Cadmium disposition and metallothionein induction in mice: strain-, sex-, age-, and dose-dependent differences

Reactivation of herpes simplex virus from latently infected mice after administration of cadmium is mouse-strain-dependent

“…This difference in response did not correlate with relative susceptibility to HSVi infection observed in this study, which was high for strain A, moderate for CBA and C3H/He strains and low for BALB/c and C5 7BL/6 strains. Cd-induced reactivation did not coincide with Cd mortality in this study, and also did not match any previously reported strain-dependent responses to Cd, such as tissue deposition (Maitani & Suzuki, 1986;Shaikh et aI., 1993), relative nephro-or hepato-sensitivity (Maitani & Suzuki, 1986), immunotoxicity (Quaife et al, 1993) or production of metallothioneins (Nolan & Shaikh, 1986;Shaikh et al, 1993). Nor was there any apparent correlation with the rnajor H-2 loci of these five mouse strains, since CBA and C3H/He mice (the latter did not reactivate virus) share the same H-2 haplotype, which differs from that of strain A mice at several H-2 loci.…”

“…The markedly high Cd mortality of A mice in this study was likely a result of the higher cumulative body burden of Cd in this study; 74 gmol Cd/kg body weight over 3 days, as compared to 30 gmol Cd/kg body weight over I day (Maitani & Suzuki, 1986;Shaikh et at., 1993). No mortality followed Cd treatment of CdH/He mice, although this strain had been reported to be most hepatosensitive to Cd (Hata et al, 1980;Maitani & Suzuki, 1986;Nolan & Shaikh, i986;Quaife et al, 1986;Tsunoo et aI., 1979).…”

Wistar-Imamichi Rats Exhibit a Strong Resistance to Cadmium Toxicity.

“…Acute Cd toxicity is also manifested in the liver and kidney of mice, again with a difference among strains. 10) In rats, information on strain differences in Cd toxicity has been limited. Cd is a potent cell poison known to cause oxidative stress by increasing lipid peroxidation and by changing intracellular glutathione levels.…”

Classical Conditioning of Metallothionein Synthesis in Mice

“…5,14) MT levels induced by stress are different between strains of animals. 16,17) To elucidate the MT synthesis induced by psychological stress, we examined whether MT synthesis in ICR and C57BL mice can be conditioned by exposure of the mice to the odor of camphor according to the procedure described in Table 1. Only exposure to the odor of camphor did not induce MT synthesis in this experimental conditions (data not shown).…”