanisms were proposed to mediate these effects, including transcription factors and signaling pathways associated with antioxidant, cytostatic, and anti‐inflammatory processes. CA and CAPE were found to have several beneficial effects via multiple mechanisms during the prevention and treatment of various CVDs. However, these promising effects were only reported through in vitro and animal studies, which reinforces the need for further evaluation of these effects via human clinical investigations.

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Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities

Cited by 30 publications

References 59 publications

Turbina oblongata Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions

Turbina oblongata Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions

Modulatory effect of ursolic acid on neurodegenerative activities in oxidative brain injury: Anex vivostudy

Caffeic acid and its derivative caffeic acid phenethyl ester as potential therapeutic compounds for cardiovascular diseases: A systematic review

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