Caesarean section: impact on mother and child

Boutsikou, Τheodora; Malamitsi-Puchner, A

doi:10.1111/j.1651-2227.2011.02477.x

Cited by 50 publications

(43 citation statements)

References 62 publications

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“…Based on 26 cohort studies, this metaanalysis indicates that children born by CS have a 16% higher The increased risk of asthma could be explained by several possible causal pathways. First, due to earlier planned CS date, gestational age as well as birthweight of children born by elective CS are generally smaller than that of emergency CS [43]. In USA, more than one-third of elective caesarean deliveries at term were performed before 39-week gestation.…”

Section: Discussionmentioning

confidence: 99%

Is elective cesarean section associated with a higher risk of asthma? A meta-analysis

Huang

Chen²,

Zhao³

et al. 2014

Journal of Asthma

104

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Section: Discussionmentioning

confidence: 99%

Is elective cesarean section associated with a higher risk of asthma? A meta-analysis

Huang

Chen²,

Zhao³

et al. 2014

Journal of Asthma

104

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“…Cesarean-born infants harbored bacterial communities similar to those found on the skin surface (48), lower numbers of beneficial bacteria, and a high proportion of potential pathogens (49). These microbial differences may account for increased incidence of food allergy, asthma, and type 1 diabetes (50). A close relationship between the mother's and child's body composition was found.…”

Section: Metabolomics In Pediatric Researchmentioning

confidence: 90%

Metabolomics perspectives in pediatric research

et al. 2013

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Increasing evidence points toward the critical and long-term involvement of prenatal and early nutrition and lifestyle on later health and disease risk predisposition. Metabolomics is now a well-established top-down systems biology approach that explores the genetic-environment-health paradigm. The generalization of such approaches has opened new research areas to deepen our current understanding of many physiological processes, as well as foods and nutrient functionalities in target populations. It is envisioned that this will provide new avenues toward preventive medicine and prognostic strategies for tailored therapeutic and personalized nutrition management. The development of systems biology approaches and the new generation of biomarker patterns will provide the opportunity to associate complex metabolic regulations with the etiology of multifactorial pediatric diseases. This may subsequently lead to the development of system mechanistic hypotheses that could be targeted with new nutritional personalized concepts. Therefore, this review aims to describe recent applications of metabolomics in preclinical and clinical fields with insights into disease diagnostics/monitoring and improvement of homeostasis metabolic regulation that may be translatable to novel therapeutic and nutrition advances in pediatric research. Over the past decades, awareness about the role of nutrition and lifestyle in health and disease risk management has increased, with key emphasis on the prevention of metabolic disorders, including cardiometabolic diseases and type 2 diabetes (1-3). In parallel, increasing evidence points toward the critical and long-term involvement of early nutrition and lifestyle on later health and disease risk predisposition (4). It therefore becomes pertinent to look at newborn metabolism, development, and nutritional requirements to understand the onset of child and adult physiological conditions. Pregnancy, childbirth, lactation, and human milk composition are influenced by the intake of foods (macro-and micronutrients), which subsequently determine both the short-and long-term health and nutritional outcomes of an individual (5). Therefore, it is essential to build knowledge not only on the metabolic dysregulations but also on the effects of specific foods to comprehensively document the metabolic processes associated with individual health at the different stages of the life cycle (Figure 1). This will allow us to formulate nutritional solutions to improve or circumvent certain metabolic imbalances.The generalization of systems biology approaches has opened new research areas to further our current understanding of many physiological processes, as well as the functionalities of foods and nutrients. In particular, metabolomics is recognized as a powerful top-down systems biology approach to understand the genetic-environment-health paradigm and to identify clinically relevant biomarkers. Its application in clinical studies is envisioned to shed new light on the regulatory processes of complex mammalian sy...

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“…Child and parental characteristics may serve as potential confounders for the studied association, since they may be associated with both the risk of cancer among parents and the risk of death among children [17][18][19][20][21][22][23]. We further obtained information on gestational age, mode of delivery and birth weight of the child, maternal smoking during early pregnancy (available since 1983), maternal age at child's birth, as well as the highest educational level and socio-economic classification of the parents (Table 1).…”

Section: Follow-upmentioning

confidence: 99%

Parental cancer diagnosis and child mortality—A population-based cohort study in Sweden

Chen

Sjölander

Valdimarsdóttir

et al. 2015

Cancer Epidemiology

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Caesarean section: impact on mother and child

Abstract: Decision for primary CS should take into consideration possible maternal/neonatal complications.

Cited by 50 publications

References 62 publications

Is elective cesarean section associated with a higher risk of asthma? A meta-analysis

Is elective cesarean section associated with a higher risk of asthma? A meta-analysis

Metabolomics perspectives in pediatric research

Parental cancer diagnosis and child mortality—A population-based cohort study in Sweden

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