Caffeic acid phenethyl ester (CAPE) as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

Abstract

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).

Adverse effects of nicotine on endometrium receptivity markers: and protective effect of caffeic acid phenyl ester

“…Propolis is one of the bee products which is rich in famous polyphenols such as CAPE. This compound, as a potent antioxidant, is protective against the harmful oxygen free radical molecules, methotrexate and pesticides on the reproductive system [28]. It is a potent inhibitor of nuclear factor (NFKB), an anti-cancer, anti-in ammatory, immune modulator and reducer of blood pressure [29,30].…”

“…Endometrial angiogenesis is regulated by the progesterone type B receptor (PR-B) [26,27]. On the other hand, (CAPE), as a potent antioxidant, has protective effects against the oxygen free radical molecules, methotrexate and pesticides on reproductive system [28]. It is a nuclear factor (NFKB) inhibitor, anti-cancer, anti-in ammatory, immune modulator and blood pressure reducer [29,30].…”

Can propolis and caffeic acid phenethyl ester (CAPE) be promising agents against cyclophosphamide toxicity?

“…This marvelous compound has been used to prevent oxidative stress-based deterioration in cells/tissues/organs in both cell culture and experimental animals. Lately, the protection of CAPE on central and peripheral nervous system as well as a reproductive system have been extensively reviewed [ 3 - 5 ]. Cyclophosphamide (CP) is an anticancer chemotherapeutic drug classified as an alkylating agent.…”

In vitro and in vivo neuroprotective effect of caffeic acid phenethyl ester

“…Propolis is a mixture produced by honeybee, which have hundreds of polyphenols. Caffeic acid phenethyl ester (CAPE) [ Figure 1 ], an active component of honeybee propolis has been determined to have antioxidant, anti-inflammatory, antiviral, and anticancer activities [ 1 , 2 ]. It has been used to prevent oxidative stress-based deterioration in cells/tissues/organs in both cell culture and experimental animals.…”