Cadmium and other elements in tissues from four ungulate species from the Mackenzie Mountain region of the Northwest Territories, Canada

Larter, Nicholas C.; Macdonald, C.R.; Elkin, Brett; Wang, X.; Harms, N. Jane; Gamberg, Mary; Muir, Derek C. G.

doi:10.1016/j.ecoenv.2016.05.018

Cited by 9 publications

(1 citation statement)

References 36 publications

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“…Specifically, the level of Cd in chicken and turkey meat from Southern Nigeria ranged from 0.01 to 5.68 mg/kg (Iwegbue et al, 2008), whereas Cd levels in goats bred in Nigeria were estimated to range between 0.34 and 0.83 mg/kg (Nwude et al, 2010; Okoye and Ugwu, 2010). Mean Cd concentrations were highest in moose (48.3 mg/kg) and least in mountain goats (5.78 mg/kg) consumed in the mountain region of Northwest Canada (Larter et al, 2016). The dietary intake of Cd from cow meat was greater in comparison to the provisional tolerable weekly intake.…”

Section: Introductionmentioning

confidence: 99%

Diethylnitrosamine aggravates cadmium-induced hepatorenal oxidative damage in prepubertal rats

2019

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The adverse health consequences of environmental, occupational, and dietary exposure to either diethylnitrosamine (DEN) or cadmium (Cd) have been widely investigated. However, because most environmental exposures to xenobiotics do not occur in isolation but in mixtures, the effects of simultaneous exposure to both DEN and Cd on hepatorenal function deserves investigation. The present study investigated the impact of 7 days oral co-exposure to 10 mg/kg body weight (b.w.) of DEN and 5 mg/kg b.w. of Cd on biomarkers of hepatic and renal functions, antioxidant defense systems, and oxidative stress indices in the liver and kidney of prepubertal rats. The results showed that the significant ( p < 0.05) increases in the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase, urea, and creatinine following separate administration of DEN and Cd to rats were further increased in the co-exposure group. Moreover, marked decreases in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase as well as glutathione levels following individual administration of DEN and Cd to rats were exacerbated in the co-exposure group. Further, the marked increase in the lipid peroxidation level and the histopathological lesions in the liver and kidney of rats treated with DEN or Cd alone were intensified in the co-exposure group These findings indicate that co-exposure to DEN and Cd elicited more severe hepatic and renal oxidative damage in the rats, thus suggesting a greater risk to humans who are co-exposed to them.

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Section: Introductionmentioning

confidence: 99%

Diethylnitrosamine aggravates cadmium-induced hepatorenal oxidative damage in prepubertal rats

2019

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Apex predatory mammals as bioindicator species in environmental monitoring of elements in Dinaric Alps (Croatia)

Lazarus

Sekovanić

Orct

et al. 2017

Environ Sci Pollut Res

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Tissue element investigations of apex terrestrial mammals are very scarce in Europe. We quantified 16 essential and nonessential elements in the kidney cortex, liver, and muscle tissue of 467 brown bears (Ursus arctos), 125 gray wolves (Canis lupus), one Eurasian lynx (Lynx lynx), and three golden jackals (Canis aureus) from Croatia by inductively coupled plasma mass spectrometry (ICP-MS). Renal cadmium (0.6% of animals) and lead (1%) and hepatic lead (5%) were found in toxicologically relevant levels for mammals only in bears, while the other elements were within normal range. The association of age, sex, season, and region with measured tissue elements in bear and wolf was estimated by multiple regression analyses. Age-related accumulation of cadmium was observed in bears and wolves. Lead tissue content increased with the age of bears but declined in wolves. Female bears and wolves had higher arsenic, iron, and thallium than males in some tissues. Also, cadmium, mercury, copper, zinc, selenium, molybdenum, and uranium were more abundant only in female bears. Male bears had higher potassium, zinc, and magnesium, while male wolves had higher calcium in some tissues compared to female wolves. Seasonal differences were mainly observed for bears' tissues and region-specific differences only in wolves. The bear kidneys had the highest levels of cobalt, copper, molybdenum, cadmium, and lead among the four studied species. The element levels reported for bears and wolves represent baseline values for the Dinaric population.

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Barbary sheep tissues as bioindicators of radionuclide and stabile element contamination in Croatia: exposure assessment for consumers

Lazarus

Gančević

Orct

et al. 2019

Environ Sci Pollut Res

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Cadmium and other elements in tissues from four ungulate species from the Mackenzie Mountain region of the Northwest Territories, Canada

Cited by 9 publications

References 36 publications

Diethylnitrosamine aggravates cadmium-induced hepatorenal oxidative damage in prepubertal rats

Diethylnitrosamine aggravates cadmium-induced hepatorenal oxidative damage in prepubertal rats

Apex predatory mammals as bioindicator species in environmental monitoring of elements in Dinaric Alps (Croatia)

Barbary sheep tissues as bioindicators of radionuclide and stabile element contamination in Croatia: exposure assessment for consumers

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