Cadmium in food: Source, distribution and removal

Wang, Ruoyu; Sang, Panting; Guo, Yahui; Jin, Peng; Cheng, Yuliang; Yu, Hang; Xie, Yunfei; Yao, Weirong; Qian, He

doi:10.1016/j.foodchem.2022.134666

Cited by 71 publications

(38 citation statements)

References 104 publications

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“…The main exposure route of Cd is the oral ingestion of contaminated foods and water. Besides, inhalation of contaminated air/cigarette smoking is another important exposure way (2).…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

İlhan

Büyükbayram

2023

SDÜ Tıp Fakültesi Dergisi

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Objective Cadmium (Cd) is a very toxic and carcinogenic heavy metal that can cause harmful effects on human health. Toxicity may develop due to Cd exposure, especially in the kidneys. Ankaferd blood stopper (ABS) is a herbal mix that is used for its hemostatic properties in surgery. Also, ABS enhances wound and tissue healing. In this study, we aimed to evaluate the possible ameliorative effects of ABS in Cd-induced renal damage. Material and Methods Thirty-two male rats were randomly divided into 4 groups: control, Cd (cadmium chloride, 2.5 mg/kg single dose, i.p.), ABS (ABS, 1.5 ml/kg single dose i.p.), and Cd+ABS (cadmium chloride, 2.5 mg/kg single dose i.p.- ABS, 1.5 ml/kg single dose i.p.). At the end of the experiment, urea and creatinine levels were analyzed from the rats’ serum. In addition, total oxidant status (TOS), total antioxidant status (TAS) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were measured spectrophotometrically from renal tissues. The oxidative stress index (OSI) was calculated from TOS and TAS levels. Also, we evaluated alterations in the mRNA expression of Bcl-2-associated X protein (Bax), B-cell-lymphoma-2 (Bcl-2), silenced information regulator 1 (SIRT1), and p53 in kidney tissue of rats by using the qRT-PCR method. Results In the Cd group, serum urea, creatinine levels, and tissue oxidative stress markers, TOS and OSI were higher while Gpx activity was significantly lower than in the control group. Also, the expression of p53 and in Bax/Bcl2 ratio increased in the Cd group. But, ABS treatment diminished urea, creatinine, TOS, OSI levels, and Bax/Bcl2 ratio, p53 expression in Cd applied group. Conclusion ABS showed protective effects by reducing oxidative stress and mitochondria-mediated apoptosis in acute Cd exposure.

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“…The main exposure route of Cd is the oral ingestion of contaminated foods and water. Besides, inhalation of contaminated air/cigarette smoking is another important exposure way (2).…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

İlhan

Büyükbayram

2023

SDÜ Tıp Fakültesi Dergisi

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“…Cadmium is a common chemical pollutant, which mainly enters the soil and water environment through the discharge of industrial wastewater and the deposition of cadmium-containing particles into the atmosphere. 1 Divalent ions are its main form. Once Cd 2+ enters the soil, it can gradually accumulate and endanger the soil and crops, and further endanger animal and human beings through transmission through the food chain.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of pH influence on aptamer binding with Cd²⁺ revealed by molecular dynamics simulation

Yuan

Ren

et al. 2023

New J. Chem.

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“…Cadmium (Cd), a very common toxicant, people are mainly exposed to it mainly derived from polluted water and air due to the industrial production or smoking 1,2 . Since it does not degrade in living organisms, and is slowly metabolized, 3 Cd can causes considerable damage to organs, such as renal, liver, bone and especially nerves 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Cadmium‐induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH‐SY5Y cells

Shi

Wang

et al. 2023

Environmental Toxicology

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Cadmium (Cd) is a hypertoxic heavy metal that may be exposed to environmental pollutants by humans and animals. It can lead to cognitive disfunction, and is linked to neurodegenerative diseases. Cadmium reportedly can induce endoplasmic reticulum (ER) stress, but few studies have concentrated on it in nerve cells, and the connection between ER stress and neuroinflammation. In this study, in vitro experiments on SH‐SY5Y neuroblastoma cells were carried out. We aimed at exploring whether Cd attributed to the cell pyroptosis and the role of PERK in promoting this form of cell damage which can induce strong inflammatory responses. Our results demonstrated that CdCl2 treatment induced excess reactive oxygen species (ROS) production, caused significant modifications in the expression of PERK and increased TXNIP, NLRP3, IL‐1β, IL‐18, and caspase1 in SH‐SY5Y cells. In addition, scavenging ROS with N‐acetylcysteine or inhibiting the expression of PERK by using GSK2606414, rescued the SH‐SY5Y cells from cadmium‐induced pyroptosis. In conclusion, the results suggest that Cd induces pyroptotic death of SH‐SY5Y cells through ER stress, and this may be the potential mechanism of Cd incurring neurological diseases.

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Cadmium in food: Source, distribution and removal

Cited by 71 publications

References 104 publications

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

Mechanism of pH influence on aptamer binding with Cd²⁺ revealed by molecular dynamics simulation

Cadmium‐induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH‐SY5Y cells

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Cadmium in food: Source, distribution and removal

Cited by 71 publications

References 104 publications

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

Mechanism of pH influence on aptamer binding with Cd2+ revealed by molecular dynamics simulation

Cadmium‐induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH‐SY5Y cells

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Mechanism of pH influence on aptamer binding with Cd²⁺ revealed by molecular dynamics simulation