Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases

Nguyen, Hai Duc; Kim, Min-Sun

doi:10.1016/j.envpol.2022.119780

Cited by 48 publications

(19 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 The Ministry of Korea suggested 1.7 μg/L as the cutoff point for serum cadmium in the adult population. 12 Furthermore, a reference limit for serum mercury of 4 to 5 μg/L was suggested by the World Health Organization. 40 Our current study suggests that the threshold values of heavy metals linked to chronic kidney failure should be lower than the previous references, especially mercury and lead (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidence indicates that heavy metals play a crucial role in the pathophysiology of CKD, as well as menopause status (eg, increased ovarian aging and earlier age at natural menopause) 15,16 . On the other hand, heavy metals are well-known as the risk factors for cardiovascular diseases and diabetes, which are the key causes of CKD 3,6,8,10-12,17-19 . However, the effects of heavy metals on CKD were inconsistent, as was the limitation of this evidence in premenopausal and postmenopausal women.…”

mentioning

confidence: 99%

“…Thus, heavy metal exposure is inevitable, especially during urbanization, industrialization, and modernization, because the majority of them are long-lasting, nonbiodegradable chemicals with a tendency to bioaccumulate in living things 9-11 . Cadmium, lead, and mercury not only have no biological function but are also hazardous to humans 6,12 . These three substances are among the 10 that the World Health Organization has recognized as serious environmental pollutants that threaten human health 13 .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women

Nguyen

2023

Menopause

Self Cite

View full text Add to dashboard Cite

Objective: To evaluate the relationships between heavy metals (cadmium, lead, and mercury) and their mixtures and estimated glomerular filtration rate (eGFR) in premenopausal and postmenopausal women.Methods: Using data from the Korean National Health and Nutrition Examination Survey (2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017), multivariate linear regression models, marginal effects, and weighted quantile sum regression, we assessed the associations between single heavy metals and their mixtures and eGFR among 5,372 women.Results: Risks of reduced eGFR, comorbidities, and heavy metal exposure were found to be higher in postmenopausal women than in premenopausal women. A negative association of cadmium (β = −2.97; 95% CI, −5.10 to −0.85) and a positive association of mercury (β = 2.97; 95% CI, 1.49 to 4.44), with eGFR in postmenopausal women. Inverse associations of lead with eGFR in both premenopausal women (β = −4.75; 95% CI, −6.04 to −3.46) and postmenopausal women (β = −4.54; 95% CI, −6.96 to −2.13). Interactions were identified between lead and mercury, as well as cadmium and lead for eGFR among premenopausal women (β = −2.04; 95% CI, −2.98 to −1.10) and postmenopausal women (β = −3.52; 95% CI, −6.04 to −1.01), respectively. There was a negative association between mixed heavy metals and eGFR in both premenopausal women (β = −2.23; 95% CI, −3.51 to −0.96) and postmenopausal women (β = −3.86; 95% CI, −6.89 to −0.83). Lead was found as a key chemical related to reduced eGFR. Cutoff values for each heavy metal concentration related to eGFR were provided.Conclusion: Postmenopausal women were more influenced by mixed heavy metals' effects on kidney function than premenopausal women. Early interventions (eg, water filtering, heavy metal yearly screening) in women, especially postmenopausal women, are needed to reduce the incidence of chronic kidney disease.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women

Nguyen

2023

Menopause

Self Cite

View full text Add to dashboard Cite

show abstract

“…It can destroy the human immune system and cause various neurological diseases if it gets into the human body and is enriched to a certain amount. 3 Moreover, lead ions have a negative impact on the metallurgical process and reduce the purity of metal products. More and more metallurgical factories try to remove lead ions to stabilize metallurgical process parameters and conditions.…”

Section: Introductionmentioning

confidence: 99%

“…It can create serious hazards to the environment, and it enters the water environment through industrial production and human activities. It can destroy the human immune system and cause various neurological diseases if it gets into the human body and is enriched to a certain amount . Moreover, lead ions have a negative impact on the metallurgical process and reduce the purity of metal products.…”

Section: Introductionmentioning

confidence: 99%

Design of Zr-MOFs by Introducing Multiple Ligands for Efficient and Selective Capturing of Pb(II) from Aqueous Solutions

Liu

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The existence of lead ions seriously affects the quality of many metal products in metallurgical enterprises. Currently, the various methods of lead-ion removal tried by researchers will affect valuable metals in the removal process, thus resulting in low economic efficiency. In this study, a novel metal–organic framework adsorbent (UiO-FHD) which efficiently and selectively captures lead ions is developed by introducing multiple ligands. The maximum adsorption capacity of lead ions is 433.15 mg/g at pH 5. The adsorption process accords with the pseudo-second-order kinetic and the Langmuir isotherm models at room temperature. Thermodynamic experiments indicate that the removal of Pb(II) is facilitated by appropriate temperature reduction. The performance tests indicate that UiO-FHD maintains a high removal rate of 90.35% for Pb(II) after four consecutive adsorption–desorption cycles. The distribution coefficient of lead ions (26.7 L/g) shows that UiO-FHD has excellent selective adsorption for lead ions. It is revealed that the chelation of the sulfhydryl groups and the electrostatic interaction of the hydroxyl groups are the dominant factors to improve the removal rate of Pb(II) by density functional theory calculations. This study clarifies the value of self-designed novel organic ligands in metal–organic framework materials that selectively capture heavy-metal ions.

show abstract

Urine 2-hydroxyphenanthrene is associated with current asthma: evidence from NHANES 2007–2012

Mao

et al. 2023

Int Arch Occup Environ Health

View full text Add to dashboard Cite

Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases

Cited by 48 publications

References 65 publications

Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women

Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women

Design of Zr-MOFs by Introducing Multiple Ligands for Efficient and Selective Capturing of Pb(II) from Aqueous Solutions

Urine 2-hydroxyphenanthrene is associated with current asthma: evidence from NHANES 2007–2012

Contact Info

Product

Resources

About