Caecal perforation in a renal transplant patient with disseminated histoplasmosis.

Brett, Mary; Kwan, Jonathan; Bending, M. R.

doi:10.1136/jcp.41.9.992

Cited by 25 publications

(14 citation statements)

References 23 publications

(3 reference statements)

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“…Pulmonary involvement is common, and immunosuppressed patients can develop severe life-threatening pneumonia, although other varied manifestations have been observed in transplant patients (48,125,259,354,401,414). In this respect, the presentation and clinical course of histoplasmosis in the SOT population appear to be somewhat less severe than histoplasmosis in the AIDS population (393).…”

Section: Infections Caused By Histoplasma Capsulatummentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Infections Caused By Histoplasma Capsulatummentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…The typical manifestations of colonic histoplasmosis are abdominal pain and diarrhea, although hematochezia and perforation resulting in peritonitis have been reported 6, 7, 12, 19–25. In 1908, Darling26 first described colonic ulcers visualized at the time of autopsy which were attributed to histoplasmosis.…”

Section: Discussionmentioning

confidence: 99%

“…Immunosuppression has been shown to be a risk factor for dissemination 2. Although this mycosis has been well described in immunocompromised patients,3–18 disseminated histoplasmosis has rarely been reported in liver transplant patients.…”

mentioning

confidence: 99%

Disseminated histoplasmosis in a liver transplant recipient

Lisker‐Melman

Korenblat

et al. 2006

Liver Transpl

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A 61-yr-old liver transplant recipient presented with abdominal cramping and nonbloody diarrhea resulting in orthostasis. Multiple ulcerations throughout the colon were seen during endoscopy, and biopsies from the ulcer edges revealed histoplasmosis. Treatment with a course of itraconazole improved the diarrhea. The patient later presented with pericarditis and symptomatic pleural effusions, the latter of which was confirmed to be a result of disseminated histoplasmosis. Treatment with amphotericin B led to resolution. Histoplasmosis should be considered in liver transplant patients with diarrhea and large ulcers in the colon. The presence of disseminated histoplasmosis should be ruled out once colonic histoplasmosis has been diagnosed.

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“…In the endemic areas, the fungus grows in the soil and can be isolated from the feces of birds and poultry [14]. In the great majority of patients, the infection is self-limited and localized, affecting only the lungs, the cervical lymph nodes, or both.…”

Section: Discussionmentioning

confidence: 99%

Histoplasmosis of the colon in patients with AIDS: imaging findings in four cases.

Balthazar¹,

Megibow²,

Barry³

et al. 1993

American Journal of Roentgenology

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Caecal perforation in a renal transplant patient with disseminated histoplasmosis.

Cited by 25 publications

References 23 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Disseminated histoplasmosis in a liver transplant recipient

Histoplasmosis of the colon in patients with AIDS: imaging findings in four cases.

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