Cadherin-based adhesion regulates mechanical polarization in the actin cortex through Rac1
Hao Lin,
Seyedsajad Moazzeni,
Kelly Kyker-Snowman
et al.
Abstract:Tension-adhesion interplay is a crucial mechanism in multicellular organisms that determines the tension differential among internal and external interfaces, which in turn, mediates tissue surface tension and cell sorting, morphogenesis and remodeling, and cancer progression. Cadherins are widely believed to be involved, yet key aspects of the process are neither well characterized nor quantified. This study demonstrates the critical role of N-cadherin in driving mechanical polarization throughout the actin co… Show more
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