Cadherin switching in oral squamous cell carcinoma: A clinicopathological study

Ali, Adnan; Ghoneim, Shams; Ahmed, Esam R.; Salam, Lubna Omar El-Farouk Abdel; Saleh, Soadad

doi:10.1016/j.jobcr.2023.05.001

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…The absence of E-cadherin in cancer leads to metastasis and diffusion ( 31 ), and activation of several EMT transcription factors, such as Twist and β-catenin ( 32 ). A significant characteristic of the EMT is the occurrence of ‘cadherin alteration’, in which there is a decrease in E-cadherin expression and an increase in N-cadherin expression ( 33 ). N-cadherin serves as a marker for active EMT, and its abnormal expression is strongly linked to multiple facets of malignant tumor advancement, including transformation, adhesion, apoptosis, angiogenesis, invasion and metastasis ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells

Liu,

Feng,

Xiang

et al. 2024

Oncol Lett

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Intrahepatic cholangiocarcinoma (ICC) is a highly invasive malignant tumor. The prognosis of patients with ICC after radical surgical resection remains poor, due to local infiltration, distant metastasis, a high recurrence rate and lack of effective treatment strategies. E26 transformation-specific sequence variant 4 (ETV4) is a pro-carcinogenic factor that is upregulated in several tumors; however, the role of ETV4 in ICC is relatively unknown.

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