Cadmium-induced ultrastructural changes in primary target organs of developing chicken embryos (Gallus domesticus)

Dżugan, Małgorzata; Trybus, Wojciech; Lis, Marcin; Wesołowska, Monika; Trybus, Ewa; Kopacz-Bednarska, Anna; Król, Teodora

doi:10.1016/j.jtemb.2018.06.015

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…In yeast, 1 mM CdCl 2 for 24 h inhibited cell growth but increased peroxisome number and catalase activity (Chen et al 1995). This was recently confirmed in developing chicken embryos where 2-8 µg cadmium/egg at E1, E14 or E18 showed peroxisomal extension and/or increased peroxisome number in glomerular cells, suggesting adaptive protection against cadmium-induced oxidative stress (Dzugan et al 2018). Yet, this interpretation may be too simple: Despite catalase's detoxifying function, oxidative stress has also been associated with peroxisome proliferation because H 2 O 2 -producing enzymes are augmented by > 10 times over the increase in H 2 O 2 -metabolizing enzymes (Rao and Reddy 1991) suggesting that cadmium-induced peroxisome proliferation may rather contribute to oxidative stress.…”

Section: Peroxisomesmentioning

confidence: 76%

Cell organelles as targets of mammalian cadmium toxicity

Lee

Thévenod

2020

Arch Toxicol

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Ever increasing environmental presence of cadmium as a consequence of industrial activities is considered a health hazard and is closely linked to deteriorating global health status. General animal and human cadmium exposure ranges from ingestion of foodstuffs sourced from heavily polluted hotspots and cigarette smoke to widespread contamination of air and water, including cadmium-containing microplastics found in household water. Cadmium is promiscuous in its effects and exerts numerous cellular perturbations based on direct interactions with macromolecules and its capacity to mimic or displace essential physiological ions, such as iron and zinc. Cell organelles use lipid membranes to form complex tightly-regulated, compartmentalized networks with specialized functions, which are fundamental to life. Interorganellar communication is crucial for orchestrating correct cell behavior, such as adaptive stress responses, and can be mediated by the release of signaling molecules, exchange of organelle contents, mechanical force generated through organelle shape changes or direct membrane contact sites. In this review, cadmium effects on organellar structure and function will be critically discussed with particular consideration to disruption of organelle physiology in vertebrates.

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Section: Peroxisomesmentioning

confidence: 76%

Cell organelles as targets of mammalian cadmium toxicity

Lee

Thévenod

2020

Arch Toxicol

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“…Williams et al (2017) reported that, after Pb contamination in birds, the weight and length of bird eggs were significantly decreased, whereas lesions to the liver, kidney, spleen, and thymus were increased [ 53 ]. In terms of Cd, the LD 50 of duck and chicken embryos was 8 μg, besides which they experienced a decrease in hatchability and hepatocyte damage [ 54 , 55 ]. The average concentrations of Cd in this study ranged between 8.94 and 13.13 μg kg −1 , which are also considered harmful levels to poultry in both areas.…”

Section: Resultsmentioning

confidence: 99%

Potential Health Effects of Heavy Metals and Carcinogenic Health Risk Estimation of Pb and Cd Contaminated Eggs from a Closed Gold Mine Area in Northern Thailand

Aendo

Garine-Wichatitsky

Mingkhwan

et al. 2022

Foods

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Gold-mining activities have been demonstrated to result in significant environmental pollution by Hg, Pb, and Mn, causing serious concerns regarding the potential threat to the public health of neighboring populations around the world. The present study focused on heavy-metal contamination in the eggs, blood, feed, soil, and drinking water on chicken farms, duck farms, and free-grazing duck farms located in areas < 25 km and > 25 km away from a gold mine in northern Thailand. In an area < 25 km away, Hg, Pb, and Mn concentrations in the eggs of free-grazing ducks were significantly higher than > 25 km away (p < 0.05). In blood, Hg concentration in free-grazing ducks was also significantly higher than those in an area > 25 km away (p < 0.05). Furthermore, the Pb concentration in the blood of farm ducks was significantly higher than in an area > 25 km away (p < 0.05). The concentration of Cd in drinking water on chicken farms was significantly higher for farms located within 25 km of the gold mine (p < 0.05). Furthermore, a high correlation was shown between the Pb (r2 = 0.84) and Cd (r2 = 0.42) found between drinking water and blood in free-grazing ducks in the area < 25 km away. Therefore, health risk from heavy-metal contamination was inevitably avoided in free-grazing activity near the gold mine. The incremental lifetime cancer risk (ILCR) in the population of both Pb and Cd exceeded the cancer limit (10−4) for all age groups in both areas, which was particularly high in the area < 25 km for chicken-egg consumption, especially among people aged 13–18 and 18–35 years old. Based on these findings, long-term surveillance regarding human and animal health risk must be strictly operated through food chains and an appropriate control plan for poultry businesses roaming around the gold mine.

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“…The avian embryo is an approved biological model which can be used to reflect environmental contamination under laboratory conditions (e.g., Liu et al, 2015 ; Dżugan et al, 2018 ; Bojarski et al, 2021 ). The aim of the current study was to assess the influence of embryonic exposure to cadmium (administrated as CdCl 2 × 2.5 H 2 O) on basic ( RBC – erythrocyte count, Ht – hematocrit value, and Hb – hemoglobin concentration) and derived ( MCV – mean corpuscular volume, MCH – mean corpuscular hemoglobin, and MCHC – mean corpuscular hemoglobin concentration) erythrocyte indices, the morphology and morphometric properties of erythrocytes, as well as erythrocyte spectrin distribution in newly hatched Gallus gallus domesticus chicks.…”

Section: Introductionmentioning

confidence: 99%