LTHOUGH LEAD TOXICITY IN humans has been recognized for centuries, the 20th century has left a legacy of unprecedented lead levels spread throughout the environment. Lead continues to pose a significant public health problem in spite of substantial reductions in lead exposure in the United States in the recent past. Moreover, exposure has not been totally eliminated and most adults continue to have substantial body burdens of lead. 1 Much of the lead taken into the body is incorporated into bone where it constantly interchanges with other tissues. 2 Recent studies suggest that accumulated lead exposure is related to several chronic disorders of aging including hypertension and cognitive decline, 1 disorders that have been associated with oxidative stress. 3,4 Several lines of evidence suggest that accumulated lead exposure could also increase the risk of another oxidative-stress-related disorder of aging, age-related cataractthe leading cause of blindness and visual impairment worldwide. 5 In the present study, the first we are aware of to investigate this hypothesis, we tested whether bone lead levels measured in both the tibia and patella were associated with age-related cataract in an ongoing study of men from the United States who were drawn from the general population surrounding Boston. METHODS Participants were drawn from the Normative Aging Study (NAS), a longitudinal study of 2280 healthy male volunteers, begun in Boston in the 1960s. 6 At the time of their initial enrollment, all NAS participants were free of heart disease, hypertension, diabetes mellitus, cancer, peptic ulcer, gout, recurrent asthma, bronchitis, or sinusitis. Study participants were predominantly white, and ranged in age from 48 to 93 years at the time of bone lead measurement. Every 3 to 5 years, participants underwent an extensive physical examination that Author Affiliations are listed at the end of this article.