Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy

Maity, Swastika; Kinra, Manas; Nampoothiri, Madhavan; Arora, Devinder; Pai, K. Sreedhara Ranganath; Mudgal, Jayesh

doi:10.1007/s11696-021-01947-7

Cited by 23 publications

(17 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… CA’s synergistic action with other agents/drugs (neuroprotective) for inhibiting neurodegeneration. [Adapted from Maity et al ( 228 )]. This figure was drown by ChemBioDraw.…”

Section: Neuroprotective Effect Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

View full text Add to dashboard Cite

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.

show abstract

“… CA’s synergistic action with other agents/drugs (neuroprotective) for inhibiting neurodegeneration. [Adapted from Maity et al ( 228 )]. This figure was drown by ChemBioDraw.…”

Section: Neuroprotective Effect Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Caffeic acid is a constituent of hydroxycinnamic acid, which is a very common dietary ingredient for humans. This acid has different biological activities, such as antibacterial activity, antioxidant properties, antiatherosclerotic activity, immunostimulant activity, anti-inflammatory/analgesic activity, antiviral activity, and cardioprotective and antiproliferative activity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Basil (Ocimum basilicum L.) Leaves as a Source of Bioactive Compounds

Romano

Luca

Aiello

et al. 2022

Foods

View full text Add to dashboard Cite

Basil (Ocimum basilicum L.) is an annual spicy plant generally utilized as a flavouring agent for food. Basil leaves also have pharmaceutical properties due to the presence of polyphenols, phenolic acids, and flavonoids. In this work, carbon dioxide was employed to extract bioactive compounds from basil leaves. Extraction with supercritical CO2 (p = 30 MPa; T = 50 °C) for 2 h using 10% ethanol as a cosolvent was the most efficient method, with a yield similar to that of the control (100% ethanol) and was applied to two basil cultivars: “Italiano Classico” and “Genovese”. Antioxidant activity, phenolic acid content, and volatile organic compounds were determined in the extracts obtained by this method. In both cultivars, the supercritical CO2 extracts showed antiradical activity (ABTS●+ assay), caffeic acid (1.69–1.92 mg/g), linalool (35–27%), and bergamotene (11–14%) contents significantly higher than those of the control. The polyphenol content and antiradical activity measured by the three assays were higher in the “Genovese” cultivar than in the “Italiano Classico” cultivar, while the linalool content was higher (35.08%) in the “Italiano Classico” cultivar. Supercritical CO2 not only allowed us to obtain extracts rich in bioactive compounds in an environmentally friendly way but also reduced ethanol consumption.

show abstract

“…However, this critical point we need to confirm to future study. CA is an excellent synergy compound ( 93 ). In drug resistant Listeria monocytogenes , 1.5 mg/mL of CA in combination treatment with 50 mg/L of fosfomycin enhanced the antimicrobial activity from 5% of fosfomycin alone to 82% of the fosfomycin and CA combination, which might be by acting as the FosX gene inhibitor ( 94 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our research has some limitations, because the number of clinical V. cholerae strains was small. Furthermore, since CA has synergistic effects with various pharmaceutical entities ( 93 ), antimicrobial activity in combination with CGA or caffeine could be tested. This work, however, was intended as a pilot screening, to assess the antibacterial potential of extract against V. cholerae clinical drug-resistant strains.…”

Section: Discussionmentioning

confidence: 99%

Potential Antimicrobial Properties of Coffee Beans and Coffee By-Products Against Drug-Resistant Vibrio cholerae

et al. 2022

View full text Add to dashboard Cite

Vibrio cholerae is the causative organism of the cholera epidemic, and it remains a serious global health problem, particularly the multidrug-resistant strain, despite the development of several generic drugs and vaccines over time. Natural products have long been exploited for the treatment of various diseases, and this study aimed to evaluate the in vitro antibacterial activity of coffee beans and coffee by-products against V. cholerae antimicrobial resistant strains. A total of 9 aqueous extracts were investigated, including light coffee (LC), medium coffee (MC), dark coffee (DC), dried green coffee (DGC), dried red coffee (DRC), fresh red coffee (FRC), Arabica leaf (AL), Robusta leaf (RL), and coffee pulp (CP). The influential coffee phytochemicals, i.e., chlorogenic acid (CGA), caffeic acid (CA), and caffeine, were determined using HPLC. The antibacterial properties were tested by agar well-diffusion techniques, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were further determined against 20 V. cholerae isolates. The results revealed that all tested strains were sensitive to coffee extracts, with MIC and MBC values in the range of 3.125–25.0 mg/mL and 12.5–50.0 mg/mL, respectively. With a MIC of 6.25 mg/mL, DGC, DRC, and CP appeared to be the most effective compounds against 65, 60, and 55% of clinical strains, respectively. The checkerboard assay revealed that the combination of coffee extract and tetracycline was greater than either treatment alone, with the fractional inhibitory concentration index (FICI) ranging from 0.005 to 0.258. It is important to note that CP had the lowest FICI (0.005) when combined with tetracycline at 60 ng/mL, which is the most effective dose against V. cholerae six-drug resistance strains (azithromycin, colistin, nalidixic acid, sulfamethoxazole, tetracycline, and trimethoprim), with a MIC of 47.5 μg/mL (MIC alone = 12.5 mg/mL). Time killing kinetics analysis suggested that CA might be the most effective treatment for drug-resistant V. cholerae as it reduced bacterial growth by 3 log10 CFU/mL at a concentration of 8 mg/mL within 1 h, via disrupting membrane permeability, as confirmed by scanning electron microscopy (SEM). This is the first report showing that coffee beans and coffee by-product extracts are an alternative for multidrug-resistant V. cholerae treatment.

show abstract

Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy

Cited by 23 publications

References 99 publications

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Basil (Ocimum basilicum L.) Leaves as a Source of Bioactive Compounds

Potential Antimicrobial Properties of Coffee Beans and Coffee By-Products Against Drug-Resistant Vibrio cholerae

Contact Info

Product

Resources

About