Caffeic Acid and Diseases—Mechanisms of Action

Pavlíková, Nela

doi:10.3390/ijms24010588

Cited by 51 publications

(39 citation statements)

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“…Caffeic acid shows effects on various types of cancers, obesity and neurodegenerative diseases (Pavlíková, 2022). It can be formed by one step hydroxylation at the three‐position on the benzene ring of p ‐coumaric acid.…”

Section: P‐coumaric Acid Derivativesmentioning

confidence: 99%

“…Metabolites Abbreviations: 4HPP, 4-hydroxyphenylpyruvate; 4HPAA, 4-hydroxyphenylacetaldehyde; Enzyme Abbreviations: AAS, aromatic amino acid decarboxylases; ADHs, alcohol dehydrogenases; ARO8/ARO9, aromatic amino acid transaminase; ARO10, phenylpyruvate decarboxylase; HpaBC, 4-hydroxyphenylacetate-3-hydroxylase; UGTs, uridine diphosphate glucosyltransferase.F I G U R E 3 The biosynthetic pathway of phenylpropanoic acids and stilbenes. Metabolites Abbreviations: 4HPP, 4-hydroxyphenylpyruvate; 4HPL, p-hydroxyphenyllactic acid; Enzyme Abbreviations: 4CL, 4-coumaryl CoA-ligase; TAL, tyrosine ammonia-lyase; STS, stilbene synthase; ROMT, resveratrol O-methyltransferase; HpaBC, 4-hydroxyphenylacetate-3-hydroxylase; COMT, caffeic acid O-methyltransferase; RAS, rosmarinic acid synthase; AAS, aromatic amino acid decarboxylases; ADHs, alcohol dehydrogenases; UGTs, uridine diphosphate glucosyltransferases; ARO8/ARO9, aromatic amino acid transaminase; ARO10, phenylpyruvate decarboxylase; LDH, D -lactate dehydrogenase.4.2 | Synthesis of phenylpropanoic acids4.2.1 | Synthesis of caffeic acidCaffeic acid shows effects on various types of cancers, obesity and neurodegenerative diseases(Pavlíková, 2022). It can be formed by one step hydroxylation at the three-position on the benzene ring of p-coumaric acid.…”

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Yeast: A platform for the production of _L‐tyrosine derivatives

