Cadmium content of indicator and target organs in rats after graded doses of cadmium

Cadmium content of indicators and target organs after acute Cd exposure

“…12 In this study, where the rats were exposed to Cd in a situation similar to acute exposure, molars reflected the Cd content of all target organs except epis and muscle, while hair reflected the Cd contents of epis, dias, kidney cortex, liver and spleen (see Table V). Blood and incisors were not suitable as indicators of acute Cd exposure.…”

“…In addition, the incisors as well as the molars of the left half of the upper and lower jaws were pooled for each group, and the enamel and the dentin of each pooled sample were separated. 12 The soft tissues, hair and blood were treated according to the method of Wesenberg et al 12 To obtain sufficient material of the tissues of the three weeks old animals (8E-11C, see Table I) some small modifications were necessary. The right femur of each animal was not separated into epi and dia, but analyzed in toto.…”

“…12 The Cd concentrations were measured by a Perkin Elmer 370A atomic absorption spectrophotometer by means of direct aspiration or the sampling boat technique, depending on the concentrations of Cd in the solutions. The 228.8 nm absorption line was used.…”

“…12 In that study the Cd content of easily accessible indicators, as hair and blood, was correlated with the dose of Cd and to the Cd concentrations of target organs, i.e. soft tissues and bone.…”

“…14 Deciduous teeth are easily available from dental clinics in schools. As it has been shown that rat molars are suitable indicators of chronic exposure, 12 it was of interest to investigate whether the Cd content of rat molars can also be used as an indicator of past Cd exposure in rats.…”