Cadmium-induced hepatotoxicity in three different rat strains

Expression of adhesion molecules during cadmium hepatotoxicity

“…Cd is one of the inflammation-related xenobiotics (Theocharis et al, 1994;Funkhouser et al, 1994;Horiguchi et al, 1993). In particular, Cd hepatotoxicity is closely related to inflammation, since after acute Cd exposure, the damaged liver tissues are often accompanied by infiltration of inflammatory cells, mainly neutrophils (Hoffmann et al, 1975;Hata et al, 1980;Dudley et al, 1982;Theocharis et al, 1991;Kayama et al, 1995).…”

Species differences in the renal toxicity of the antiarthritic drug, gold sodium thiomalate

“…Acute exposure to inorganic Cd produces liver toxicity (6), whereas chronic exposure to the metal causes renal damage, possibly due to uptake of CdMT released from the liver (7,8). Strain differences have been observed in Cd-induced hepatotoxicity in inbred rats, as measured by changes in serum enzymes (9). Previous studies have shown that susceptability to Cd-induced hepatic and testicular toxicities are markedly different in inbred strains of mice (10)(11)(12)(13)(14).…”

Effect of cadmium on liver regeneration after partial hepatectomy in rats.

“…In our study Cd was administered either prior or simultaneously to PH and the effect of Cd on 3HTdR incorporation and TK activity was examined at different time points up to 96 hr. Both administered doses were below the LD50 for ip injection of this toxic agent in rats (15) and no mortality was observed after its administration in different rat strains (20). Our results showed a marked inhibition of the deoxynucleotide-synthetizing enzyme TK and DNA synthesis in the liver of partially hepatectomized rats in the presence of Cd, at the time intervals of 0 up to 36 hr.…”