Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats

Silva, Roberto de Barros; Santos, Neife Aparecida Guinaim dos; Martins, Nádia Maria; Ferreira, Danilio Alvear Sampaio; Barbosa, Fernando; Souza, Vanessa Aparecida Feijó de; Kinoshita, Ângela; Baffa, Oswaldo; Del‐Bel, Elaine; Santos, Antônio Cardozo dos

doi:10.1016/j.neuroscience.2012.12.041

Cited by 66 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most frequent finding is that this effect is negligible in normal somatic cells (cardiomyocytes, neurons, and hepatocytes), but becomes beneficial in the cells challenged by toxic stimuli where oxidative phosphorylation is compromised [16, 35, 36]. In contrast, in various types of tumor cells, propolis extract or its constituents inhibit oxidative phosphorylation and trigger release of cytochrome c and subsequent apoptosis [15, 17].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Czech Propolis on Sperm Mitochondrial Function

Čedíková

Miklikova

Stachova

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Propolis is a natural product that honeybees collect from various plants. It is known for its beneficial pharmacological effects. The aim of our study was to evaluate the impact of propolis on human sperm motility, mitochondrial respiratory activity, and membrane potential. Semen samples from 10 normozoospermic donors were processed according to the World Health Organization criteria. Propolis effects on the sperm motility and mitochondrial activity parameters were tested in the fresh ejaculate and purified spermatozoa. Propolis preserved progressive motility of spermatozoa in the native semen samples. Oxygen consumption determined in purified permeabilized spermatozoa by high-resolution respirometry in the presence of adenosine diphosphate and substrates of complex I and complex II (state OXPHOSI+II) was significantly increased in the propolis-treated samples. Propolis also increased uncoupled respiration in the presence of rotenone (state ETSII) and complex IV activity, but it did not influence state LEAK induced by oligomycin. Mitochondrial membrane potential was not affected by propolis. This study demonstrates that propolis maintains sperm motility in the native ejaculates and increases activities of mitochondrial respiratory complexes II and IV without affecting mitochondrial membrane potential. The data suggest that propolis improves the total mitochondrial respiratory efficiency in the human spermatozoa in vitro thereby having potential to improve sperm motility.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of the Czech Propolis on Sperm Mitochondrial Function

Čedíková

Miklikova

Stachova

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The participation of programmed cell death in the 6-OHDA-caused neurodegeneration was also supported by the results of caspase-3 colorimetric assay. Oxidative stress initiates mitochondrial caspase cascade in 6-OHDA-induced apoptosis, which triggers the apoptosome formation, that in turn activates caspase-9 and the main effector caspase-3 (Hanrott et al, 2006;Barros Silva et al, 2013). As shown in Fig.…”

Section: 3mentioning

confidence: 94%

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

Morroni¹,

Sita²,

Tarozzi³

et al. 2014

Brain Research

View full text Add to dashboard Cite

“…They also reported that CA inhibits lipid peroxidation, which occurs due to oxidative stress in the brain, compared with the Aβ 25–35 -injected control group [48]. In an animal model of Parkinson’s disease generated by injection of 6-hydroxydopamine into the rat brain, CAPE prevents dopaminergic neuronal cell loss [49]. Further, Liang et al reported that CA protects cerebral damage against ischemia-reperfusion injury in rats [50].…”

Section: Neuroprotection By Coffee Polyphenolsmentioning

confidence: 99%

Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival

Mikami

Kakizawa

Yamazawa

2016

IJMS

View full text Add to dashboard Cite

Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches.

show abstract

Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats

Cited by 66 publications

References 42 publications

Effects of the Czech Propolis on Sperm Mitochondrial Function

Effects of the Czech Propolis on Sperm Mitochondrial Function

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival

Contact Info

Product

Resources

About