Cadherin Trafficking for Tissue Morphogenesis: Control and Consequences

West, Junior J.; Harris, Tony

doi:10.1111/tra.12407

Cited by 43 publications

(42 citation statements)

References 100 publications

(152 reference statements)

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“…Apically localized molecules play crucial roles during neural plate folding as scaffolding proteins that participate in the apical constriction of cells (Eom et al, 2011;Haigo et al, 2003;Hildebrand and Soriano, 1999;Morita et al, 2010;Nandadasa et al, 2009;Nishimura and Takeichi, 2008;Ossipova et al, 2014). For example, cadherins coordinate the cytoskeletal dynamics and cell-cell interactions necessary for tissue bending and morphogenesis (Nishimura and Takeichi, 2009;West and Harris, 2016). We discovered a molecular interaction among Folr1, C-cadherin and β-catenin.…”

Section: Discussionmentioning

confidence: 93%

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Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation

2017

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Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closure during embryogenesis. The elucidation of the mechanisms underlying folate action has been challenging. This study introduces Xenopus laevis as a model to determine the cellular and molecular mechanisms involved in folate action during neural tube formation. We show that knockdown of folate receptor 1 (Folr1; also known as FRα) impairs neural tube formation and leads to NTDs. Folr1 knockdown in neural plate cells only is necessary and sufficient to induce NTDs. Folr1-deficient neural plate cells fail to constrict, resulting in widening of the neural plate midline and defective neural tube closure. Pharmacological inhibition of folate action by methotrexate during neurulation induces NTDs by inhibiting folate interaction with its uptake systems. Our findings support a model in which the folate receptor interacts with cell adhesion molecules, thus regulating the apical cell membrane remodeling and cytoskeletal dynamics necessary for neural plate folding. Further studies in this organism could unveil novel cellular and molecular events mediated by folate and lead to new ways of preventing NTDs.

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Section: Discussionmentioning

confidence: 93%

“…Remodeling of adherens junctions between cells is crucial for tissue morphogenesis (Nishimura and Takeichi, 2009;West and Harris, 2016). C-cadherin is an important component of adherens junctions in X. laevis neural plate (Nandadasa et al, 2009).…”

Section: Molecular Knockdown Of Folate Receptor Hinders Neural Tube Cmentioning

confidence: 99%

Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation

2017

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“…Recent live-imaging studies have revealed the extent to which E-cadherin is actively turned over at adherens junctions, highlighting the extremely dynamic nature of intercellular adhesion, even in relatively stable epithelia (Kowalczyk and Nanes, 2012;West and Harris, 2016). In cases of collective epithelial cell migration, this continuous modulation of E-cadherin and other junctional components, such as catenins, is key to maintaining tissue integrity throughout cell movements.…”

Section: Adherens Junctions Cell Adhesion and Apico-basal Polaritymentioning

confidence: 99%

A common framework for EMT and collective cell migration

2016

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During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.

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“…, 2014; Zhang et al. , 2014; West and Harris, 2016). This process is inhibited by p120-catenin, which binds to the cadherin tail and masks an endocytic motif in the juxtamembrane domain (Chiasson et al.…”

Section: Introductionmentioning

confidence: 99%