Cadmium-induced changes in the histoenzymatic activity in liver, kidney and duodenum of pregnant rats

Steibert, E; Król, B.; Sowa, Bogusław; Gralewska, Krystyna; Kamiński, Marian; Kamińska, Olga; Kúsz, Erzsébet

doi:10.1016/0378-4274(84)90136-x

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…Adverse effects of cadmium on iron, copper and zinc metabolism had been reported (Ammerman et al, 1977). Reduced copper content in fetal liver, placenta and fetal intestine were also found in rats after gestational exposure to oral cadmium (50 µg/ml Cd in drinking water) (Steibert et al, 1984;Sowa et al, 1985). However, in our study, cadmium induced increase of copper content in tissues.…”

Section: Iron Copper and Zinc Retention In Tissuescontrasting

confidence: 48%

Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Han¹,

Xu²,

Wang³

et al. 2004

Asian Australas. J. Anim. Sci

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This experiment was conducted to investigate the effect of cadmium levels on weight gain, nutrient digestibility and the retention of iron, copper and zinc in tissues of growing pigs. A total of one hundred and ninety-two crossbred pigs (barrows, Duroc×Landrace×Yorkshine, 27.67±1.33 kg of average initial body weight) were randomly allotted to four treatments. Each treatment had three replicates with 16 pigs per pen. The corn-soybean basal diets were supplemented with 0, 0.5, 5.0, 10.0 mg/kg cadmium respectively, and the feeding experiment lasted for eight-three days. Cadmium chloride was used as cadmium source. The results showed that pigs fed the diet containing 10.0 mg/kg cadmium had lower ADG and FCR than any other treatments (p<0.05). Apparent digestibility of protein in 10.0 mg/kg cadmium-treated group was lower than that of other groups (p<0.05). There was lower iron retention in some tissues of 5.0 mg/kg and 10.0 mg/kg cadmium treatments (p<0.05). However, pigs fed the diet 10.0 mg/kg cadmium had higher copper content in most tissues than that of any other groups (p<0.05). There was a significantly increase of zinc retention in kidney of 10.0 mg/kg cadmium additional group (p<0.05) and zinc concentrations in lymphaden, pancreas and heart of 10.0 mg/kg cadmium treatment were lower than those of the control (p<0.05). This study indicated that relatively high cadmium level (10.0 mg/kg) could decrease pig growth performance and change the retention of iron, copper and zinc in most tissues during extended cadmium exposure period.

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Section: Iron Copper and Zinc Retention In Tissuescontrasting

confidence: 48%

Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Han¹,

Xu²,

Wang³

et al. 2004

Asian Australas. J. Anim. Sci

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show abstract

“…Seriously depleted hepatic duodenal and renal stores of zinc, copper, and iron would be expected to exert an indirect mechanism on the maternal-fetal transfer of nutrients, as reflected by fetal growth retardation (Steibert et al, 1984). It should be emphasized that in the current study a direct correlation between the diminished Cp activity in serum of the female rats exposed to cadmium and the reduction of Cu and Fe in fetal liver was found.…”

Section: Figmentioning

confidence: 85%

“…Gestational exposure to oral cadmium resulted in decreased zinc, copper, iron, and metallothionein (MT) content in fetal liver as well as in reduced copper content in the placenta and fetal intestine (Sowa et al, 1982;Steibert et al, 1984;Sowa and Steibert, 1985).…”

Section: Introductionmentioning

confidence: 99%

Cadmium Interaction with Essential Metals (Zn, Cu, Fe), Metabolism Metallothionein, and Ceruloplasmin in Pregnant Rats and Fetuses

Chmielnicka

Sowa

1996

Ecotoxicology and Environmental Safety

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“…Total uptake of Cu from ceruloplasmin was seven times greater than that from albumin for the placental, whole fetuses, and fetal liver (Steibert et al, 1984). The authors also conclude that Cu destined for the fetus is delivered mainly or exclusively by ceruloplasmin.…”

Section: Discussionmentioning

confidence: 88%

Variations in Metallothionein, Zn, Cu, and Fe Concentrations and Ceruloplasmin Activity in Pregnant Rat Dams and Their Fetuses

Chmielnicka

Sowa

2000

Ecotoxicology and Environmental Safety

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Cadmium-induced changes in the histoenzymatic activity in liver, kidney and duodenum of pregnant rats

Cited by 10 publications

References 9 publications

Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Cadmium Interaction with Essential Metals (Zn, Cu, Fe), Metabolism Metallothionein, and Ceruloplasmin in Pregnant Rats and Fetuses

Variations in Metallothionein, Zn, Cu, and Fe Concentrations and Ceruloplasmin Activity in Pregnant Rat Dams and Their Fetuses

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