Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model

Abstract

The present study was conducted to investigate whether caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has a protective effect on amphotericin B induced nephrotoxicity in rat models. Male Wistar-Albino rats were randomly divided into four groups: (I) control group (n = 10), (II) CAPE group (n = 9) which received 10 μmol/kg CAPE intraperitoneally (i.p.), (III) amphotericin B group (n = 7) which received one dose of 50 mg/kg amphotericin B, and (IV) amphotericin B plus CAPE group (n = 7) which received 10 μmol/kg CAPE i.p. and one dose of 50 mg/kg amphotericin B. The left kidney was evaluated histopathologically for nephrotoxicity. Levels of malondialdehyde (MDA), nitric oxide (NO), enzyme activities including catalase (CAT), and superoxide dismutase (SOD) were measured in the right kidney. Histopathological damage was prominent in the amphotericin B group compared to controls, and the severity of damage was lowered by CAPE administration. The activity of SOD, MDA, and NO levels increased and catalase activity decreased in the amphotericin B group compared to the control group (P = 0.0001, P = 0.003, P = 0.0001, and P = 0.0001, resp.). Amphotericin B plus CAPE treatment caused a significant decrease in MDA, NO levels, and SOD activity (P = 0.04, P = 0.02, and P = 0.0001, resp.) and caused an increase in CAT activity compared with amphotericin B treatment alone (P = 0.005). CAPE treatment seems to be an effective adjuvant agent for the prevention of amphotericin B nephrotoxicity in rat models.

Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis

“…The doses of cinnamic acid derivatives used in the previous studies ranged from 2 mg/kg to 250 mg/kg, and studies reported relatively low doses as 5.5 to 10 mg/kg. [22][23][24]…”

The Effect of Cape on Steroid Induced Osteonecrosis of the Femoral Head in Rat Model

“…CAPE is a natural bioactive compound which has various pharmacological and biological activities such as antioxidant, anticancer, anti-inflammatory, antiviral, anti-metastatic, immunomodulatory, antiplatelet and antilipidemic eff ect 21,18,19,15,16,20,39) An animal study revealed that high serum levels of low-density lipoprotein cholesterol (LDL-C) was significantly associated with the incidence of ONFH 40) . In another study total serum cholesterol and triglyceride levels were found signifi cantly higher in animals with ONFH compared to controls 35) .…”

“…Phenolic acid, phenolic acid esters, amino acids, steroids, flavonoids are some of them 16,17) . The antioxidant, anticoagulant, antilipidemic, anticancer, anti-infl ammatory, antiviral, antimetastatic, immunomodulatory eff ects of CAPE are well known 18,19,15,16,20,21) .…”

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies

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