Caffeic Acid Phenethyl Ester (CAPE) May be a Promising Adjuvant Treatment in Gastric Cancer

Ribeiro, Ulysses; Safatle‐Ribeiro, Adriana Vaz

doi:10.1097/mcg.0b013e31806b5938

Cited by 10 publications

(4 citation statements)

References 32 publications

(12 reference statements)

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“…CAPE modulates NF-κB, it inhibits NF-κB binding activity and decreases the expression of NF-κB1 (p50) and RelA (p65) [21, 22, 32, 33]. We show here that CAPE inhibits NF-κB activity in MDA-231 cells (Figure 6a).…”

Section: Resultsmentioning

confidence: 60%

“…There are several studies reporting the in vitro and in vivo inhibitory effects of CAPE in multiple cancer models, such as colon cancer [27], lung cancer [28], melanoma [29], glioma [30], pancreatic cancer [31], gastric cancer [32], cholangiocarcinoma [33], hepatocellular carcinoma [34], and our data in breast cancer [35–39]. The role of CAPE as an inhibitor of angiogenesis, tumor metastasis and invasion has been demonstrated in several models of angiogenesis, both in vitro [40] and in vivo in colon cancer cells [41].…”

Section: Introductionmentioning

confidence: 99%

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Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

et al. 2011

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Breast cancer (BC) patients use alternative and natural remedies more than patients with other malignancies. Specifically, 63%–83% use at least one type of alternative medicine and 25%–63% use herbals and vitamins. Propolis is a naturopathic honeybee product, and CAPE (caffeic acid phenethyl ester), is a major medicinal component of propolis. CAPE, in a concentration dependent fashion, inhibits MCF-7 (hormone receptor positive, HR+) and MDA-231 (a model of triple-negative BC (TNBC) tumor growth, both in vitro and in vivo without much effect on normal mammary cells and strongly influences gene and protein expression. It induces cell cycle arrest, apoptosis and reduces expression of growth and transcription factors, including NF-κB. Notably, CAPE down-regulates mdr-1 gene, considered responsible for the resistance of cancer cells to chemotherapeutic agents. Further, CAPE dose-dependently suppresses VEGF formation by MDA-231 cells and formation of capillary-like tubes by endothelial cells, implicating inhibitory effects on angiogenesis. In conclusion, our results strongly suggest that CAPE inhibits MDA-231 and MCF-7 human breast cancer growth via its apoptotic effects, and modulation of NF-κB, the cell cycle, and angiogenesis.

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Section: Resultsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

et al. 2011

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“…Recent studies indicated that caffeic acid phenethyl ester (CAPE), a CA derivative naturally isolated from honeybee propolis, also exerts its beneficial effects through antioxidant and anti-inflammatory activities [29], [30]. Furthermore, it has been demonstrated that CAPE inhibits the proliferation of cancer cells and act as a potential anti-cancer agent [31], [32]. However, there is no report of the inhibitory effects of CA derivatives on the AMPK pathway and/or FASN expression during the progression of CRC.…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways

et al. 2014

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BackgroundThe aberrant regulation of phosphatidylinositide 3-kinases (PI3-K)/Akt, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (m-TOR) signaling pathways in cancer has prompted significant interest in the suppression of these pathways to treat cancer. Caffeic acid (CA) has been reported to possess important anti-inflammatory actions. However, the molecular mechanisms by which CA derivatives including caffeic acid phenethyl ester (CAPE) and caffeic acid phenylpropyl ester (CAPPE), exert inhibitory effects on the proliferation of human colorectal cancer (CRC) cells have yet to be elucidated.Methodology/Principal FindingsCAPE and CAPPE were evaluated for their ability to modulate these signaling pathways and suppress the proliferation of CRC cells both in vitro and in vivo. Anti-cancer effects of these CA derivatives were measured by using proliferation assays, cell cycle analysis, western blotting assay, reporter gene assay and immunohistochemical (IHC) staining assays both in vitro and in vivo. This study demonstrates that CAPE and CAPPE exhibit a dose-dependent inhibition of proliferation and survival of CRC cells through the induction of G0/G1 cell cycle arrest and augmentation of apoptotic pathways. Consumption of CAPE and CAPPE significantly inhibited the growth of colorectal tumors in a mouse xenograft model. The mechanisms of action included a modulation of PI3-K/Akt, AMPK and m-TOR signaling cascades both in vitro and in vivo. In conclusion, the results demonstrate novel anti-cancer mechanisms of CA derivatives against the growth of human CRC cells.ConclusionsCA derivatives are potent anti-cancer agents that augment AMPK activation and promote apoptosis in human CRC cells. The structure of CA derivatives can be used for the rational design of novel inhibitors that target human CRC cells.

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“…In addition, in vitro studies showed that CAPE inhibits tumor growth and the capacity for invasion. (Ribeiro & Safatle-Ribeiro, 2007).…”

Section: Gastric Cancermentioning

confidence: 99%

Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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Hydroxycinnamic acid compounds are an important source of antioxidants due to their ubiquitous occurrence in the plant kingdom and their characteristic activities. Due to their antioxidant activity, several researchers have attributed a probable role of these compounds in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular diseases. Recent evidence suggests that these compounds may also act by other mechanisms in addition to the antioxidant capacity as modulating the activity of some specific enzymes and inhibit cell proliferation. This paper is a comprehensive review of the effects of hydroxycinnamic acids on cancer. The review encompasses the occurrence and bioavailability of these compounds evidences for their effects on cancer and the various mechanisms by which may exert their effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis; effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.

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Caffeic Acid Phenethyl Ester (CAPE) May be a Promising Adjuvant Treatment in Gastric Cancer

Cited by 10 publications

References 32 publications

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways

Anticancer Properties of Hydroxycinnamic Acids -A Review

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