Cadmium as an Endocrine Disruptor in the Reproductive System

Chedrese, P. Jorge; Piasek, Martina; Henson, Michael C.

doi:10.2174/187152206775528941

Cited by 36 publications

(46 citation statements)

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“…Cadmium, mercury, lead, and arsenic are suspected to affect the endocrine system (58)(59). Evidence is usually limited to animal data or to in vitro studies (59)(60)(61).…”

Section: Targets and Mechanisms Of Metal Actionmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

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A combination of genetic, environmental and lifestyle factors contributes to adverse effects on the reproductive health in men. Metals are pervasive in food, water, air, tobacco smoke, and alcoholic beverages. Experimental studies suggest that many metals have adverse effects on the male reproductive function. However, information about reproductive effects of human exposure to metals is scarce and/or inconsistent. This review summarises the information from epidemiological studies of the effects of metal exposure on reproductive function in men. Factors capable of affecting these relationships were identifi ed and discussed. A particular attention is given to the studies considering infl uence of concomitant exposure to various metals. These studies have generally confi rmed that even moderate-to low-level exposure to lead affects certain reproductive parameters, and that exposure to cadmium affects the prostate function and serum testosterone levels. Adverse effects of mercury, manganese, chromium and arsenic on semen quality and altered serum hormone are less well documented. There is no clear evidence that boron exposure may impair reproductive health in men. Only a few studies have investigated reproductive effects of concomitant exposure to several metals and controlled for potential confounders. Future studies should consider the contribution of combined exposure to various metals and/or other factors that may infl uence individual susceptibility to reproductive health impairment in men. KEY WORDS: human semen quality, metals, metalloids, metal interactions, sex hormonesPizent A, et al.

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“…Cadmium, mercury, lead, and arsenic are suspected to affect the endocrine system (58)(59). Evidence is usually limited to animal data or to in vitro studies (59)(60)(61).…”

Section: Targets and Mechanisms Of Metal Actionmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

View full text Add to dashboard Cite

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“…There is emerging information concerning the role of cadmium as an endocrine disruptor in the placenta and the mechanism(s) involved (Bush et al, 2000;Henson and Chedrese, 2004;Myllynen et al, 2005;Chedrese et al, 2006;Yang et al, 2006). Indirect health e ects caused by cadmium accumulation in the placenta can involve altered placental function(s) such as changes in placental hormone production and transplacental nutrient passage of essential trace elements.…”

Section: Cadmium and Human Placentamentioning

confidence: 99%

“…To this end, it is well known that cadmium accumulates in human placenta with advancing gestation and may disrupt the synthesis and or release of hormones produced by the trophoblast (Piasek et al, 2001(Piasek et al, , 2002(Piasek et al, , 2007Henson and Chedrese, 2004;Chedrese et al, 2006). These hormones include steroids such as progesterone, which is necessary for the maintenance of pregnancy by preserving uterine myometrial quiescence, testosterone and estrogen.…”

Section: Mechanisms Of Cadmium-related Placental Effectsmentioning

confidence: 99%

“…These metallic elements and compounds, many of which also function as metalloestrogens, include arsenic, cadmium, lead, mercury and uranium (Abu-Qare and Abou-Donia, 2002;Choe et al, 2003;Chedrese et al, 2006;Takiguchi and Yoshihara, 2006;Dyer, 2007;Davey et al, 2008;Henson et al, 2010). They can be classi ed as endocrine disruptors because they have the potential to mimic or block endogenous steroid hormones in a number of wildlife species, as well as in many mammals, including humans, by interacting with hormone receptors (McLachlan, 2001;Guillette, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin

Stasenko

Bradford

Piasek

et al. 2009

J of Applied Toxicology

Self Cite

105

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Cadmium and other metallic ions can act as metalloestrogens and endocrine disruptors of reproductive tissues and fetal development in mammals, including humans. The detrimental effects occur with respect to the synthesis of both steroid and polypeptide hormones in the placenta. Leptin is produced by the trophoblast and may regulate fetal organogenesis and development. In human term placentas, concentrations of toxic metals and their effects on steroidogenesis were assessed in healthy parturients (109 non-smokers and 99 smokers) in relation to tobacco smoking. Trace elements (cadmium, lead, iron, zinc and copper) were analyzed in placentas using atomic absorption spectroscopy, and steroid hormones (progesterone and estradiol) were assayed in placental samples by an enzyme-immunometric method. Cadmium concentrations were doubled in placentas of smokers as compared with non-smokers, and placental lead and zinc concentrations increased significantly. Placental concentrations of iron, copper, progesterone and estradiol did not differ. In addition, human trophoblast cells were co-cultured with 0, 5, 10 or 20 microm CdCl(2) for 96 h and leptin mRNA assessed by quantitative polymerase chain reaction. Leptin mRNA declined dose-responsively as a result of CdCl(2) exposure. Collectively, the results confirm that human placental tissue offers a unique opportunity to biomonitor cadmium exposure in both the maternal and the internal fetal environments. In addition, the results strongly suggest that cadmium may cause a decline in placental leptin synthesis, as we have previously shown for placental progesterone production. This may constitute further evidence of the endocrine-disrupting effects of cadmium, as a constituent of tobacco smoke, on reproduction in women.

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“…In addition the reaction solvent is ethylene glycol, which can form unstable polymers that break down in a strongly exothermic reaction, raising the reactor temperature and pressure uncontrollably, with the synthesis of substantial amounts of dioxin, occasionally even blowing the safety valves (Schecter et al, 2006). Both organic and inorganic mercury is used in the production of fungicides and this metal is well known to be neurotoxic and endocrine disrupter (Tan et al, 2009); cadmium is a frequent impurity in many phosphorus-based fertilizers and its presence could produce much more effects on endocrine system owing to its own ability to interfere as xenoestrogen (Chedrese et al, 2006;Takiguchi & Yoshihara, 2006).…”

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confidence: 99%