Guo

et al. 2023

Yeast

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L -Tyrosine derivatives are widely applied in the pharmaceutical, food, and chemical industries. Their production is mainly confined to chemical synthesis and plant extract. Microorganisms, as cell factories, exhibit promising advantages for valuable chemical production to fulfill the increase in the demand of global markets. Yeast has been used to produce natural products owing to its robustness and genetic maneuverability. Focusing on the progress of yeast cell factories for the production of L -tyrosine derivatives, we summarized the emerging metabolic engineering approaches in building L -tyrosoineoverproducing yeast and constructing cell factories of three typical chemicals and their derivatives: tyrosol, p-coumaric acid, and L -DOPA. Finally, the challenges and opportunities of L -tyrosine derivatives production in yeast cell factories were also discussed.aromatic amino acids, cell factory, L -tyrosine derivatives, synthetic biology, yeastis an essential amino acid nutrient with diverse applications in food, medicine, and chemical industries. Its derivatives, including Hydroxytyrosol S. cerevisiae Glucose 5L fed-batch 6970 H. Liu, Wu, et al. (2022) Salidroside S. cerevisiae Glucose 5L fed-batch 26,550 H. Liu, Tian, et al. (2021) p-Coumaric acid derivatives p-coumaric acid S. cerevisiae Glucose 1L fed-batch 12,500 Q. Liu, Yu, et al. (2019) p-coumaric acid S. cerevisiae Xylose 1L fed-batch 242 Borja et al. (2019) Caffeic acid S. cerevisiae Carboxymethylcellulose Shake flask 16.91 M. Cai et al. (2022) Caffeic acid S. cerevisiae Glucose 1.2L fed-batch 5500 R. Chen et al. (2022) Caffeic acid Candida glycerinogenes Glucose and Xylose 5L fed-batch 431.45 X.-H. Wang et al. (2022) Rosmarinic acid S. cerevisiae Glucose Shake flask 208 P. Zhou et al. (2022) Ferulic Acid S. cerevisiae Glucose 1.2L fed-batch 3800 R. Chen et al. (2022) Resveratrol S. cerevisiae Glucose and Ethanol shake flask 187 Costa et al. (2021) Resveratrol S. cerevisiae Lactose Shake flask 210 Costa et al. (2022) Resveratrol Scheffersomyces stipitis Cellobiose Shake flask 529.8 Kobayashi et al. (2021) Resveratrol S. stipitis Sucrose Shake flask 668.6 Kobayashi et al. (2021) Resveratrol Pichia pastoris Glycerol 250 mL fed-batch 1825 Kumokita et al. (2022) Pterostilbene S. cerevisiae Glucose Shake flask 34.93 M. Li et al. (2016) Pinostilbene S. cerevisiae Glucose Shake flask 5.52 M. Li et al. (2016) Naringenin S. cerevisiae Glucose Shake flask 203.49 Tong et al. (2022) Naringenin S. cerevisiae Glucose 5L fed-batch 1184.1 H. Li et al. (2022) Naringenin Yarrowia lipolytica Glucose 3L fed-batch 898 Palmer et al. (2020) Naringenin P. pastoris Glycerol 250 mL fed-batch 1067 Kumokita et al. (2022) Naringenin Y. lipolytica Glucose Shake flask 252.4 Lv et al. (2019) Eriodictyol Y. lipolytica Glucose Shake flask 134.2 Lv et al. (2019) Phloretin S. cerevisiae Glucose 5L fed-batch 619.5 C. Jiang et al. (2020) Apigenin Y. lipolytica Glucose Shake flask 80.74 Vanegas et al. (2018) Luteolin Y. lipolytica Glucose Shake flask 47.9 Vanegas et al. (2018) Kaempferol S. ...

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Section: P‐coumaric Acid Derivativesmentioning

confidence: 99%

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confidence: 99%

Yeast: A platform for the production of _L‐tyrosine derivatives

Guo

et al. 2023

Yeast

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“…Therefore, it is crucial to monitor and detect pesticides in foods and vegetables to mitigate these risks. Caffeic acid (CA), a naturally occurring organic small molecule frequently present in vegetables and fruits, belongs to the phenolic and cinnamic acid group and exhibits excellent pharmacological functions such as anticancer, anti-inflammatory, and antioxidant properties in medicine. − The recommended daily intake of CA is 0.3–0.9 g . For medical diagnostics and information security applications, the development of MRLI capable of detecting both CA and its chemical derivatives is essential.…”

Section: Introductionmentioning

confidence: 99%

Efficient Multi-stimulus-Responsive Luminescent Eu(III)-Modified HOFs Materials: Detecting Thiram and Caffeic Acid and Constructing a Flexible Substrate Anti-counterfeiting Platform

Yang,

Zhu,

Yan

2024

ACS Appl. Mater. Interfaces

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The powerful capability of multi-stimulus-responsive luminescent hydrogen-bonded organic frameworks (HOFs) to respond to external chemical or physical stimuli in various manners makes them appealing in the luminescence anti-counterfeiting field. Herein, a novel Eu 3+ -functionalized HOF (Eu@GC-2) that combines the emission of HOFs with the characteristic emission of Eu 3+ ions has been successfully synthesized, which can generate various fluorescence at different excitation wavelengths. Eu@GC-2 has enormous potential as a raw material for a paper-based sensor that is designed for detecting the pesticides thiram and caffeic acid in crops with favorable selectivity, anti-interference, and high efficiency. Based on the above excellent properties, Ln 3+ -functionalized HOFs (Ln@GC-2) were then employed to produce four luminescent anti-counterfeiting inks. With the incorporation of back-propagation neural network and Gray code conversion functions, a multi-stimulus-responsive luminescent anti-counterfeiting platform, coregulated by the excitation light and the chemical reagent, has been constructed. This approach can not only achieve multiple encryptions and fast information identification but also enhance the code-breaking complexity, making it an efficient strategy for information encryption and decryption.

