Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

Byber, Katarzyna; Lison, Dominique; Verougstraete, Violaine; Dressel, Holger; Hotz, Peter Eggenberger

doi:10.3109/10408444.2015.1076375

Cited by 74 publications

(30 citation statements)

References 258 publications

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“…In contrast to previous epidemiological studies, we excluded the ICD‐9 codes 587‐599 that include unspecified renal sclerosis, small kidney of unknown origin, calculus of kidney and ureter, and urethral stricture, as we intended to focus on those kidney diseases that have been mainly associated with the exposure to heavy metals in the scientific literature …”

Section: Methodsmentioning

confidence: 99%

“…We took into consideration the two pollutants cadmium and fine PM2.5 as they represent, in Taranto, a tracer of anthropogenic and particularly industrial emissions, and because they have been associated with several adverse kidney outcomes. In fact, a number of epidemiological studies have shown an association between exposure to cadmium and adverse kidney outcomes . With regard to PM2.5, recent experimental and epidemiological studies have provided evidence that PM2.5 exposure is associated with decreased kidney function, and high rate of kidney disease …”

Section: Methodsmentioning

confidence: 99%

“…In epidemiological studies, both acute and chronic occupational exposure to high levels of heavy metals, in particular to cadmium, lead, and arsenic, has been associated with kidney disease. Among the heavy metals, cadmium is considered to be the most nephrotoxic . Although it is well established that occupational exposure to high levels of cadmium, lead, and arsenic may cause kidney damage, few epidemiological studies have evaluated which adverse consequences for renal function can be produced by long term environmental exposure in populations living in proximity of polluted industrial sites …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatial distribution of kidney disease in the contaminated site of Taranto (Italy)

Benedetti

Santis

Manno

et al. 2017

American J Industrial Med

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spatial distribution of kidney disease in the contaminated site of Taranto (Italy)

Benedetti

Santis

Manno

et al. 2017

American J Industrial Med

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“…Evidence of kidney effects of some environmental chemicals has been investigated in other systematic analyses for both arsenic (Zheng et al, 2014) and cadmium (Byber et al, 2016) in adult populations. The systematic review herein evaluated the current body of literature regarding environmental chemical exposures and pediatric renal outcomes.…”

Section: Dscussionmentioning

confidence: 99%

Environmental exposures and pediatric kidney function and disease: A systematic review

Zheng

Sanders

Saland

et al. 2017

Environmental Research

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Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.

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“…Currently, the most convincing adverse effects of long-term Cd exposure are kidney injury [1], bone damage, and cancer [2]. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) established a provisional tolerable monthly intake (PTMI) level of 25 μg/kg bodyweight (bw)/month [3].…”

Section: Background and Introductionmentioning

confidence: 99%

Dietary cadmium exposure assessment in rural areas of Southwest China

Huo

Huang

et al. 2018

PLoS ONE

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Dietary exposure of cadmium (Cd) has not been studied in Southwest China. The objective of the study was to determine the pollution characteristics and contamination levels in various agriculture products in Southwest China and to conduct a comparison of dietary exposure assessment of Cd in polluted and non-polluted areas. Results showed that the mean Cd contents in rice were 0.53 and 0.52 mg/kg in the high-polluted and low-polluted areas, respectively, with the average value was 0.03 mg/kg in the control area. The mean dietary Cd exposure from rice and vegetables of the selected non-occupational residents in Southwest China was 113.10 μg/kg bodyweight (bw)/month, 88.80 μg/kg bw/month, and 16.50 μg/kg bw/month in the high-polluted, low-polluted, and control areas, respectively, which correspond to 4.5 times, 3.6 times, and 0.66 times of the provisional tolerable monthly intake (25 μg/kg bw/month) established by the Joint FAO/WHO Expert Committee on Food Additives. The findings indicated that the risk for Cd exposure of residents was high due to home-grown food (most especially rice) being near polluted areas and is of great concern.

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Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

Abstract: This qualitative systematic review does not support the contention that human exposure to Cd leads to progressive CKD.

Cited by 74 publications

References 258 publications

Spatial distribution of kidney disease in the contaminated site of Taranto (Italy)

Spatial distribution of kidney disease in the contaminated site of Taranto (Italy)

Environmental exposures and pediatric kidney function and disease: A systematic review

Dietary cadmium exposure assessment in rural areas of Southwest China

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