Caesarean delivery, caesarean delivery on maternal request and childhood overweight: a <scp>C</scp>hinese birth cohort study of 181 380 children

Li, Huihui; Ye, Rongwei; Pei, Lijun; Ren, Aiguo; Zheng, Xiaoying; Liu, Jufen

doi:10.1111/j.2047-6310.2013.00151.x

Cited by 66 publications

(77 citation statements)

References 30 publications

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“…Infants born by CS have a higher incidence of respiratory distress 38 and appear to be at higher risk for developing asthma and atopy 39 , obesity 40 and type 1 diabetes 41 . It has been hypothesized that delayed and aberrant intestinal colonization might contribute to this risk conferred by CS.…”

Section: West 11mentioning

confidence: 99%

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

West

Renz²,

Jenmalm

et al. 2015

Journal of Allergy and Clinical Immunology

222

165

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Rapid environmental transition and modern lifestyles are likely driving changes in the biodiversity of the human gut microbiota. With clear effects on physiologic, immunologic, and metabolic processes in human health, aberrations in the gut microbiome and intestinal homeostasis have the capacity for multisystem effects. Changes in microbial composition are implicated in the increasing propensity for a broad range of inflammatory diseases, such as allergic disease, asthma, inflammatory bowel disease (IBD), obesity, and associated noncommunicable diseases (NCDs). There are also suggestive implications for neurodevelopment and mental health. These diverse multisystem influences have sparked interest in strategies that might favorably modulate the gut microbiota to reduce the risk of many NCDs. For example, specific prebiotics promote favorable intestinal colonization, and their fermented products have anti-inflammatory properties. Specific probiotics also have immunomodulatory and metabolic effects. However, when evaluated in clinical trials, the effects are variable, preliminary, or limited in magnitude. Fecal microbiota transplantation is another emerging therapy that regulates inflammation in experimental models. In human subjects it has been successfully used in cases of Clostridium difficile infection and IBD, although controlled trials are lacking for IBD. Here we discuss relationships between gut colonization and inflammatory NCDs and gut microbiota modulation strategies for their treatment and prevention

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Section: West 11mentioning

confidence: 99%

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

West

Renz²,

Jenmalm

et al. 2015

Journal of Allergy and Clinical Immunology

222

165

View full text Add to dashboard Cite

show abstract

“…Apesar do benefício da cesárea de prevenir agravos e salvar vidas, vários estudos [4][5][6][7][8][9][10] vêm abordando associação do seu uso indiscriminado e a morbimortalidade materna e infantil. Estudos atribuem também efeitos em curto e longo prazo da cesárea na saúde das mulheres e crianças, como maior proporção de trabalho de parto prematuro e infecção puerperal 11 , maior risco no segundo parto após cesárea planejada para hemorragia, ruptura uterina e óbito fetal 5 , incidência de prematuridade e baixo peso ao nascer 6 , e até possibilidade de associação com o sobrepeso na infância 7 , adolescência e na idade adulta jovem 8 . Na última década, no estado do Paraná, dentre os óbitos maternos mais de 65% das mulheres haviam sido submetidas ao parto cesáreo, o que significou um risco de 70 óbitos maternos por 100 mil nascidos vivos e um risco relativo de morte por cesárea em relação ao parto normal 1,9 vezes maior, independente da causa do óbito materno 3,9 .…”

Section: Tendência Temporal Da Via De Parto De Acordo Com a Fonte De unclassified

Tendência temporal da via de parto de acordo com a fonte de financiamento

Paris¹,

Monteschio²,

Oliveira³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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“…This is then followed by the typically slower (compared to vaginally delivered infants) acquisition of a more complex microbiota [42,43]. Infants born by means of CS are at higher risk for respiratory distress [44], asthma and atopy [45], as well as obesity [46], and type I diabetes [47]. Furthermore, CS involves antibiotic exposure and can delay the onset of breastfeeding, which negatively influence the establishment of a normal healthy gut microbiota [14,48,49].…”

Section: Observational Studies Support a Critical Role Of The Gi Micrmentioning

confidence: 99%

The Gastrointestinal Tract Microbiota and Allergic Diseases

Kyburz

Müller²

2016

Dig Dis

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The gastrointestinal (GI) tract microbiota is required for optimal digestion of foods, for the development of resistance against pathogens (termed colonization resistance), for the development of mucosa-associated lymphoid tissue, and for local as well as systemic immune homeostasis. Certain constituents of the GI tract microbiota are widely recognized as critical regulators and modulators of their host's immune response. These include bacterial members of the microbiota as well as parasitic nematodes. Immune regulation by immunomodulatory members of the GI microbiota primarily serves to subvert host antimicrobial immune defenses and promote persistent colonization, but as a side effect may prevent or suppress immunological disorders resulting from inappropriate responses to harmless antigens, such as allergy, colitis or autoimmunity. Many of the best understood GI-resident immunomodulatory species have co-evolved with their mammalian hosts for tens of thousands of years and masterfully manipulate host immune responses. In this review, we discuss the epidemiological evidence for the role of the GI tract microbiota as a whole, and of specific members, in protection against allergic and other immunological disorders. We then focus on the mechanistic basis of microbial immunomodulation, which is presented using several well-understood paradigmatic examples, that is, helminths, Helicobacter pylori, Bifidobacteria and Lactobacilli. In a final chapter, we highlight past and ongoing attempts at harnessing the immunomodulatory properties of GI microbiota species and their secreted products for intervention studies and describe the promises and limitations of these experimental approaches. The effects of pro- and prebiotics, bacterial lysates, as well as of fecal microbiota transplantation are presented and compared.

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Caesarean delivery, caesarean delivery on maternal request and childhood overweight: a Chinese birth cohort study of 181 380 children

Abstract: Caesarean delivery including non-medically indicated maternal request caesarean delivery compared with vaginal delivery modestly increases childhood overweight risk.

Cited by 66 publications

References 30 publications

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

Tendência temporal da via de parto de acordo com a fonte de financiamento

The Gastrointestinal Tract Microbiota and Allergic Diseases

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