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“…Natural medicines are an important way to develop low‐toxicity and highly effective targeted drugs. Caffeic acid, an organic acid widely found in beverages such as coffee, chocolate and black tea, CA has a wide range of pharmacological effects including antioxidant, anti‐inflammatory, bacteriostatic, and neuroprotective effects 9,10 . Supplementation with CA has been reported in the literature to inhibit the growth of major bacterial strains isolated from clinical bovine mastitis milk samples.…”

Section: Introductionmentioning

confidence: 99%

Caffeic acid attenuates tissue damage and inflammatory response in Klebsiella pneumonia by modulating AhR‐Src‐STAT3‐IL‐10 signaling pathway

Chen,

Jiang,

Zeng

et al. 2023

Environmental Toxicology

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CA is a plant derivative with antibacterial and antiviral pharmacological effects, however, the therapeutic effect of CA on Klebsiella pneumonia and its mechanism study is still unclear. A rat KP model was established in vitro, a pneumonia cell model was established in vivo, the histopathological changes in the lungs were observed by HE staining after CA treatment, the expression of relevant inflammatory factors was detected by ELISA, the changes in the expression of proteins related to the AhR‐Src‐STAT3‐IL‐10 signaling pathway were detected by Western blot and immunofluorescence in the lungs, and the interactions between the proteins were verified by COIP relationship. The results showed that CA was able to attenuate the injury and inflammatory response of lung tissues, and molecular docking showed that there were binding sites between CA and AhR, and COIP demonstrated that AhR interacted with both STAT3 and Ser. In addition, CA was able to up‐regulate the expression levels of pathway‐related proteins of AhR, IL‐10, p‐Src, and p‐STAT3, and AhR knockdown was able to reduce LPS‐induced inflammatory responses and up‐regulate pathway‐related proteins, whereas CA treatment of AhR‐knockdown‐treated A549 cells did not show any statistically significant difference compared with the AhR knockdown group, demonstrating that CA exerts its pharmacological effects. These findings elucidated the mechanism of CA in the treatment of KP and demonstrated that CA is a potential therapeutic agent for KP.

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Caffeic Acid and Diseases—Mechanisms of Action

Cited by 51 publications

References 121 publications

Yeast: A platform for the production of _L‐tyrosine derivatives

Yeast: A platform for the production of _L‐tyrosine derivatives

Efficient Multi-stimulus-Responsive Luminescent Eu(III)-Modified HOFs Materials: Detecting Thiram and Caffeic Acid and Constructing a Flexible Substrate Anti-counterfeiting Platform

Caffeic acid attenuates tissue damage and inflammatory response in Klebsiella pneumonia by modulating AhR‐Src‐STAT3‐IL‐10 signaling pathway

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Caffeic Acid and Diseases—Mechanisms of Action

Cited by 51 publications

References 121 publications

Yeast: A platform for the production of L‐tyrosine derivatives

Yeast: A platform for the production of L‐tyrosine derivatives

Efficient Multi-stimulus-Responsive Luminescent Eu(III)-Modified HOFs Materials: Detecting Thiram and Caffeic Acid and Constructing a Flexible Substrate Anti-counterfeiting Platform

Caffeic acid attenuates tissue damage and inflammatory response in Klebsiella pneumonia by modulating AhR‐Src‐STAT3‐IL‐10 signaling pathway

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Yeast: A platform for the production of _L‐tyrosine derivatives

Yeast: A platform for the production of _L‐tyrosine derivatives