Cadmium toxicity and autophagy: a review

Global threat posed by metals and metalloids in the changing environment: a One Health approach to mechanisms of toxicity

“…Cd can activate as well as inhibit autophagy by targeting autophagic membrane formation and vesicle fusion with lysosomes. The molecular mechanisms of autophagy and the contribution to Cd-induced damage to different organ systems, such as the liver and kidney, are reviewed by Shao et al (2024).…”

“…In mammalians, speciation of MMs determines their transport modality in the blood (Doroudian et al 2023) and distribution within cells, tissues and organs (Thévenod and Lee 2024). At the cellular level, metals directly interact with numerous biological molecules, such as lipids (Issler et al 2024), eliciting toxicity and cell death (Pradhan et al 2024;Shao et al 2024). Furthermore, combinations of trace elements with MMs have consequences on the bioinorganic chemistry of MMs (Doroudian et al 2023), interaction with organic molecules (Issler et al 2024) and even markers of organ injury (Ortega-Romero et al…”