Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa; Jagodić, Jovana; Borković-Mitić, Slavica; Paunović, Ivan; Živaljević, Vladan; Mitić, Bojan M.; Gavrović-Jankulović, Marija; Manojlović, Dragan

doi:10.1016/j.jtemb.2019.06.009

Cited by 26 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, the investigated CTs contained significantly elevated Se levels. These results are very interesting, considering that our previous study highlighted the deficiency of Se in the thyroid tissue of the Serbian population 25 . Furthermore, in the current study, the Se concentrations in analyzed liquid clinical samples of MBT patients were significantly lower than in the CGs, which could signify the sequestration of Se into the malignant brain cells for the stimulation of cancer growth.…”

Section: Discussionsupporting

confidence: 59%

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex-and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis. The importance of trace metals in the neurosciences has become more compelling during the first decade of the 21 st century 1 , as there is considerable interest in finding the relationships between trace metals and various neurological diseases, including central nervous system (CNS) malignancies. Metals show their harmful effects at the first stage of cancerogenesis (initiation) 2. Initiation can affect normal biochemical reactions, leading to alterations in metal profiles. Considering that trace metals play a significant role in neoplastic processes, the metal contents in neoplastic samples can differ from the composition in control ones 3. Homeostasis of metals within tight physiological limits is maintained through the mechanisms of uptake, distribution, accumulation, and secretion. Each breakdown has deleterious effects on metal-regulated metabolic pathways and can be a crucial step in the pathogenesis of various diseases. The most important pathway in metal-induced cancerogenesis is the ability of a metal to modulate gene expression by interfering with signal transduction pathways, leading to the deregulation of cell proliferation, activation of numerous transcription factors, disruption of cell cycle course, and apoptosis 4. Metal homeostasis is critical for the proper functioning of the brain 5. The brain is a target organ for toxic environmental pollutants 6. The balance of metals within the brain is regulated through the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier. In physiological conditions, these barriers regulate CNS homeostasis

show abstract

Section: Discussionsupporting

confidence: 59%

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Long-term exposure to Cd has been associated with various conditions, including various renal syndromes, osteoporosis and osteomalacia, CVD, and different types of cancer [14,15,[19][20][21][22][23][24][25]. Its endocrine-disrupting properties have also been shown, suggesting its possible effects on estrogenic activity [26][27][28][29], alterations in semen and the testis [30][31][32], and a role in thyroid disorders [33][34][35]. The mode of toxic Cd actions in the organism have been extensively investigated, but still not entirely elucidated, mainly because they may change with the dose and the detailed health status of the exposed subjects.…”

Section: Introductionmentioning

confidence: 99%

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Buha

Đukić-Ćosić

Ćurčić

et al. 2020

Toxics

View full text Add to dashboard Cite

Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.

show abstract

“…BPA and di-(2-ethylhexyl) phthalate (DEHP) would be related to the occurrence of Hashimoto’s thyroiditis and thyroid cancer ( 79 ). Increased risk of papillary thyroid carcinoma was also observed after the human exposure to polybrominated diphenyl ethers ( 80 ), flame retardants [BDE-209 and tris (2-chloro-ethyl) phosphate (TCEP)] ( 81 ) and cadmium ( 82 ).…”

Section: Glyphosate Toxicity In Hpt Axismentioning

confidence: 99%

Could Glyphosate and Glyphosate-Based Herbicides Be Associated With Increased Thyroid Diseases Worldwide?

Romano

Oliveira

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

The increased incidence of thyroid diseases raises a series of questions about what the main predisposing factors are nowadays. If dietary restriction of iodine was once a major global health concern, today, the processes of industrialization of food and high exposure to a wide variety of environmental chemicals may be affecting, directly or indirectly, thyroid function. The homeostasis of hypothalamus–pituitary–thyroid (HPT) axis is finely regulated through the negative feedback mechanism exerted by thyroid hormones. Allostatic mechanisms are triggered to adjust the physiology of HPT axis in chronic conditions. Glyphosate and glyphosate-based herbicides are pesticides with controversial endocrine disrupting activities and only few studies have approached their effects on HPT axis and thyroid function. However, glyphosate has an electrophilic and nucleophilic zwitterion chemical structure that may affect the mechanisms involved in iodide oxidation and organification, as well as the oxidative phosphorylation in the ATP synthesis. Thus, in this review, we aimed to: (1) discuss the critical points in the regulation of HPT axis and thyroid hormones levels balance, which may be susceptible to the toxic action of glyphosate and glyphosate-based herbicides, correlating the molecular mechanisms involved in glyphosate toxicity described in the literature that may, directly or indirectly, be associated to the higher incidence of thyroid diseases; and (2) present the literature regarding glyphosate toxicity in HPT axis.

show abstract

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

Cited by 26 publications

References 35 publications

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Could Glyphosate and Glyphosate-Based Herbicides Be Associated With Increased Thyroid Diseases Worldwide?

Contact Info

Product

Resources

About