2019
DOI: 10.1016/j.trecan.2019.09.010
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CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Abstract: Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, there has been a shift in the field to study CAF subpopulations and the emergent functions of these subsets in tumourigenesis. In this review, we explore how different aspects of CAF heterogeneity are defined and how t… Show more

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Cited by 232 publications
(234 citation statements)
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References 136 publications
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“…Cancer associated fibroblasts (CAFs) are important stromal cells within the tumor microenvironment that can be educated and/or recruited by tumor secreted factors. The capacity of CAFs to synthesize and remodel ECM components critically effects tumor progression (14). Understanding the nature of the heterotypic interactions between tumor cells, the ECM, and CAFs within the tumor microenvironment will offer insights into the mechanisms underpinning tumor progression and metastasis.…”
mentioning
confidence: 99%
“…Cancer associated fibroblasts (CAFs) are important stromal cells within the tumor microenvironment that can be educated and/or recruited by tumor secreted factors. The capacity of CAFs to synthesize and remodel ECM components critically effects tumor progression (14). Understanding the nature of the heterotypic interactions between tumor cells, the ECM, and CAFs within the tumor microenvironment will offer insights into the mechanisms underpinning tumor progression and metastasis.…”
mentioning
confidence: 99%
“…The study of the cellular interactions taking place between the cancer and stroma has recently emerged as an important topic in pancreatic cancer research [43][44][45]. Multiple new stromal targets of potential clinical importance in PDAC are currently being investigated [46]. Of these, the activated PSCs, also denoted cancer-associated fibroblasts, have gained particular interest [47].…”
Section: Discussionmentioning
confidence: 99%
“…The cell lines established in the present study may prove valuable in determining such lineage relationships. It is also a possibility that phenotypic and functional CAF heterogeneity re ects plasticity in a broader sense, and in general may be governed more or less by the tumor genotype as suggested in mouse models of pancreatic cancer (reviewed in [65]). In this context, the cell lines may serve to decipher whether a speci c tumor genotype instructs development of a particular stromal response independent of recipient initial stromal cell type.…”
Section: Discussionmentioning
confidence: 99%