Cadmium accumulation and toxicity in the kidney of the bay scallop Argopecten irradians

Carmichael, Neil G.; Fowler, Bruce A.

doi:10.1007/bf00397065

Cited by 42 publications

(22 citation statements)

References 15 publications

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“…In a number of invertebrate species (7,(20)(21)(22)(23)(24)(25)(26)(27), mineral concretions (Fig. 4) composed primarily of calcium phosphate appear to be extremely important in the intracellular handling of both essential and toxic metals.…”

Section: Mineral Concretionsmentioning

confidence: 99%

“…High-affinity metalbinding proteins (1)(2)(3)(4)(5)(6)(7), lysosomes (8)(9)(10)(11)(12), and precipitates such as inclusion bodies (13)(14)(15)(16)(17)(18)(19) or mineral concretions (7,(20)(21)(22)(23)(24)(25)(26)(27) all play important roles in intracellular metal homeostasis. The extent to which any one of these compartments is involved in metal binding appears to depend upon a number of factors, including dosing regimen for the metal administered, interactions with competing metals, cell type, organ, species, and life cycle.…”

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confidence: 99%

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Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury

Fowler¹

1987

Environmental Health Perspectives

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The intracellular compartmentation of essential and toxic metals is of intense scientific interest because of its potential for adding to our understanding of both normal homeostatic mechanisms for metals and of the mechanisms which underlie metal-induced cell injury. High-affinity metal-binding proteins, lysosomes, and precipitates such as inclusion bodies or concretions, play major roles in the regulation of divalent-metal cation bioavailability. The contribution of a given compartment toward metal homeostasis is dependent upon the level exposure, cell type, organ, species, and life cycle of the organism. Toxic metals may move between these compartments, but the rates and determinants of such exchanges have not been characterized. Available data clearly indicate that sequestration of toxic metals in these specialized compartments can produce profound disturbances in the subcellular handling of essential metals. Further studies of the mechanisms by which metals partition and/or transfer among these compartments are essential to understand and predict toxicity of this important class of toxic agents.Recent studies from a number of laboratories have identified several subcellular compartments as being major "sinks" for both essential and toxic metals in mammals and aquatic organisms. High-affinity metalbinding proteins (1-7), lysosomes (8-12), and precipitates such as inclusion bodies (13-19) or mineral concretions (7,(20)(21)(22)(23)(24)(25)(26)(27) all play important roles in intracellular metal homeostasis. The extent to which any one of these compartments is involved in metal binding appears to depend upon a number of factors, including dosing regimen for the metal administered, interactions with competing metals, cell type, organ, species, and life cycle. In addition, there appears to be movement of metals between these compartments, but the rates of metal exchange have not been determined. This review will focus on current knowledge of metal handling by these compartments, and the relationships that appear to exist between intracellular metal binding and toxicity in both mammals and nonmammalian aquatic species. This discussion will also attempt to suggest some needed areas for future research.It is hoped that this examination will illustrate the scientific potential of the comparative approach to provide a better understanding of mechanisms of metalinduced cell injury. In particular, attention will be focused on the relationships that must exist between intracellular compartmentation of metals and their bio- logical activity since this area appears to be of central importance to understanding mechanisms of injury under chronic exposure conditions. Metal-Binding ProteinsIn recent years, extensive attention has been focused on the roles of soluble metal-binding proteins in the biological acitivity of both essential and toxic metals in mammalian (1-6,10,11) and nonmammalian (6,(28)(29)(30) organisms. While a majority of these proteins appear to share similarities with mammalian metallothionein (2,31), others ...

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Section: Mineral Concretionsmentioning

confidence: 99%

mentioning

confidence: 99%

Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury

Fowler¹

1987

Environmental Health Perspectives

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“…Moreover, some experiments showed that a significant portion of the Cd content may be bound in membranes or accumulated in intracellular granules (Carmichael and Fowler, 1981;Metal-binding . .…”

Section: Discussionmentioning

confidence: 99%

“…The ability of various species of Pectinidae to accumulate large amounts of heavy metals in nature and under laboratory conditions is well-documented (Brooks and Rumsby, 1965;Bryan, 1973;Nelson et al, 1976;Saenko et al, 1976;Pesch and Stewart, 1980;Carmichael and Fowler, 1981); however, there is little information on biochemical mechanisms of detoxication of trace elements in molluscs.…”

Section: Introductionmentioning

confidence: 99%

Biochemical changes in selected body tissues of the scallop Patinopecten yessoensis under long-term exposure to low Cd concentrations

Evtushenko¹,

Lukyanova²,

Христофорова³

1984

Mar. Ecol. Prog. Ser.

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“…The characterization of the form of cadmium in the oysters is essential for interpreting the results of the epidemiological study. There have been several reports on the form of cadmium in shellfish (13)(14)(15)(16)(17). However, most of these studies have been performed after exposure of collected shellfish to different concentrations of cadmium.…”

Section: Introductionmentioning

confidence: 99%

Characterization Studies on the Cadmium-Binding Proteins from Two Species of New Zealand Oysters

Nordberg¹,

Nuottaniemi²,

Cherian³

et al. 1986

Environmental Health Perspectives

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Cadmium accumulation and toxicity in the kidney of the bay scallop Argopecten irradians

Cited by 42 publications

References 15 publications

Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury

Intracellular Compartmentation of Metals in Aquatic Organisms: Roles in Mechanisms of Cell Injury

Biochemical changes in selected body tissues of the scallop Patinopecten yessoensis under long-term exposure to low Cd concentrations

Characterization Studies on the Cadmium-Binding Proteins from Two Species of New Zealand Oysters

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