Cadmium and Lead in Women Who Miscarried

Omeljaniuk, Wioleta Justyna; Socha, Katarzyna; Soroczyńska, Jolanta; Charkiewicz, Angelika Edyta; Laudański, T; Kulikowski, M; Kobylec, Edward; Borawska, Maria H.

doi:10.7754/clin.lab.2017.170611

Cited by 38 publications

(40 citation statements)

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“…Lead's damage to the child can begin as early as pregnancy. Maternal lead can be passed through the placenta to the developing fetus [11,22]. The Pb content in the placenta is the result of many complex biochemical reactions and various factors related to the mother's body.…”

Section: Location Of Lead In the Bodymentioning

confidence: 99%

“…The susceptibility of the developing fetus to lead's adverse effects and the potential for preventing additional postnatal lead exposure justify intervention for pregnant women showing signs of exposure to lead [22]. When mothers blood lead concentrations are high, they should be encouraged to pump and eject milk until the level of lead in the blood drops below 40 μg/dl [23].…”

Section: Prevention and Monitoring Of Lead Poisoningmentioning

confidence: 99%

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The lead toxicity and pollution with this element in Poland

Charkiewicz

Backstrand²

2019

Preprint

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Background The aim of this review is to describe lead’s toxic effects on the human body from conception through adulthood.Results One toxic heavy metal is lead. Pb is very dangerous when it is absorbed and accumulates in the main organs of the body where it can cause a range of symptoms that vary from person to person, the time of exposure and dose. Lead in adults can cause an increase in blood pressure, slow nerve conduction, fatigue, mood swings, drowsiness, impaired concentration, fertility disorders, decreased sex drive, headaches, constipation and in severe cases encephalopathy or death.Conclusions Toxic exposure to lead in Poland remains an important public health problem. This review will cover the range of lead exposures, from mild to heavy. Public health interventions and policies also are needed to reduce occupational and environmental exposure to this heavy metal.

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Section: Location Of Lead In the Bodymentioning

confidence: 99%

Section: Prevention and Monitoring Of Lead Poisoningmentioning

confidence: 99%

The lead toxicity and pollution with this element in Poland

Charkiewicz

Backstrand²

2019

Preprint

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“…Animal studies have shown that toxic metals accumulate in selected organs and pass through the placental barrier to the fetus, causing teratogenic and embryotoxic effects in a wide variety of species . However, the evidence of metal toxicity in human embryos is deficient …”

Section: Introductionmentioning

confidence: 99%

Biomarkers of metal toxicity in embryos in the general population

Peng

Qiu

et al. 2019

Clinical Laboratory Analysis

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BackgroundWith the development of industrialization, public exposure to toxic metals could occur everywhere, eventually affecting individuals’ reproductive systems and even embryos and leading to early pregnancy loss. The aim of the study was to determine the profile of toxic metal levels in pregnant women in the general population and to identify biomarkers for metal toxicity in embryos.MethodsA case‐control study with pregnant women was conducted at Peking Union Medical College Hospital in 2016‐2018. Women who experienced spontaneous abortion within 12 weeks of gestation comprised the case group, and women with pregnancies showing fetal cardiac activity who requested an induced abortion almost simultaneously were included in the control group. Blood and urine specimen were tested for concentrations of cadmium, chromium, selenium, arsenic, and mercury.ResultsA total of 195 patients were enrolled, with 95 in the case group and 100 in the control group. Significant differences in gravidity, parity, history of miscarriage, mean blood cadmium levels, and mean urine chromium levels were present between the two groups (P1 = 0.013, P2 = 0.000, P3 = 0.000, P4 = 0.002, P5 = 0.046); the odds ratios in the spontaneous abortion with blood cadmium >0.4 µg/L, urine chromium >2 µg/L, gravity <3, parity <2, and history of miscarriage >1 compared with the induced abortion group were 1.26 (1.09, 1.85), 1.56 (1.23, 2.53), 1.39 (1.17, 1.98), 1.72 (1.21, 4.62), and 1.18 (1.06, 1.65), with P‐values of 0.003, 0.031, 0.003, 0.247, and 0.001, respectively.ConclusionBlood cadmium and urine chromium levels are two possible biomarkers of toxic metal embryotoxicity in the general population, which means that in the general population, blood cadmium >0.4 µg/L or urine chromium >2 µg/L might indicate an increased risk of spontaneous abortion.

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“…[30][31][32] There are numerous reports on the effects of these toxic metals on human health, especially during the gestation period of pregnant women. [33][34][35] Human TIP1 is involved in various signaling pathways controlling key biological processes including regulation of the cerebral concentration of neurotransmitter glutamate, β-catenin-mediated Wnt signaling, Rho-activator Rhotekin, and potassium channel Kir2.3 signaling pathway. 11,16,[24][25][26]36 Considering the importance of TIP1 for the well-being of a living cell, it is of great importance to investigate the effect of toxic metals on the structure of TIP1 and consequently on its function below levels that are currently allowed.…”

mentioning

confidence: 99%

“…30-32 There are numerous reports on the effects of these toxic metals on human health, especially during the gestation period of pregnant women. 33-35 Human TIP1 is involved in various signaling pathways controlling key biological processes including regulation of the cerebral concentration of neurotransmitter glutamate, β-catenin-mediated Wnt signaling, Rho-activator Rhotekin, and potassium channel Kir2.3 signaling pathway. 11,16,24-26,36…”

mentioning

confidence: 99%

Effect of Toxic Metal Binding on Tax-Interacting Protein1 (TIP1): A Protein Related to Brain Diseases

Chaudhary

Dahal

Sayania

et al. 2019

Natural Product Communications

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Human tax-interacting protein1 (TIP1), also known as glutaminase-interacting protein (GIP), is a small globular protein containing a PDZ domain. PDZ domains are the most common protein-protein interaction modules present in eukaryotes. In humans, TIP1 plays a very important role in many cellular pathways including β-catenin-mediated Wnt signaling, Rhoactivator rhotekin-mediated Rho signaling pathway, and glutamate signaling pathway for the normal activity of the central nervous system. TIP1 also regulates potassium channel expression in the plasma membrane and is a binding partner to many proteins including viral oncoproteins, HTLV-1 Tax and HPV16 E6. Since TIP1 is at a pivotal point in many cellular processes through its interaction with a growing list of partner proteins, any impact on the proper functioning of this protein can have severe consequences on the well-being of a living system. Although metals are essential for plants and animals in trace amounts, elevated levels of heavy metals such as arsenic, cadmium, zinc, and lead are toxic causing various health problems including cardiovascular disorders, neuronal damage, renal injuries, and cancer. Here, we report the effect of heavy metals, arsenic and cadmium, on TIP1 conformation using circular dichroism and fluorescence spectroscopy techniques. Our study revealed these metals have a significant impact on the structure of TIP1 even at very low levels.

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Cadmium and Lead in Women Who Miscarried

Cited by 38 publications

References 0 publications

The lead toxicity and pollution with this element in Poland

The lead toxicity and pollution with this element in Poland

Biomarkers of metal toxicity in embryos in the general population

Effect of Toxic Metal Binding on Tax-Interacting Protein1 (TIP1): A Protein Related to Brain Diseases

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