Cadmium induced cerebral toxicity via modulating MTF1-MTs regulatory axis

Talukder, Milton; Bi, Shao-Shuai; Jin, Hong; Ge, Jing; Zhang, Cong; Lv, Mei-Wei; Li, Jinlong

doi:10.1016/j.envpol.2021.117083

Cited by 44 publications

(26 citation statements)

References 106 publications

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“…6 Some environmental factors are able to disarrange the homeostasis of the thymus, leading to immunodeficiency. 12,33 ATZ, used as a herbicide to control broad-leaved and grassy weeds for decades, has been recognized as a health risk factor. 34 However, ATZ is still employed as an herbicide in numerous countries.…”

Section: Discussionmentioning

confidence: 99%

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Zhu

Tong

et al. 2022

Food Funct.

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Section: Discussionmentioning

confidence: 99%

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Zhu

Tong

et al. 2022

Food Funct.

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“…Besides, MT1 and MT2 expressions were induced in liver and lung cells even upon low-dose Cd exposure (Shen et al 2019 ). It has been reported that MTF1 is a molecular target of Cd-induced cerebral toxicity (Talukder et al 2021 ). Thus, MTF1 and MTs are involved in Cd toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…This study detected the MDA, H 2 O 2 , T-AOC, T-SOD, CAT, and GSH-PX according to the manufacture’s instruction; the optimal operating conditions were described by Zhao and Talukder et al (Talukder et al 2021 ; Zhao et al 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Cadmium Through Disturbing MTF1-Mediated Metal Response Induced Cerebellar Injury

Talukder

Jin³

et al. 2022

Neurotox Res

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“…Electron microscopy was performed as previously described. , In brief, small pieces of the cerebrum (nearly 1 mm 3 ) were fixed with glutaraldehyde for 3 h at 4 °C. After 3 h, these pieces were again washed in glutaraldehyde and then prepared with osmium tetroxide in sodium phosphate buffer.…”

Section: Methodsmentioning

confidence: 99%

Gap Junction Protein Connexin 43 as a Target Is Internalized in Astrocyte Neurotoxicity Caused by Di-(2-ethylhexyl) Phthalate

Zhao

Tang

Sun

et al. 2022

J. Agric. Food Chem.

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phthalate (DEHP) is widely used as a plasticizer in plastic products, consumer products, and packaging materials. It is of great health concern in both animals and humans as it released into the environment and entered into the body from plastic products over time, thereby resulting in neurotoxicity. As a pivotal regulator of the central nervous system (CNS), astrocytes, are crucial for maintaining brain homeostasis. Nevertheless, the underlying reason for astrocyte neurotoxicity due to DEHP exposure remains incompletely understood. Here, using an in vivo model of neurotoxicity in quail, this study summarizes that Cx43 is internalized by phosphorylation and translocated to the nucleus as a consequence of DEHP exposure in astrocytes. This study further demonstrated that astrocytes transformed to pro-inflammatory status and induced the formation of autophagosomes. Of note, integrated immunofluorescent codetection approaches revealed an overexpression of the glial fibrillary acidic protein (GFAP) and down-expression of Cx43 in astrocytes. Therefore, in terms of neurotoxicity, this experiment in vivo models directly linked Cx43 internalization to autophagy and neuroinflammation and ultimately locked these changes to the astrocytes of the brain. These findings unveil a potential approach targeting Cx43 internalization for the treatment of neurodegeneration caused by DEHP exposure in astrocytes.

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Cadmium induced cerebral toxicity via modulating MTF1-MTs regulatory axis

Cited by 44 publications

References 106 publications

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk

Cadmium Through Disturbing MTF1-Mediated Metal Response Induced Cerebellar Injury

Gap Junction Protein Connexin 43 as a Target Is Internalized in Astrocyte Neurotoxicity Caused by Di-(2-ethylhexyl) Phthalate

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