Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability

Bortoleti, Bruna Taciane da Silva; Tomiotto-Pellissier, Fernanda; Gonçalves, Manoela Daiele; Miranda-Sapla, Milena Menegazzo; Assolini, João Paulo; Carloto, Amanda Cristina Machado; Lima, Débora Messagi; Silveira, Guilherme Ferreira; Almeida, Ricardo Sérgio; Costa, Idessânia Nazareth; Conchon‐Costa, Ivete; Pavanelli, Wander Rogério

doi:10.1016/j.phymed.2018.12.035

Cited by 27 publications

(12 citation statements)

References 35 publications

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“…As a mechanism of action, caffeic acid was able to alter promastigote cell morphology and cell volume accompanied by loss of mitochondrial integrity, increase in reactive oxygen species (ROS) production, phosphatidylserine exposure, and loss of plasma membrane integrity, suggesting an apoptosis-like process. Caffeic acid also increased TNF-α, ROS, and NO and reduced IL-10 levels, as well as iron availability (Bortoleti et al, 2019;Garcia et al, 2019). Through these results, it is possible to conclude that caffeic acid has leishmanicidal effects with a mechanism of action that triggers multiple targets that affect the viability of the parasite.…”

Section: Caffeic Acidmentioning

confidence: 79%

“…After the in silico evaluation, bioguide assays were developed. Caffeic acid showed IC 50 values of 12.5 µg/mL against promastigotes (Bortoleti et al, 2019), 16.0 µM against intracellular amastigotes of Leishmania amazonensis (Montrieux et al, 2014) and 21.9 µM for intracellular amastigotes of L. infantum (Garcia et al, 2019) (Table 4). Regarding these promising in vitro results, the effects of caffeic acid in an in vivo model of infection were examined.…”

Section: Caffeic Acidmentioning

confidence: 99%

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Use of Natural Products in Leishmaniasis Chemotherapy: An Overview

et al. 2020

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Leishmaniasis is an infectious parasitic disease that is caused by protozoa of the genus Leishmania, a member of the Trypanosomatidae family. Leishmaniasis is classified by the World Health Organization as a neglected tropical disease that is responsible for millions of deaths worldwide. Although there are many possible treatments for leishmaniasis, these treatments remain mostly ineffective, expensive, and long treatment, as well as causing side effects and leading to the development of resistance. For novel and effective treatments to combat leishmaniasis, many research groups have sought to utilize natural products. In addition to exhibiting potential as therapeutic compounds, natural products may also contribute to the development of new drugs based on their chemical structures. This review presents the most promising natural products, including crude extracts and isolated compounds, employed against Leishmania spp.

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Section: Caffeic Acidmentioning

confidence: 79%

Section: Caffeic Acidmentioning

confidence: 99%

Use of Natural Products in Leishmaniasis Chemotherapy: An Overview

et al. 2020

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“…The antiparasitic effect of propolis could be explained by the presence of caffeic acid in this material, which is one of the biologically active ingredients of propolis that induces morphological changes in the parasitic cells, integrity of mitochondria and cellular plasma membrane, consequently promoting apoptosis. Caffeic acids also increase the antiparasitic activity of macrophages by promoting the expression of ROS (Bortoleti et al ., 2019). Furthermore, the antiparasitic effect of propolis could be attributed to the antioxidant effect of the flavonoids that are concentrated in propolis or its immunomodulatory properties via the augmentation of nonspecific host defence mechanisms following macrophage activation (Al-Ghandour et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight

et al. 2022

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Trichinosis is a serious zoonotic disease that causes human morbidity and mortality. New effective natural remedies with minimal side effects that are well tolerated are needed to treat both enteral and parenteral trichinosis. This study evaluated the efficacy of selenium (Se), Se nanoparticles (SeNPs) and Egyptian propolis compared with albendazole as antiparasitic, anti-inflammatory and anti-angiogenic agents for treating murine trichinosis. We used parasitological, histopathological and immunohistochemical assays, as well as scanning electron microscopy, to examine adult worms. Overall, 80 Swiss albino male mice were divided into eight groups, with ten mice in each group, as follows: negative control, positive control, albendazole, propolis, Se, combination of propolis and Se, SeNPs and combination of SeNPs and propolis. Mice were slaughtered seven and 35 days after infection to examine the intestinal and muscular phases, respectively. This study demonstrated the efficacy of the combination of SeNPs and propolis. As revealed by electron microscopy, this combination caused damage to the adult worm cuticle. Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles. In conclusion, the combination of SeNPs and propolis had antiparasitic, anti-inflammatory and anti-angiogenic effects on trichinosis. Consequently, this combination could be used as a natural alternative therapy to albendazole for treating trichinosis.

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“…49 Also, caffeic acid induces high ROS generation through oxidative burst, which leads to the death of Leishmania amazonensis promastigotes. 50 The health of any cell depends on its intact boundary or cellular membrane. Therefore, loss in the cellular membrane or disrupted cellular membrane leads to cell death due to disturbance in cell machinery.…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial potential of immunomodulator gallic acid against experimental murine visceral leishmaniasis

Keshav

Goyal

Kaur

2021

Parasite Immunology

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Neglected tropical diseases (NTDs) affect nearly one-sixth of the world's population, and leishmaniasis is one such disease. The eukaryotic protozoan parasite of genus Leishmania with nearly 20 species is known to cause the disease leishmaniasis and is prevalent in nearly hundred countries throughout the world. 1 Female phlebotomine sand flies are transmission vectors of the disease. Parasite species and host immune response determine the disease outcome, and the three major manifestations are cutaneous, visceral and mucocutaneous leishmaniasis. 2 Visceral leishmaniasis (VL) is the deadliest of all the forms and is ranked as one of the world's leading parasitic killers with approximately 600 million people at risk across the globe and 7 th in loss of disability-adjusted life years (DALYs) (DNDi reports). In the Indian subcontinent and Africa, L. donovani is the aetiological agent of VL, while in the Mediterranean Basin, it is caused by L. infantum. 3 According to World Health Organization (WHO 2018), more than 95% of VL cases are clustered in 10 countries: India,

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Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability

Cited by 27 publications

References 35 publications

Use of Natural Products in Leishmaniasis Chemotherapy: An Overview

Use of Natural Products in Leishmaniasis Chemotherapy: An Overview

Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight

Antileishmanial potential of immunomodulator gallic acid against experimental murine visceral leishmaniasis

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