Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity in mice: Role of miR-182-5p/TLR4 axis

Hao, Rili; Ge, Junlin; Ren, Yuan; Song, Xubin; Jiang, Yang; Sun‐Waterhouse, Dongxiao; Li, Feng

doi:10.1016/j.ecoenv.2020.111578

Cited by 27 publications

(28 citation statements)

References 37 publications

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“…It was confirmed that Cd exposure resulted in apparent liver damage, indicating that Cd-induced liver injury model in vivo was well-established. Similar liver injury phenomena were presented in other related studies ( 2 , 23 , 37 – 39 ). Simultaneously, Se-SPP possessed significant suppressive effect on cadmium-induced hepatic injury in mice, and the effect was superior than that of inorganic selenium.…”

Section: Discussionsupporting

confidence: 89%

“…Simultaneously, Se-SPP possessed significant suppressive effect on cadmium-induced hepatic injury in mice, and the effect was superior than that of inorganic selenium. Rosa persica hydroalcoholic extract, caffeic acid phenethyl ester, and chlorogenic acid have been used in associated research studies and exhibited similar results ( 23 , 37 , 39 ).…”

Section: Discussionmentioning

confidence: 91%

“…Blood samples were collected by extirpating the eyeballs and centrifuged at 3,500 × g for 15 min, 4 °C [Universal 320R, Hettich Zentrifugen, Germany) to obtain serum, of which the levels of hepatic function biomarkers (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (T-Bil), and lactate dehydrogenase (LDH)] were measured using commercial kits (Mindray Bio-Medical Electronics Co., Ltd, Shenzhen, China) according to manual instructions ( 23 ).…”

Section: Methodsmentioning

confidence: 99%

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Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Zhou

Long

et al. 2022

Front. Nutr.

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Selenium-containing polysaccharide from Spirulina platensis (Se-SPP) has been demonstrated to help in inhibiting cadmium-induced injury in mice, but the underlying mechanism has not been determined. This study aimed to investigate the beneficial effects of Se-SPP on alleviating Cd-induced toxicity in mice by targeting liver inflammatory and gut microbiota. Se-SPP supplementation for 28 days in Cd-induced toxic mice significantly mitigated liver pathological damage and inflammation, which was correlated to the upregulation of antioxidant enzyme activity. Furthermore, Se-SPP effectively restored Cd-induced disruption of the intestinal barrier compared to model group, as indicated by the depletion of Muribaculaceae and the enrichment of Ruminococcaceae. Spearman's correlation analysis revealed that the Se-SPP-altered microbes were highly correlated with inflammation-related indexes in Cd-induced toxic mice. Noteworthily, the modulation of Se-SPP on the Ruminococcaceae population contributed to the improvement of Cd-induced inflammation-related diseases by downregulating the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the liver. These findings suggested that Se-SPP may act as prebiotics for ameliorating Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota, and target-specific microbiota of Cd-induced inflammation-related diseases deserve further attention.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Zhou

Long

et al. 2022

Front. Nutr.

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“…Cadmium, a heavy metal widely exists in the environment, has been linked to a variety of health problems, including the damages to liver, kidney and brain 5,29 . Ferroptosis is a non‐apoptotic form of cell death, which has implications in neurologic diseases 30 .…”

Section: Discussionmentioning

confidence: 99%

Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells

Hao

Song

et al. 2021

Environmental Toxicology

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Cadmium (Cd) is a potent neurotoxic metal present in the environment and food. In this study, CdCl2 (2 or 4 μM) induced cytotoxicity and neurotoxicity in PC12 cells, causing decreases in cell viability and NEP protein expression and increase in p‐tau protein expression. For the first time, CdCl2‐initiated injury was found to result from the induction of not only apoptosis but also ferroptosis, as evidenced by the increased iron content, ROS production, and mitochondrial membrane potential along with changes in the expressions of iron death‐related genes (FTH1, GPX4, ASCL4, PTGS2, and NOX1) and levels of caspase9, Bax, and Bcl‐2 proteins. The molecular mechanisms leading to apoptosis and ferroptosis at least included the participation of the miR‐34a‐5p/Sirt1 axis, in which miR‐34a‐5p promoted CdCl2‐induced neurotoxicity through targeting Sirt1. Knocking out miR‐34a‐5p attenuated CdCl2‐induced damage of PC12 cells, cytotoxicity and neurotoxicity. This research provides the underlying molecular mechanisms of CdCl2‐induced damage and asserts the role of miRNAs as critical regulators.

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“…Very recently, Hao et al [ 87 ] explored the potential protective effect of CAPE on the cadmium-induced liver damage of 40 male mice that were treated daily with 10 μmol CAPE/kg body weight, gavage for four weeks. The authors concluded that CAPE administration significantly reduced cadmium level and improved liver tissue histopathology reporting for the first time a CAPE’s protection against CdCl 2 -induced hepatotoxicity.…”

Section: Biochemical and Health Properties Of The Examined Phenolic Acidsmentioning

confidence: 99%

A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections)

Kiokias

Oreopoulou

2021

Molecules

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Phenolic acids comprise a class of phytochemical compounds that can be extracted from various plant sources and are well known for their antioxidant and anti-inflammatory properties. A few of the most common naturally occurring phenolic acids (i.e., caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) have been identified as ingredients of edible botanicals (thyme, oregano, rosemary, sage, mint, etc.). Over the last decade, clinical research has focused on a number of in vitro (in human cells) and in vivo (animal) studies aimed at exploring the health protective effects of phenolic acids against the most severe human diseases. In this review paper, the authors first report on the main structural features of phenolic acids, their most important natural sources and their extraction techniques. Subsequently, the main target of this analysis is to provide an overview of the most recent clinical studies on phenolic acids that investigate their health effects against a range of severe pathologic conditions (e.g., cancer, cardiovascular diseases, hepatotoxicity, neurotoxicity, and viral infections—including coronaviruses-based ones).

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Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity in mice: Role of miR-182-5p/TLR4 axis

Cited by 27 publications

References 37 publications

Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells

A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections)

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